Effects of acupoint-stimulation for the treatment of primary dysmenorrhoea compared with NSAIDs: a systematic review and meta-analysis of 19 RCTs

Xu, Yang; Zhao, Wei; Te, Li; Bu, Huaien; Zhao, Zhihui; Zhao, Ye; Song, Shilin

doi:10.1186/s12906-017-1924-8

Cited by 36 publications

(28 citation statements)

References 31 publications

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“…The pain caused by dysmenorrhea begins a few days before menstruation and persists for 48 to 72 hours. Cramping pain often reaches the thighs (Xu et al, 2017). Dysmenorrhea is one of the most common complaints of adolescents and mature women.…”

Section: Introductionmentioning

confidence: 99%

“…The causes of primary dysmenorrhea are still unclear, but one of the most accepted explanations is increased synthesis of prostaglandins, of which types E2 and F2α play a significant role in the development of ischemia and hypoxia, resulting in dysrhythmic uterine contractions and decreased blood flow (Ghafourian et al, 2015; Xu et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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An update and systematic review on the treatment of primary dysmenorrhea

Sharghi

Mansurkhani

Larky

et al. 2019

JBRA Assisted Reproduction

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Objectives:Primary dysmenorrhea is a painful uterine contraction caused by endometrial laceration. Drug therapies and complementary medicine have been used to treat dysmenorrhea. The aim of this study was to investigate and offer an updated perspective on the treatments for dysmenorrhea.Methods:The present study was conducted in accordance with the PRISMA checklist for systematic reviews and meta-analyses. The required information was collected based on searches for the following keywords: treatment, primary dysmenorrhea, medicinal plants, chemical drugs, and herbs. Searches were performed on databases Pubmed, Web of Sciences, Scopus, Iran medex, and SID by March 2018 to find literature in the English and Persian languages on this subject without a time limit.Results:This review included 17 papers, 10 of which on complementary medicine, three on drug therapies, and four on acupuncture and acupressure. The largest and smallest samples had 303 and 24 patients, respectively. Length of treatment ranged from one to six months and the measures most commonly used in the studies were the visual analogue scale and clinical efficacy. Reported complications included gastrointestinal events, nausea, vomiting, diarrhea, abdominal pain, and liver and kidney disorders.Conclusion:Medicinal plants, drugs, and acupressure seem to suppress pain by reducing the level of prostaglandins, mediating nitric oxide, increasing beta-endorphin levels, blocking the calcium channel, and enhancing circulatory flow through the uterine pathway. Further trials are required to confirm the benefits of the procedures described and ensure the absence of complications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An update and systematic review on the treatment of primary dysmenorrhea

Sharghi

Mansurkhani

Larky

et al. 2019

JBRA Assisted Reproduction

View full text Add to dashboard Cite

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“…Polyunsaturated fatty acids (PUFAs) are important for maintaining healthy cells and hormone levels. N-6 fatty acids, primarily arachidonic acid, were shown to stimulate inflammatory processes by stimulating the flux of inflammatory pro-inflammatory type-2 prostaglandins and type-4 leukotrienes [ 3 , 4 ]. The n-3 fatty acids, mostly EPA and DHA, modify cardiovascular and related diseases, but their mechanisms remain unclear [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Absorption rate of krill oil and fish oil in blood and brain of rats

Ahn

Lim²,

Ryu³

et al. 2018

Lipids Health Dis

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BackgroundKrill (Euphausia superba) is a small marine crustacean with a lipid content. The mechanism of Krill oil function is not clear yet and research reports on the absorption rate of the phospholipids of krill oil in the blood and brain are very poor.MethodsWe studied the effect of oral short-term and long-term administration of Krill oils (KOs) on bioavailability in the blood and brain of rats. For short-term testing of fish and KO bioavailability, rats were divided into four groups: normal, fish oil (FO), Krill oil 1 (KO), and Krill oil 2 (CKO). The blood and brain were collected at 2, 4, 8, 12, 24, and 48 h after oral administration (1000 mg/rat). Five hundred milligrams of FO, KO, and CKO were orally administered daily for 2 weeks for long-term administration, and then the brain and blood were collected.ResultsTwo types of KOs showed high content of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in the PL. The EPA content of CKO and KO were 41.13 and 32.49%, respectively. After short-term KO administration, KO showed a higher EPA content than CKO in the blood after 2 h. KO showed higher content of DHA than CKO even after 2 h. FO increased until 8 h, but then decreased rapidly until 12 h. Although the total unsaturated fatty acid (UFA) content of KOs was lower than the total UFS content in FO, the remaining UFS content in the brain was higher than that in FO over time. Following oral administration of FO, KO, and CKO for 1 and 2 weeks, triglycerides (TG) and PL contents in the blood for KOs were slightly higher than for FO. EPA and DHA levels in the brain were slightly higher in KOs following long-term administration, but the difference was not significant.ConclusionsBase on these findings, KOs have functional potential for the brain and vascular diseases, and can be utilized as a multi-functional material composed mainly of functional ingredients.

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“…A substantial body of evidence demonstrates that acupuncture is effective for chronic pain. 15 – 35 Consequently, a number of health policy and practice-oriented guidelines have been issued that support the use of acupuncture for chronic pain. For example, the American College of Physicians Clinical Practice Guideline recommends acupuncture for acute, subacute, and chronic low back pain (cLBP).…”

Section: Introductionmentioning

confidence: 99%

Acupuncture for Chronic Pain in the Vermont Medicaid Population: A Prospective, Pragmatic Intervention Trial

Davis¹,

Badger²,

Valentine

et al. 2018

Glob Adv Health Med

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IntroductionIn response to the opioid crisis, the 2016 Vermont legislature commissioned a study to assess acupuncture for patients with chronic pain in the Vermont Medicaid population.ObjectiveTo assess the feasibility, acceptability, and effectiveness of acupuncture provided by licensed acupuncturists for Vermont Medicaid patients with chronic pain.MethodsA total of 156 Medicaid patients with chronic pain were offered up to 12 acupuncture treatments within a 60-day period at the offices of 28 Vermont licensed acupuncturists. PROMIS® questionnaires were administered prior to and at the end of the treatment period to assess changes in pain intensity, pain interference, physical function, fatigue, anxiety, depression, sleep disturbance, and social isolation. Questionnaires also captured patients’ overall impressions of treatments as well as self-reported changes in medication use and work function.ResultsOne hundred eleven women (71%) and 45 men (29%) with a wide range of pain complaints received a mean of 8.2 treatments during the intervention period. Measurements captured prior to and at the end of the treatment period showed significant improvements in group mean pain intensity, pain interference, physical function, fatigue, anxiety, depression, sleep disturbance, and social isolation as assessed by Patient-Reported Outcomes Measurement Information System (PROMIS) measures (paired t tests, P < .01). Fifty-seven percent of patients using analgesic (nonopioid) medication reported reductions in use. Thirty-two percent of patients using opioid medication reported reductions in use of opioid medication following the intervention. Seventy-four percent of employed patients reported improved capacity to work. Ninety-six percent of patients said that they would recommend acupuncture to others with chronic pain, and 91% reported qualitative improvements, including physical (31%), functional/behavioral (29%), and psycho-emotional (24%) improvements.ConclusionsOur findings demonstrate that acupuncture treatment for chronic pain is feasible and well received by patients in the Vermont Medicaid population. Receiving care from Licensed Acupuncturists was associated with significant improvements in physical, functional, psycho-emotional, and occupational outcomes compared with before receiving acupuncture treatments.

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Effects of acupoint-stimulation for the treatment of primary dysmenorrhoea compared with NSAIDs: a systematic review and meta-analysis of 19 RCTs

Cited by 36 publications

References 31 publications

An update and systematic review on the treatment of primary dysmenorrhea

An update and systematic review on the treatment of primary dysmenorrhea

Absorption rate of krill oil and fish oil in blood and brain of rats

Acupuncture for Chronic Pain in the Vermont Medicaid Population: A Prospective, Pragmatic Intervention Trial

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