Effects of active hexose correlated compound on frequency of CD4+ and CD8+ T cells producing interferon-γ and/or tumor necrosis factor–α in healthy adults

Yin, Zhinan; Fujii, H.; Walshe, Thomas M.

doi:10.1016/j.humimm.2010.08.006

Cited by 33 publications

(30 citation statements)

References 14 publications

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“…Several studies in humans have shown the potential beneficial effects of AHCC on the immune system but very little is known about the effects of this compound on resistance to chlamydia genital infection. Our results are consistent with previous studies that show AHCC enhances the function of the immune system of humans [14–16,23–25,44] and rodents [19–21,25]. The enhancement of peritoneal macrophages by AHCC may result in activation of several components of innate immunity, including complement and acute phase proteins [45], inducing the synthesis and release of proinflammatory cytokines such as TNF-α, IL-1, and IL-6.…”

Section: Discussionsupporting

confidence: 94%

Active Hexose Correlated Compound Activates Immune Function to Decrease Chlamydia trachomatis Shedding in a Murine Stress Model

Belay

Woart

2015

J Nutri Med Diet Care

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A cold-induced stress mouse model for investigating chlamydia genital infection and immune response analysis was established in our laboratory. Previous results showed that cold-induced stress results in suppression of the immune response and increased intensity of chlamydia genital infection in the mouse model. The purpose of the present study was to evaluate the potential therapeutic value of active hexose correlated compound (AHCC) against chlamydia genital infection in mice. AHCC is an extract of mushroom commonly used as a dietary supplement is known to boost the immune system. Mice were infected intravaginally with Chlamydia trachomatis after a 24-day cold-stress application. Oral administration of AHCC to stressed or non-stressed mice was carried out seven days before infection and during the course of infection along with cervicovaginal swabbing. Cytokine production by peritoneal and splenic T cells isolated from AHCC-fed stressed mice and non-stressed mice was measured ELISA. Splenic T cells from both animal groups were co-cultured with mouse monocyte J774.2 cell line or cultured by addition of supernatants of AHCC-treated J774.2 cell line for 24 hours. Infection studies showed that AHCC-feeding compared to phosphate buffered saline (PBS)-feeding to stressed mice resulted in reduced Chlamydia trachomatis shedding from the genital tract. Levels of tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6) were significantly increased in stressed mice receiving AHCC compared to stressed mice receiving PBS. Production of interferon gamma (IFN-γ) and interleukin 2 (IL-2) in the AHCC group was significantly high compared to production in PBS-fed group. Splenic T cells from stressed and non-stressed cultured with supernatants of AHCC-treated J774.2 cell line resulted in significantly increased TNF-α or IFN-γ production. Results obtained in this study show that AHCC improves the function of immune cells as indicated by the restoration of levels of cytokines production that were suppressed under cold induced-stress conditions. This is the first report showing that oral administration of AHCC enhances the function of the immune system, which could result in increased resistance of the host to chlamydia genital infection.This is an open

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Section: Discussionsupporting

confidence: 94%

Active Hexose Correlated Compound Activates Immune Function to Decrease Chlamydia trachomatis Shedding in a Murine Stress Model

Belay

Woart

2015

J Nutri Med Diet Care

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“…Glucocorticoids inhibit IL-12 (a cytokine that causes T H 1 cells to shift to T H 2 cells), increase delayed-type hypersensitivity, and regulate the innate immune response to bacterial and viral infections. 3,6Y13,29 They suppress maturation, differentiation, and proliferation of all immune cells. Proinflammatory agents, such as bacterial lipopolysaccharide, stimulate the HPA axis to synthesize and release glucocorticoids.…”

Section: Discussionmentioning

confidence: 99%

“…AHCC improves CD4+ and CD8+ T-cell immune responses in healthy elderly persons. 3 It prolongs survival and improves the prognosis of patients with liver cancer. 4,5 AHCC supplementation has been shown to improve immune response to influenza infection, 6 West Nile encephalitis, 7 various infections with Klebsiella pneumoniae, Candida albicans, Pseudomonas aeruginosa, methicillinresistant Staphylococcus aureus, 8 and surgical wound infections in rodent models.…”

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confidence: 99%

A natural immune modulator attenuates stress hormone and catecholamine concentrations in polymicrobial peritonitis

Love

Barnett

Holbrook

et al. 2013

Journal of Trauma and Acute Care Surgery

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“…Active hexose correlated-compound (AHCC) is an extract obtained from L. edodes of Basidiomycetes family that is commercially available in Japan as a supplement for cancer patients who are undergoing chemotherapy. AHCC has been proven to stimulate cytokines (IL-2, IL-6, IL-12 and TNF-a) [7] and boost the immune system as an immunomodulator [8][9][10]. In addition, supplementation of AHCC showed various positive effects against cancer, such as decreased tumor formation [11] and increased immune response [8,10].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effect of Active Hexose-Correlated Compound (AHCC) combined with CpG-ODN (oligodeoxynucleotide) in B16 melanoma murine model

Ignacio

Kim

et al. 2015

Cytokine

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Effects of active hexose correlated compound on frequency of CD4+ and CD8+ T cells producing interferon-γ and/or tumor necrosis factor–α in healthy adults

Cited by 33 publications

References 14 publications

Active Hexose Correlated Compound Activates Immune Function to Decrease Chlamydia trachomatis Shedding in a Murine Stress Model

Active Hexose Correlated Compound Activates Immune Function to Decrease Chlamydia trachomatis Shedding in a Murine Stress Model

A natural immune modulator attenuates stress hormone and catecholamine concentrations in polymicrobial peritonitis

Therapeutic effect of Active Hexose-Correlated Compound (AHCC) combined with CpG-ODN (oligodeoxynucleotide) in B16 melanoma murine model

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