Effects of acrylamide graded doses on metallothioneins I and II induction and DNA fragmentation: Bochemical and histomorphological changes in the liver of adult rats

Ghorbel, Imen; Elwej, Awatef; Chaabene, Mariem; Boudawara, Ons; Marrakchi, Rim; Jamoussi, Kamel; Boudawara, T.; Zeghal, Najiba

doi:10.1177/0748233717696613

Cited by 25 publications

(19 citation statements)

References 48 publications

(54 reference statements)

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“…Acrylamide group (AA): 40 mg/kg/d acrylamide (A8887; Merck, Darmstadt, Germany) was dissolved in physiological serum and orally administered by gavage for 21 days. [ 14 ]…”

Section: Methodsmentioning

confidence: 99%

Protective effect of carnosic acid on acrylamide‐induced liver toxicity in rats: Mechanistic approach over Nrf2‐Keap1 pathway

Dönmez

Kaçar

Bağcı

et al. 2020

J Biochem & Molecular Tox

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Acrylamide is a food contaminant with a range of toxic effects. Carnosic acid (C20H28O4) is a phenolic compound found in plants and has many beneficial effects. In this study, we aimed at investigating the effect of carnosic acid on acrylamide‐induced liver damage. Rats (n = 7) were allotted to control, carnosic acid, acrylamide, acrylamide + carnosic acid groups. Animals were euthanized. Their blood was taken for biochemical analysis, and liver tissue was excised for morphological, immunohistochemical, and immunoblotting analyses. As a result, acrylamide reduced bodyweight, liver weight, catalase, and total antioxidant capacity levels but increased alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, malondialdehyde, total oxidant status, oxidative stress index levels, Nrf2, and Keap1 protein levels. In addition, acrylamide disrupted liver histology leading to vascular congestion, cellular infiltration, necrotic cells, and so forth. Carnosic acid cotreatment ameliorated the altered biochemical parameters, liver histology, Nrf2, and Keap1 enzyme levels. In conclusion, carnosic acid has the potential to be used as a protective agent against acrylamide‐induced liver damage.

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“…Acrylamide group (AA): 40 mg/kg/d acrylamide (A8887; Merck, Darmstadt, Germany) was dissolved in physiological serum and orally administered by gavage for 21 days. [ 14 ]…”

Section: Methodsmentioning

confidence: 99%

Protective effect of carnosic acid on acrylamide‐induced liver toxicity in rats: Mechanistic approach over Nrf2‐Keap1 pathway

Dönmez

Kaçar

Bağcı

et al. 2020

J Biochem & Molecular Tox

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“…Additionally, investigators found that AOPPs were significantly increased in the plasma and the liver of methylglyoxal treated rats, and the elevated AOPPs could be significantly reduced by treated with resveratrol and carnosine . In addition to the above‐mentioned studies, an increase in liver AOPPs was also noted in methylthiophanate‐, acrylamide‐ and difenoconazole‐treated rats . Although many studies have referred to the profound effects of AOPPs on the progression of diverse liver damages, there have been few studies investigating the potential mechanisms.…”

Section: Data Sourcesmentioning

confidence: 99%

Advanced oxidation protein products play critical roles in liver diseases

Zhao

Zhang

Ouyang

et al. 2019

Eur J Clin Investigation

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There is a complex oxidant and antioxidant system that maintains the redox homoeostasis in the liver. While suffering from exogenous or endogenous risk factors, the balance between oxidants and antioxidants is disturbed and excessive reactive oxygen species are generated, resulting in oxidative stress. Oxidative stress is prevalent in various liver diseases and is thought to be involved in their pathophysiology. Advanced oxidation protein products are generated under conditions of oxidative damage and are newly described protein markers of oxidative stress. Previous studies have underscored the universal pathogenic roles of oxidation protein products in various diseases. However, investigations into how these products participate in the development of liver diseases have been superficial and insufficient. In this review, we highlight the current understanding of the roles of advanced oxidation protein products in liver disease pathogenesis and the underlying mechanisms. Moreover, we summarize the current studies on advanced oxidation protein products in infectious and noninfectious, acute and chronic liver diseases. Different strategies for targeting these advanced oxidation protein products and future perspectives, which may pave the way for developing new therapeutic strategies, will also be discussed here.

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“…Negative control (sham) received distilled water II) Positive control received AA III) AA-intoxicated rats treated with 2.5 ml/kg lemon juice IV) AA-intoxicated rats treated with 5.0 ml/kg lemon juice V) AA-intoxicated rats treated with 7.5 ml/kg lemon juice Oxidative stress in rats was induced orally by gavage AA (35 mg/kg) daily (800830, Merck, Germany) for 2 week (El-Mehi, El-Sherif, 2015; Ghorbel et al, 2017). Lemon was supplied from a local market collecting in Shush, a city located in Khuzestan province, Iran in December 2017.…”

Section: Experimental Protocolmentioning

confidence: 99%

Protective effect of citrus lemon on inflammation and adipokine levels in acrylamide-induced oxidative stress in rats

Haidari

Mohammadshahi

Zarei

et al. 2019

Braz. J. Pharm. Sci.

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The high exposure to acrylamide (AA) due to smoking and increased consumption of processed and fast foods in recent years, has become one of the health threatening problems. This study examined the effect of lemon juice on inflammation and adipokines in acrylamide-induced oxidative stress in rats. Forty animals were divided into five groups. Toxicity was induced by AA (35mg/kg) for two weeks in all groups except normal control group. After that, lemon juice in three doses was administrated to treatment groups for 4 weeks. Serum levels of adipokines and inflammatory parameters and both serum and liver levels of oxidative stress parameters were measured. The results showed groups were received AA had significant higher levels of malondialdehyde, tumor necrosis factor alpha, leptin and C-reactive protein and lower levels of total antioxidant capacity compared to the negative control group. Lemon juice in all three doses significantly improved serum levels of TAC, MDA, TNFα and hs-CRP in treated groups. Also, 7.5 ml/kg lemon juice significantly decreased leptin levels. However, lemon juice had no significant effect on adiponectin levels. This study suggests lemon juice as a potential dietary alternative could attenuate leptin levels and manage oxidative and inflammatory damages in acrylamide-induced toxicity in rats.

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Effects of acrylamide graded doses on metallothioneins I and II induction and DNA fragmentation: Bochemical and histomorphological changes in the liver of adult rats

Cited by 25 publications

References 48 publications

Protective effect of carnosic acid on acrylamide‐induced liver toxicity in rats: Mechanistic approach over Nrf2‐Keap1 pathway

Protective effect of carnosic acid on acrylamide‐induced liver toxicity in rats: Mechanistic approach over Nrf2‐Keap1 pathway

Advanced oxidation protein products play critical roles in liver diseases

Protective effect of citrus lemon on inflammation and adipokine levels in acrylamide-induced oxidative stress in rats

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