Effects of Acetyl Salicylic Acid Therapy on an Experimental Thrombosis Induced by Laser Beam

Aguejouf, Omar; Malfatti, Emmanuelle; Belon, Philippe; Doutremépuich, Christian

doi:10.1016/s0049-3848(00)00270-x

Cited by 8 publications

(7 citation statements)

References 25 publications

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“…The first experimental model showed paradoxical or secondary thromboembolism after the administration of substantial [6][7][8][9][10][11][12][13][14][15] or ultra low 16,17 doses of antithrombotic agents (rebound effect). The second model showed the effect of substantial 18 or ultra low [19][20][21][22][23] doses of aspirin in prophylaxis or reduction of hemorrhagic risks (reducing the bleeding time or the antithrombotic effect), neutralising the side effect of aspirin previously administration in high doses (identity principle or curative rebound effect).…”

Section: Discussionmentioning

confidence: 99%

“…Experimental studies, in vitro and in vivo, show that after the interruption or discontinuation of ASA or other drugs for prophylaxis of thromboembolism, the organism reacts by a secondary action or vital reaction that stimulates the COX-1 production and the blood platelet activity to values much higher than baseline, increasing the development of thrombus and the probability of a embolic event [acute myocardial infarction (AMI), cerebral vascular accident (CVA), etc] in susceptible individuals, both in substantial, [6][7][8][9][10][11][12][13][14][15] and infinitesimal doses. 16,17 Other experiments showed the effect of substantial 18 or ultra low [19][20][21][22][23] doses of aspirin in prophylaxis or reduction of haemorrhagic risks (reducing the bleeding time or the anti-thrombotic effect), neutralising the side effect of previously administered aspirin.…”

Section: Similitude and Aspirinmentioning

confidence: 99%

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Evidence of the principle of similitude in modern fatal iatrogenic events

Teixeira

2006

Homeopathy

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Samuel Hahnemann attributed fundamental importance to the principle of similitude, promoting it to a 'natural law'. Observing that enantiopathic or allopathic treatment produced enduring aggravation of the disease symptoms after a brief and transitory initial relief, he systematised homeopathic treatment, prescribing substances that provoke similar symptoms in healthy individual. Based on clinical and experimental observations, he anticipated the concept of homeostasis, dividing the effects of substances into: primary action of the medicine followed by secondary action or reaction of the organism. This reaction, known as the rebound effect or paradoxical action by modern pharmacology, used to awake the curative response of the body when the principle of similitude is applied, is responsible for several iatrogenic diseases when used on the basis of the principle of contraries. This study discusses the role of this paradoxical reaction of the organism in the fatal side effects of four important drugs, used according to the model of enantiopathic treatment of the symptoms. I present evidence relating to acetylsalicylic acid, rofecoxib, antidepressants and long-acting bronchodilators. The consequences of the allopathic treatment could be decreased if health professionals valued homeostasis, minimising the rebound effect of the organism by gradual suspension of palliative drugs.

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Section: Discussionmentioning

confidence: 99%

Section: Similitude and Aspirinmentioning

confidence: 99%

Evidence of the principle of similitude in modern fatal iatrogenic events

Teixeira

2006

Homeopathy

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“…Subsequently, this group 53 also demonstrated a potent antithromboembolic effect of potentized acetyl salicyclic acid in similarly induced experimental thrombosis. Researchers in Germany have observed an inhibitory effect of ultradiluted dichlorophenol on the bacterium Vibrio fischeri.…”

Section: In Vivo Laboratory Experiments and A Few Other Hypotheses Onmentioning

confidence: 95%

Laboratory Research in Homeopathy: Pro

Khuda‐Bukhsh

2006

Integr Cancer Ther

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Homeopathy is a holistic method of treatment that uses ultralow doses of highly diluted natural substances originating from plants, minerals, or animals and is based on the principle of "like cures like." Despite being occasionally challenged for its scientific validity and mechanism of action, homeopathy continues to enjoy the confidence of millions of patients around the world who opt for this mode of treatment. Contrary to skeptics' views, research on homeopathy using modern tools mostly tends to support its efficacy and advocates new ideas toward understanding its mechanism of action. As part of a Point-Counterpoint feature, this review and its companion piece in this issue by Moffett et al (Integr Cancer Ther. 2006;5:333-342) are composed of a thesis section, a response section in reaction to the companion thesis, and a rebuttal section to address issues raised in the companion response.

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“…We previously demonstrated a prothrombotic activity of aspirin 7 days after a single-dose administration (100 mg/kg) as evidenced by an increase in the number of emboli and the duration of embolization [11] . We suggested that this effect may explain thromboembolic complications observed in patients after they had stopped aspirin therapy.…”

Section: Discussionmentioning

confidence: 97%

“…We have previously demonstrated that aspirin could exhibit late thrombotic properties 8-10 days after administration. This phenomenon might explain the thromboembolic complications observed in some patients [10,11] . We have also shown that aspirin at ultra low dose (ULDA) has prothrombotic activity [12] .…”

Section: Introductionmentioning

confidence: 90%

Reverse Effect of Aspirin: Is the Prothrombotic Effect after Aspirin Discontinuation Mediated by Cyclooxygenase 2 Inhibition?

Doutremépuich

Aguejouf

Eizayaga

et al. 2007

Pathophysiol Haemos Thromb

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Background: While aspirin is the drug most often used to prevent cardiovascular complications, its discontinuation induces an increased risk of acute coronary syndrome and ischemic stroke in some patients. Objectives: We hypothesized that infinitesimal concentrations of aspirin could persist in plasma after its discontinuation, thereby inducing a prothrombotic effect that could be due to a modification in the mechanism of action of aspirin via the cyclooxygenase 1 (COX-1) and COX-2 pathways. Methods and Results: We studied the effects of ultra-low-dose aspirin (ULDA) as well as those of sc-560 and ns-398, specific COX-1 and COX-2 inhibitors, on induced hemorrhagic time and in a model of laser-induced thrombosis in rats. In the laser-induced thrombosis model, ULDA treatment increased the number of emboli and the duration of embolization, thereby confirming its prothrombotic effect described in previous publications. This effect was also observed in rats pretreated with sc-560 but not in those pretreated with ns-398. Conclusions: We demonstrated that ULDA induced a prothrombotic effect in the rats studied. This strongly suggests that a very small amount of aspirin could remain in the patient’s blood after aspirin therapy, leading to cardiovascular complications. This effect may be mediated by the COX-2 pathway.

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Effects of Acetyl Salicylic Acid Therapy on an Experimental Thrombosis Induced by Laser Beam

Cited by 8 publications

References 25 publications

Evidence of the principle of similitude in modern fatal iatrogenic events

Evidence of the principle of similitude in modern fatal iatrogenic events

Laboratory Research in Homeopathy: Pro

Reverse Effect of Aspirin: Is the Prothrombotic Effect after Aspirin Discontinuation Mediated by Cyclooxygenase 2 Inhibition?

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