Effects of Acetaminophen as a Toxic Drug on the Liver Function in Poultry

Abstract

Context: The most prevalent diseases in country poultry industry that will infect broiler chickens epidemic; be disrupts the liver function. The liver is an important diagnostic organ in broilers is raised and on the other hand, Because of speed up the metabolism in broiler chickens in order to increase production and efficiency, Hepatic Cytochrome p-450 system, acetaminophen is metabolizes to the one potentially toxic metabolite called N-acetyl-Parabanzoqin-imin (NAPQI) By Conjugation with glutathione, mercaptorick acid be converted that the acid is soluble in water and is excreted through the kidneys and is largely harmless. But in high doses, with high production of toxic metabolites, Glutathione reserves available the finished and therefore, Context, provided for necrosis, and the continuation of this process Can be seen Laboratory evidence of liver cell necrosis (Increased levels of serum transaminases) and liver dysfunction. The liver is an important center involved in the metabolism, and the important medium of the gastrointestinal tract and the blood has a special importance and any Liver damage in broiler chickens in the first step, on the nutrition and consequently will affect on the efficiency of chickens.Methods: 40 chicks were randomly were divided to two treatments and 20 replications for each treatment. Treatments included: control group, and poisoned group. And at the end of the period of investigation, enzymes that the liver function indicators (AST, ALT, ALP) were determined and examined.Acetaminophen medication manufactured by the pharmaceutical Aria (Tehran, Iran) with a dose 650 mg per kg of live weight of chickens were used for 7 days. Results:With a high level of assurance can be said that the use of acetaminophen drug at a dose was used thereby increasing is All three indexes liver enzymes (AST, ALT and ALP), because the differences mentioned significant at less than 0/01. Conclusion:Drug acetaminophen at doses of 650 mg per kg body weight of broiler chickens for one week, it can establish liver toxicity and in research as an inducer drug of poisoning In order to research on other diseases that impair the function of the liver Such as cites disease, can be used.