Effects of açai on the inflammatory response of NLRP3 in experimental diabetes mellitus

Lima, Deyse Y.; Serralha, Robson; Bertolini, A.; Ferres, Lucas; Barroso, Rômulo; Mouro, Margaret Gori; Punaro, Giovana Rita; Higa, Elisa Mieko Suemitsu

doi:10.1016/j.freeradbiomed.2021.12.194

Cited by 1 publication

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“…Not only would NLRP3 activate and initiate the inflammatory response, but also directly damage tissue cells, causing metabolic disorders and lipid deposition, etc. [ 35 ], which in turn further activates NLRP3. The activated NLRP3 recruits to pro-caspase-1, leading to the activation of caspase-1 [ 36 ], then the activated caspase-1 processes pro-IL-1 β and pro-IL-18 for cleavage and processing, forming mature IL-1 β and IL-18 and releasing them extracellularly [ 37 , 38 ], exacerbating the inflammatory response [ 39 – 42 ], thus promoting the development and progression of NASH.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of baicalin magnesium on non-alcoholic steatohepatitis rats are based on inhibiting NLRP3/Caspase-1/IL-1β signaling pathway

Guan

Shi-yuan

Liu

et al. 2023

BMC Complement Med Ther

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Baicalin magnesium is a water-soluble compound isolated from the aqueous solution by Scutellaria baicalensis Georgi. Preliminary experiments have demonstrated that baicalin magnesium can exert protective effects against acute liver injury in rats induced by carbon tetrachloride or lipopolysaccharide combined with d-galactose by regulating lipid peroxidation and oxidative stress. The aim of this study was to investigate the protective effect of baicalin magnesium on non-alcoholic steatohepatitis (NASH) in rats and to elucidate the underlying mechanisms. NASH was induced through a high-fat diet (HFD) for 8 weeks, and Sprague-Dawley rats were intravenously injected with baicalin magnesium, baicalin, and magnesium sulfate for 2 weeks, respectively. Serum was obtained for biochemical analyses and the determination of oxidative stress indicators. Liver tissues were collected for use in liver index assessment, histopathological examination, inflammatory factor analysis, and protein and gene expression analysis. The results revealed that baicalin magnesium markedly improved HFD-induced lipid deposition, inflammatory response, oxidative stress, and histopathological impairments. And baicalin magnesium may exert a protective effect on NASH rats by inhibiting the NLR family pyrin domain involving the 3 (NLRP3)/caspase-1/interleukin (IL)-1β inflammatory pathway. Additionally, the effect of baicalin magnesium was remarkably superior to that of equimolar baicalin and magnesium sulfate in regard to ameliorating NASH symptoms. In conclusion, the findings suggested that baicalin magnesium may represent a potential drug for the treatment of NASH.

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