Effects of a weight-reduction program with orlistat on serum leptin levels in obese women: A 12-week, randomized, placebo-controlled study

Abstract

Background: Leptin, which has been identified as an antiobesity hormone, regulates body weight by controlling food intake and energy expenditure via the hypothalamic-pituitary-gonadal axis. It appears that leptin may be an important factor in obesity management. Orlistat, a pancreatic lipase inhibitor, could reduce fat absorption and promote weight loss due to leptin metabolism.Objective: The purpose of this study was to investigate the effects of orlistat therapy on serum leptin levels.Methods: Obese women (body mass index [BMI], 30 kg/m 2 ) aged 18 to 50 years were randomly assigned to receive 12 weeks of oral treatment with diet-orlistat (120 mg TID) (DO group) or diet-placebo (DP group). During the treatment period, patients were asked to eat a balanced diet of ∼1200 to 1600 kcal/d. Body composition was determined by bioelectrical impedance. Serum leptin levels were measured using radioimmunoassay at baseline and at study end.Results ) received placebo. Compared with baseline, mean percentages of loss of body weight and fat mass after 12 weeks of treatment were significant in the DO group (9.1% and 14.8%, respectively; both P = 0.001) and in the DP group (9.5% and 17.6%; both P = 0.005). The between-group differences were not statistically significant. Mean (SE) serum leptin levels also decreased significantly after treatment in the DO group (16.2 [1.2] vs 9.0 [1.0] ng/mL; P = 0.001) and in the DP group (19.3 [2.1] vs 9.7 [1.4] ng/mL; P = 0.005). The between-group difference was not statistically significant.Conclusions: In this study of obese women, orlistat treatment was associated with a similar decrease in body weight, fat mass, and serum leptin levels Accepted for publication January 20, 2004. Reproduction in whole or part is not permitted.0011-393X/04/$19.00 as placebo over a 12-week period. In this regard, short-term orlistat therapy may not provide an additional effect on serum leptin levels, and reduction in leptin levels were closely related to the decrease in fat mass. (Curr Ther Res Clin Exp. C U R R E N T T H E R A P E U T I C R E S E A R C H ாV

Improvement of plasma adiponectin, leptin and C‐reactive protein concentrations by orlistat: a systematic review and meta‐analysis

“…Of these 534 publications, 17 were selected for full-text assessment. After careful assessment, 12 articles met the inclusion criteria and were selected for meta-analysis [17,[26][27][28][29][30][31][32][33][34][35][36]. Reasons for rejecting the other five articles were as follows: three were uncontrolled studies, one study was not written in English, and one study [37] reported data for the overall population without providing separate numerical values for leptin levels in the orlistat and placebo groups.…”

“…The maximum licensed dose of orlistat (360 mg/day) was used in the included trials, with the exception of one study where the dose administered was not revealed [26]. Duration of studies ranged from 3 months [34][35][36] [17,[28][29][30]] to 36 months [32,33]. All trials were designed as parallel-group studies [17,[26][27][28][29][30][31][32][33][34][35][36], all were double arm parallel-group studies [17,[26][27][28][29][30][31][32][33][34]36], and one was a triple arm parallel-group study [35].…”

Efecto del tratamiento de dos días con orlistat sobre los niveles de leptina plasmática en pacientes obesas sin pérdida de peso

“…Hsieh et al (25), after one year of treatment in Asian obese patients, observed that over the same range of BMI, body fat% and waist circumference loss, the orlistat treatment group experienced more significant changes in plasma levels of leptin than the control group. On the other hand, Ozcelik et al (26) showed, after 12 weeks, a similar decrease in plasma leptin in 14 patients who received orlistat and 10 patients that received placebo.…”

Benzothiazole Thioflavin T improves obesity-related symptoms in mice

“…The significant effect of ThT on leptin is specially of interest, with regard to the importance of this adipokine in weight regulation (27). Recently proposed antiobesity compounds that act on accumulation of visceral fat have also been observed to influence leptin levels (28), (29), (30).…”