Effects of a Weight Loss Program on Metabolic Syndrome, Eating Disorders and Psychological Outcomes: Mediation by Endocannabinoids

Pataky, Zoltan; Carrard, Isabelle; Thomas, Aurélien; Carpentier, Anne; Bobbioni-Harsch, Elisabetta; Golay, Alain

doi:10.1159/000487890

Cited by 16 publications

(9 citation statements)

References 41 publications

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“…While the animal data are not in agreement with the outcome of the current study, the ECS in animals may not necessarily be representative of the human ECS. PEA, in contrast, has been positively associated with total cholesterol and LDL cholesterol concentrations [47]. Interestingly, associations of PEA with HDL cholesterol were also positive in the current study whilst inverse associations were demonstrated previously [14].…”

Section: Discussionsupporting

confidence: 44%

Effects of a High-Protein Diet on Cardiometabolic Health, Vascular Function, and Endocannabinoids—A PREVIEW Study

et al. 2020

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An unfavorable lipid profile and being overweight are known mediators in the development of cardiovascular disease (CVD) risk. The effect of diet, particularly high in protein, remains under discussion. Therefore, this study examines the effects of a high-protein (HP) diet on cardiometabolic health and vascular function (i.e., endothelial function, arterial stiffness, and retinal microvascular structure), and the possible association with plasma endocannabinoids and endocannabinoid-related compounds in overweight participants. Thirty-eight participants (64.5 ± 5.9 (mean ± SD) years; body mass index (BMI) 28.9 ± 4.0 kg/m2) were measured for 48 h in a respiration chamber after body-weight maintenance for approximately 34 months following weight reduction. Diets with either a HP (n = 20) or moderate protein (MP; n = 18) content (25%/45%/30% vs. 15%/55%/30% protein/carbohydrate/fat) were provided in energy balance. Validated markers for cardiometabolic health (i.e., office blood pressure (BP) and serum lipoprotein concentrations) and vascular function (i.e., brachial artery flow-mediated vasodilation, pulse wave analysis and velocity, and retinal microvascular calibers) were measured before and after those 48 h. Additionally, 24 h ambulatory BP, plasma anandamide (AEA), 2-arachidonoylglycerol (2-AG), oleoylethanolamide (OEA), palmitoylethanolamide (PEA), and pregnenolone (PREG) were analyzed throughout the day. Office and ambulatory BP, serum lipoprotein concentrations, and vascular function markers were not different between the groups. Only heart rate (HR) was higher in the HP group. HR was positively associated with OEA, while OEA and PEA were also positively associated with total cholesterol (TC) and low-density lipoprotein (LDL) cholesterol concentrations. Vascular function markers were not associated with endocannabinoids (or endocannabinoid-related substances). In conclusion, the HP diet did not affect cardiometabolic health and vascular function in overweight participants after completing a weight-loss intervention. Furthermore, our data indicate a possible association between OEA and PEA with TC and LDL cholesterol.

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Section: Discussionsupporting

confidence: 44%

Effects of a High-Protein Diet on Cardiometabolic Health, Vascular Function, and Endocannabinoids—A PREVIEW Study

et al. 2020

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“…They suggest a dual focus for weight loss interventions including weight loss strategies (lifestyle approaches, pharmacotherapy or surgery) and psychological well-being (evaluation and treatment of disordered eating symptoms) [ 48 ]. Pataky et al (2018) [ 49 ] showed that psychological parameters (e.g., eating, shape and weight concerns, disinhibition and self-esteem) can be improved in groups of participants that lost weight as well in groups that remained weight stable after 12 months of a multidisciplinary and lifestyle weight loss program. They hypothesized that the stabilization of weight can help the prevention of further weight gain during one year [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

“…Pataky et al (2018) [ 49 ] showed that psychological parameters (e.g., eating, shape and weight concerns, disinhibition and self-esteem) can be improved in groups of participants that lost weight as well in groups that remained weight stable after 12 months of a multidisciplinary and lifestyle weight loss program. They hypothesized that the stabilization of weight can help the prevention of further weight gain during one year [ 49 ]. It may be that weight stability can be as important as weight loss in some lifestyle respects for individuals with a high BMI receiving treatment.…”

Section: Discussionmentioning

confidence: 99%

Physical and mental health outcomes of an integrated cognitive behavioural and weight management therapy for people with an eating disorder characterized by binge eating and a high body mass index: a randomized controlled trial

et al. 2022

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Background Bulimia nervosa (BN) and binge eating disorder (BED) are eating disorders (EDs) characterized by recurrent binge eating. They are associated with medical complications, impaired adaptive function and often a high BMI, for which a multidisciplinary treatment approach may be needed. This study explored the efficacy of a novel intervention integrating Cognitive Behavioural Therapy- Enhanced (CBT-E) and weight management for people with recurrent binge eating episodes and high BMI with respect to physical, psychopathological and quality of life outcomes. Methods Ninety-eight adults diagnosed with BN, BED, or Other Specified/Unspecified Feeding or Eating Disorder (OSFED/UFED) and BMI ≥ 27 to <40 kg/m2 were randomized to a multidisciplinary approach, the Healthy APproach to weIght management and Food in Eating Disorders (HAPIFED) or to CBT-E. Metabolic parameters, health-related quality of life, general psychological and ED symptoms and ED diagnostic status outcomes are reported. Data were analyzed with mixed effects models adopting multiple imputed datasets where data were missing. Results Both HAPIFED and CBT-E showed statistical significance for the time effect, with reduction in stress (p < 0.001), improvement in mental health-related quality of life (p = 0.032), reduction in binge eating severity (p < 0.001), and also in global ED symptoms scores (p < 0.001), with the significant changes found at end of treatment and sustained at 12-month follow-up. However, no statistical significance was found for differences between the interventions in any of the outcomes measured. Despite a high BMI, most participants (> 75%) had blood test results for glucose, insulin, triglycerides and cholesterol within the normal range, and 52% were within the normal range for the physical component of quality of life at baseline with no change during the trial period. Conclusion Integrating weight and ED management resulted in comparable outcomes to ED therapy alone. Although adding weight management to an ED intervention had no adverse effects on psychological outcomes, it also had no beneficial effect on metabolic outcomes. Therefore, more intense weight management strategies may be required where indicated to improve metabolic outcomes. Safety will need to be concurrently investigated. Trial registration US National Institutes of Health clinical trial registration number NCT02464345, date of registration 08/06/2015. Changes to the present paper from the published protocol paper (Trials 18:578, 2015) and as reported in the Trial registration (clinicaltrials.gov) are reported in Supplementary File 1.

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“…Sendo assim, um programa multidisciplinar que envolva a atuação do psicólogo no processo de avaliação, comprometimento e desenvolvimento das habilidades emocionais, traz benefícios a saúde, melhoria na qualidade de vida e, consequentemente, a perda de peso. (Pataky et al, 2018) As avaliações psicológicas contribuem, não só para coletar dados e informações acerca das demandas e queixas dos Outro fator determinante encontrado dentro dos critérios estabelecidos é a pouca produção Brasileira de avaliação referente a essa temática, em comparação com as contribuições dos estudos internacionais. A diferença é expressiva, visto que Research, Society andDevelopment, v. 11, n. 1, e21111125038, 2022 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v11i1.25038 1 (um) estudo brasileiro foi selecionado, frente a 13 estudos internacionais.…”

Section: Discussionunclassified

Instrumentos utilizados na avaliação psicológica no tratamento da obesidade: revisão integrativa

Silva

Santo

Ribeiro

et al. 2022

RSD

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Os instrumentos utilizados na avaliação psicológica no tratamento clínico ou cirúrgico da obesidade tem grande relevância no resultado e processo da avaliação. Identificar personalidade, ansiedade, depressão e compulsão alimentar é fundamental, pois são fatores que podem afetar diretamente na manutenção do peso e adesão ao tratamento. O objetivo desta pesquisa foi analisar a literatura científica sobre instrumentos utilizados na avaliação psicológica da pessoa obesa. Trata-se de uma revisão integrativa realizada nas bases de dados: BVS, Medical Subject Headings (MeSH), da National Library, com os seguintes descritores controlados: "psychometrics”, "psychological test", “Psychological Assessment”, "psychologist", "obesity", "overweight" e o descritor não controlado "psychological assessment” e os operadores booleanos “OR” e “AND”. Ao final das buscas, 14 publicações atenderam aos critérios de análise e foram selecionadas para o estudo. Diante dos estudos selecionados, encontramos 52 ferramentas utilizadas na avaliação, dentre eles, os mais utilizados nos programas de perda de peso foram respectivamente o Beck Depression Inventory – BDI (Inventário de Depressão de Beck); o Binge Eating Scale - BES (Escala de Compulsão Alimentar Periódica - TCAP); e a Escala Hospitalar de Ansiedade e Depressão – HADS. Essa pesquisa nos dá evidências importantes para elaboração instrumentos específicos do tratamento da obesidade no Brasil.

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Effects of a Weight Loss Program on Metabolic Syndrome, Eating Disorders and Psychological Outcomes: Mediation by Endocannabinoids

Cited by 16 publications

References 41 publications

Effects of a High-Protein Diet on Cardiometabolic Health, Vascular Function, and Endocannabinoids—A PREVIEW Study

Effects of a High-Protein Diet on Cardiometabolic Health, Vascular Function, and Endocannabinoids—A PREVIEW Study

Physical and mental health outcomes of an integrated cognitive behavioural and weight management therapy for people with an eating disorder characterized by binge eating and a high body mass index: a randomized controlled trial

Instrumentos utilizados na avaliação psicológica no tratamento da obesidade: revisão integrativa

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