Effects of a Vitamin Pool (Vitamins A, E, and C) on the Tissue Necrosis Process: Experimental Study on Rats

Abstract

During surgical procedures on the epidermis, either aesthetic or reconstructive, the medical literature shows that certain technical standards and skin flap proportions should be followed, unless the risk of necrosis increases, in different degrees, directly related to the trauma. This study evaluates the evolution of skin flaps on the dorsum of rats treated with a vitamin pool (VP) (vitamins A, E, and C). Twenty-six rats, divided into two groups, were used: (A) the treated group (13 specimens), in which we performed a dorsal skin flap and applied the VP, and (B) the control group (13 specimens), in which we performed a flap on the dorsum without application of the VP. Our results demonstrate that, at the macroscopic level, the group treated with the VP had more tissue sufferance, whereas at the microscopic level, small statistical differences were observed between the groups and also between the vertex and the middle of the flap. Despite these small differences, better results were obtained in group A, showing that in this study the clinical aspect did not correspond to the histological features.

Wound Healing Dressings and Drug Delivery Systems: A Review

“…In addition, vitamin C aids in improving immune function particularly during infection 24, 180. The use of vitamins E and C acid has been reported to help accelerate wound healing 181. Vitamin E is also capable of preserving important morphological and functional features of biological membranes159 though its use in topical applications has however, been discouraged due to the problem of contact dermatitis 182.…”

The protective effect of melatonin on ischemia–reperfusion injury in the groin (inferior epigastric) flap model in rats

“…In the etiology of the I/R injury, a vascular thrombosis secondary to an imperfect technique, former disease in recipient or donor vessel (atherosclerosis), poor selection of recipient vessel (within the zone of injury and prone to spasm), arterial hypotension or a hypercoagulable state are contributory processes. Whatever the etiology, there have been two approaches to try to rescue the free flap: (a) early detection and rectification of the problem; (b) improvement of flap tolerance to I/R injury [1] by exogenous application of superoxide dismutase (SOD), allopurinol [7], catalase (CAT) [8], vitamin C [9], vitamin E, vitamin A [10], dexamethasone [11], heparin [12], deferroxamine [13], sulfatide [14], aprotinin [15], monoclonal antibodies [16], fucoidin [17], and melatonin [18].…”

Antioxidant mix: A novel pulpotomy medicament: A scanning electron microscopy evaluation

“…Several studies on antioxidants were found to improve healing ability. [1617] Success in the present study shows that a combination of antioxidants comprising Vitamin A, B, and C along with trace elements like zinc are capable in radicular tissue repair and regeneration.…”