Effects of a vinegar-based multi-micronutrient supplement in rats: A multi-pronged assessment of dietary impact

Abstract

We determined the effects of continuous access to drinking of water with a vinegar-based multi-micronutrient (VMm) supplement containing rice and fruit vinegars, vitamins, organic acids and sugars during gestation, lactation, and early adulthood in rats. Pregnant rats were provided with reverse-osmosis water or VMm water from the start of pregnancy through the time of weaning. Weaned pups consumed the same drinking water for 3–12 additional weeks. We examined fecal metabolite and microbial profiles, and other physiological parameters. Body weights were less in rats that drank VMm water. Thirty fecal metabolites involved in amino acid and dipeptide metabolism were significantly altered in VMm-supplemented rats. Analysis of microbial 16S rRNA showed enrichment of bacteria in the family S24–7 in VMm-supplemented rats, and one in Ruminococcaceae in controls. Our data show that a VMm-containing beverage can alter growth, and gut metabolism and microbial community. Future work to correlate these parameters is warranted.

Daily Vinegar Ingestion Improves Depression Scores and Alters the Metabolome in Healthy Adults: A Randomized Controlled Trial

“…Metabolic pathway analysis revealed significant alterations in tryptophan metabolism in the vinegar group relative to controls. In rats, metabolomics analysis of urine also identified a change in tryptophan metabolism in the vinegar treated animals in comparison to controls [12]. These data are intriguing given the antioxidant role of indole-3-acetic acid in biological systems, including brain, and the well-documented role of tryptophan in production of the stress-alleviating neurotransmitter serotonin [13][14][15].…”

Gut Protective Effect from D-Methionine or Butyric Acid against DSS and Carrageenan-Induced Ulcerative Colitis

“…In addition, the disruption of the gut epithelium might be associated with the elevated lipopolysaccharide (LPS) level [33]. The previous results have shown that chemotherapy-associated gastrointestinal toxicity is related to the increased relative abundance of LPS-producing bacteria [34].…”

Gut Protective Effect from Newly Isolated Bacteria as Probiotics against Dextran Sulfate Sodium and Carrageenan-Induced Ulcerative Colitis

“…Furthermore, the disruption of the gut epithelium might be linked to the elevated lipopolysaccharide (LPS) levels [ 27 ]. For example, it has been reported that chemotherapy-associated gastrointestinal toxicity might be related to the abundance of the LPS-producing bacteria [ 28 ]. It is plausible that both Bact A and Bact B could disturb the growth of such harmful bacteria in the gut.…”