Effects of a traditional herbal medicine on peripheral blood flow in women experiencing peripheral coldness: a randomized controlled trial

Nishida, Shinji; Eguchi, Eri; Ohira, Tetsuya; Kitamura, Akihiko; Kato, Yukiko; Hagihara, Keisuke; Iso, Hiroyasu

doi:10.1186/s12906-015-0617-4

Cited by 23 publications

(28 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lycium and LLA induced the different effects on the recovery of skin surface temperature and body temperature after cold stress in mice, there were similar with royal jelly, a honey bee secretion, which was beneficial to the recovery of skin surface temperature in women [7]. The etiology of cold syndrome could be associated with decreased peripheral blood flow [5], indeed, the average recovery of the plantar or tail skin blood flow by lycium-or LLA-treatment were well over the control group (Figure. 4 and Figure.…”

Section: Discussionmentioning

confidence: 88%

See 1 more Smart Citation

Effects of lycium and lycium-composed formula on the peripheral coldness induced by local cooling in mice

Zhou

Ishikawa

Nakashima

et al. 2016

ijpm

View full text Add to dashboard Cite

Recently people appealing for peripheral coldness increase. Lycium fruits have a long tradition of use in nutrition and traditional medicine in East Asia, while its effect on peripheral coldness is not yet investigated. We study the effects of lycium and lycium-rich formula (Ligustrum lucidum ait, LLA) on the peripheral coldness induced by local cooling in mice.7-week old male ddY mice were administered either water (control) or lycium or LLA for 2 weeks. After an aesthesia, the mouse body except for head was immersed into 10 ℃ water for 10 min. Then the skin surface and rectal temperature of mouse were measured with a thermocamera and a thermocouple thermometer, respectively. And two laser Doppler flow probes were set to measure the skin blood flow of plantar and tail, respectively.In the case of 1-week administration on mice, 10% lycium- and 10% LLA-treatments showed good recovery of whole body surface temperature measured by a thermocamera. After 2-week administration on mice, there were not significant differences in the recovery rates of rectal temperature compared with those of the control group. And the 30 min- and 50 min-recovery rates of dorsal skin surface temperature by 1% and 10% lycium-treatment were significantly higher than those of the respective control. Further, the 30 min- and 50 min-plantar skin blood flow by 10% LLA-treatment were significantly higher than those of the respective control. The 50 min-tail skin blood flow by 10% LLA-treatment and 60 min-tail skin blood flow by 1% LLA-treatment were significantly higher than those of the control, respectively.It can be concluded that the administration of lycium or LLA on mouse led to an increase of peripheral blood blow, and thus a recovery of skin surface temperature.

show abstract

Section: Discussionmentioning

confidence: 88%

“…, thermoregulation, blood flow, lycium vessels and increased the blood flow under cold stress [5,6,7]. have a long tradition of use in nutrition and traditional medicine in East Asia.…”

Section: -359mentioning

confidence: 99%

Effects of lycium and lycium-composed formula on the peripheral coldness induced by local cooling in mice

Zhou

Ishikawa

Nakashima

et al. 2016

ijpm

View full text Add to dashboard Cite

show abstract

“… 17 , 18 Some studies, however, do not include it as a criterion and use it when evaluating improvement or severity. 19 And the difference of measurement point such as fingertip and palm could be a factor of disagreement. 16 , 17 , 18 , 19 Some experts claimed that it is more appropriate to examine the hands and feet as a whole, since patients complain of coldness either in the tips of fingers or in the palm of the hands.…”

Section: Discussionmentioning

confidence: 99%

“… 19 And the difference of measurement point such as fingertip and palm could be a factor of disagreement. 16 , 17 , 18 , 19 Some experts claimed that it is more appropriate to examine the hands and feet as a whole, since patients complain of coldness either in the tips of fingers or in the palm of the hands. To overcome these limitations, DITI analysis should be improved to measure and compare temperatures anywhere of the body.…”

Section: Discussionmentioning

confidence: 99%

The definition and diagnosis of cold hypersensitivity in the hands and feet: Finding from the experts survey

Bae

Jeong

et al. 2018

Integrative Medicine Research

View full text Add to dashboard Cite

BackgroundCold hypersensitivity in the hands and feet (CHHF) is a symptom patients usually feel cold in their hands and feet, but not dealt with a disease in western medicine. However, it is often appealed by patients at a clinic of Korean medicine (KM), considered to be a sort of key diagnostic indicator, and actively treated by physicians. Nevertheless, there is no standardized diagnostic definition for CHHF. Therefore, we surveyed KM experts’ opinions to address the clinical definition, diagnostic criteria, and other relevant things on CHHF.MethodsWe developed a survey to assess the definition, diagnosis, causes, and accompanying symptoms on CHHF. 31 experts who work at specialized university hospitals affiliated with KM hospitals consented to participation. Experts responded to survey questions by selecting multiple-choice answers or stating their opinions.ResultsVast majority of experts (83.8%) agreed with our definition on CHHF (“a feeling of cold as a symptom; that one's hands or feet become colder than those of average people in temperatures that are not normally perceived as cold”). 77.4% of experts considered subjective symptoms on CHHF were more important than medical instrument results. Constitution or genetic factors (87.1%) and stress (64.5%) were the most common causes reported for CHHF.ConclusionsThis study offers an expert consensus regarding the themes, opinions, and experiences of practitioners with CHHF. Our results underscore the need for standardized definitions and diagnostic criteria for CHHF.

show abstract

“…We believe that this is because menopausal disorder has symptoms that can be clearly classified as a cold or heat pattern, such as hot flushes, hypersensitivity to cold, palpitations, and edema 17 . The top 10 diseases included diseases with characteristics of cold and heat, such as coldness in the hands and feet 18 and hwa-byung (a “fire disease”) 19 . Other diseases with a clear cold or heat pattern were chronic rhinitis, characterized by clear and turbid rhinorrhea, and atopic dermatitis with blood-heat 20 or dampness-heat 21 …”

Section: Discussionmentioning

confidence: 99%

Perception of cold and heat pattern identification in diseases: a survey of Korean medicine doctors

Bae

Lee

Park

et al. 2017

Integrative Medicine Research

View full text Add to dashboard Cite

BackgroundThis study aimed to investigate the extent to which Korean Medicine doctors consider cold and heat pattern identification when prescribing herbal treatment for a disease.MethodsA survey was sent by e-mail to 15,841 members of the Association of Korean Medicine for whom member information was registered. Of these, 699 (4.4%) members participated in the survey. The survey included questions regarding the frequency of use of cold and heat pattern identification in deciding a herbal treatment prescription, the diseases for which cold and heat pattern identification-related herbal treatment was most efficacious, the type of herbal treatment prescribed, and the duration of the treatment.ResultsOf the 699 respondents, 591 (84.5%) reported that they considered cold and heat when prescribing herbal treatment. The diseases for which consideration of cold and heat patterns was effective were, in order, menopausal disorder (124, 18.3%), chronic rhinitis (98, 14.5%), dyspepsia (94, 13.9%), hwa-byung (92, 13.6%), diarrhea (83, 12.3%), dysmenorrhea (61, 9.0%), headache (59, 8.7%), inflammation in the digestive tract (58, 8.6%), coldness in hands and feet (58, 8.6%), and atopic dermatitis (55, 8.1%). The typical treatment duration differed widely for different diseases: atopic dermatitis was most frequently treated for >2 months (38, 34.5%), whereas diarrhea was most frequently treated for ≤ 10 days (73, 43.6%).ConclusionThese findings indicate that cold and heat pattern identification is a useful tool employed by Korean Medicine doctors. This study may provide a basis for clinical research investigating the effect of pattern identification-based treatment of diseases.

show abstract

Effects of a traditional herbal medicine on peripheral blood flow in women experiencing peripheral coldness: a randomized controlled trial

Cited by 23 publications

References 14 publications

Effects of lycium and lycium-composed formula on the peripheral coldness induced by local cooling in mice

Effects of lycium and lycium-composed formula on the peripheral coldness induced by local cooling in mice

The definition and diagnosis of cold hypersensitivity in the hands and feet: Finding from the experts survey

Perception of cold and heat pattern identification in diseases: a survey of Korean medicine doctors

Contact Info

Product

Resources

About