Effects of a Topical Saffron (<i>Crocus sativus</i> L) Gel on Erectile Dysfunction in Diabetics

Mohammadzadeh-Moghadam, Hossein; Nazari, Seyed Mohammad; Shamsa, Ali; Kamalinejad, Mohammad; Esmaeeli, Habibollah; Asadpour, A.; Khajavi, Abdoljavad

doi:10.1177/2156587215583756

Cited by 24 publications

(12 citation statements)

References 11 publications

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“…Saffron tea has been reputed to be a potential complementary treatment for psoriasis in medical nutrition therapy [13]. Many pharmacological studies have shown that this plant and its phytochemicals have emerged as nutraceutical elements, endowed with beneficial effects on health showing antibacterial [14], antioxidant, cytotoxic [15,16], antifungal [17], immunomodulatory [18,19], anti-mutagenic [20], aphrodisiac [21], antitussives [22,23], and antiplatelet effects [24]. Traditional and modern biomedical reports have also proved saffron to cure coronary artery diseases [25], respiratory diseases [26], menstrual disorders [27,28], and neurodegenerative disorders [29].…”

Section: Introductionmentioning

confidence: 99%

Potential Nutraceutical Benefits of In Vivo Grown Saffron (Crocus sativus L.) As Analgesic, Anti-inflammatory, Anticoagulant, and Antidepressant in Mice

Khan

Muhamad

Ismail

et al. 2020

Plants

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Crocus sativus, a medicinally important herbaceous plant, has been traditionally used to cure coughs, colds, insomnia, cramps, asthma, and pain. Moreover, the therapeutic applications of saffron include its immunomodulatory and anticancer properties. The current experimental analysis was performed to explore the potential nutraceutical efficacy of corm, leaf, petal, and stigma of saffron ethanolic extracts as analgesic, anti-inflammatory, anticoagulant, and antidepressant using hot plate, carrageenan-induced paw edema, capillary tube and forced swim test, respectively in mice. The results indicated that among all the extracts, stigma ethanolic extract (SEE) represented maximum latency activity (72.85%) and edema inhibition (77.33%) followed by petal ethanolic extract (PEE) with latency activity and edema inhibition of 64.06 and 70.50%, respectively. Corm ethanolic extract (CEE) and leaf ethanolic extract (LEE) displayed mild analgesic activity of 22.40% and 29.07%, respectively. Additionally, LEE (53.29%) and CEE (47.47%) exhibited mild to moderate response against inflammation. The coagulation time of SEE (101.66 s) was almost equivalent to the standard drug, aspirin (101.66 s), suggesting a strong anticoagulant effect followed by PEE (86.5 s). LEE (66.83 s) represented moderate inhibitory effect on coagulation activity while CEE (42.83 s) showed neutral effect. Additionally, PEE and SEE also expressed itself as potential antidepressants with immobility time ≤76.66 s, while CEE (96.50 s) and LEE (106.83 s) indicated moderate to mild antidepressant efficacy. Based on the in vivo activities, saffron extract, particularly SEE and PEE, can be used as a potential nutraceutical and therapeutic agent due to its significant pharmacological activities.

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Section: Introductionmentioning

confidence: 99%

Potential Nutraceutical Benefits of In Vivo Grown Saffron (Crocus sativus L.) As Analgesic, Anti-inflammatory, Anticoagulant, and Antidepressant in Mice

Khan

Muhamad

Ismail

et al. 2020

Plants

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“…Several studies have evaluated the effects of crocin intake on sexual functions in individuals not undergoing MMT, though data on the effects of crocin administration on sexual function in patients under MMT are scarce. Saffron administration significantly improves erectile dysfunction in diabetic patients [40]. In a study conducted by Shamsa et al [20], oral saffron administration at a dose of 200 mg/day for 10 days improved erectile function in males suffering from erectile dysfunction [41].…”

Section: Discussionmentioning

confidence: 99%

The effects of crocin on psychological parameters in patients under methadone maintenance treatment: a randomized clinical trial

Khalatbari-mohseni

Banafshe

Mirhosseini

et al. 2019

Subst Abuse Treat Prev Policy

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Background Methadone maintenance treatment (MMT) might be associated with the symptoms of depression and anxiety, sleep disturbances and sexual dysfunctions. This study was designed to determine the effects of crocin on psychological parameters in patients under MMT. Methods Patients under MMT were randomly allocated into two groups to receive either 30 mg/day crocin (2 plus crocin tablet, 15 mg BID) ( n = 25) or placebo (2 tablets per day, 15 mg BID) ( n = 25), one hour after taking food, for 8 weeks. Psychological parameters were evaluated at baseline and end of the trial to determine related associations between crocin and patients’ mental health status. Results After 8-week intervention, crocin significantly decreased Beck Depression Inventory (b − 6.66; 95% CI, − 9.88, − 3.45; P < 0.0001), Beck Anxiety Inventory (b − 4.35; 95% CI, − 5.94, − 2.75; P < 0.0001), general health questionnaire (b − 4.45; 95% CI, − 7.68, − 1.22; P = 0.008) and Pittsburgh Sleep Quality Index (b − 2.73; 95% CI, − 3.74, − 1.73; P < 0.0001) in patients under MMT, compared with the placebo. Crocin also significantly improved International Index of Erectile Functions (b 4.98; 95% CI, 2.08, 7.88; P = 0.001) rather than placebo. Conclusion Our findings indicated that taking crocin for 8 weeks by patients under MMT had beneficial effects on their mental health status. Crocin can be recommended as an adjunct to methadone in opioid withdrawal protocols because of the ability to improve the quality of life and decrease opioids side effects in these patients. This trial was registered in the Iranian website for clinical trials registry as http://www.irct.ir : IRCT2017110537243N1. Clinical trial registration number www.irct.ir: http://www.irct.ir: IRCT2017110537243N1 .

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“…That study demonstrated that use of 15 mg C. sativus twice a day caused improvement of erectile dysfunction in these men 33 . In patients with diabetes, the local application of C. sativus gel leads to treatment of erectile dysfunction 36 . A study reported that treatment with 200 mg of C. sativus a day improved tip rigidity and tip tumescence as well as base rigidity and base tumescence in studied people 37 .…”

Section: Libido-boosting Plant-based Compoundsmentioning

confidence: 99%

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2017

IJPSR

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Medicinal plants used in traditional medicine and various cultures can be valuable resources for discovering new drugs. This review was conducted to report Iranian medicinal plants effective on sexual dysfunction (sexual desire disorders, erectile dysfunction, and premature ejaculation). To conduct this systematic review, the search terms Sexual*, Aphrodisiacs, Erectile, and Libido* combined with Medicinal plants, Herb*, and Phyto* were used to retrieve relevant publications from the databases International Scientific Institute, PubMed, Scopus, and EBSCO. Tribulus terrestris, Rosa damascena, Crocus sativus L., rosmarinic acid, and crocin are a number of medicinal plants and their derivatives that have libidoboosting properties. C. sativus, Zingiber officinale, and Peganum harmala are some of the plants that exert therapeutic effects on erectile dysfunction. Boswellia serrata and Lavandula angustifolia are two plants used to treat premature ejaculation. Medicinal plants that are used to treat sexual dysfunctions in Iran can help to improve sexual desire disorders, erectile dysfunction, and premature ejaculation through certain mechanisms such as affecting the cerebral neurotransmitters and sex cells, increasing physical strength, causing hormonal changes, and affecting neurons and certain parts of the brain. They can be used to discover and produce new effective drugs for sexual dysfunction.

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Effects of a Topical Saffron (Crocus sativus L) Gel on Erectile Dysfunction in Diabetics

Cited by 24 publications

References 11 publications

Potential Nutraceutical Benefits of In Vivo Grown Saffron (Crocus sativus L.) As Analgesic, Anti-inflammatory, Anticoagulant, and Antidepressant in Mice

Potential Nutraceutical Benefits of In Vivo Grown Saffron (Crocus sativus L.) As Analgesic, Anti-inflammatory, Anticoagulant, and Antidepressant in Mice

The effects of crocin on psychological parameters in patients under methadone maintenance treatment: a randomized clinical trial

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