Effects of a three‐month combined exercise programme on fibroblast growth factor 21 and fetuin‐A levels and arterial stiffness in obese women

Yang, Sae Jeong; Hong, Ho Cheol; Choi, Hee Youn; Yoo, Hye Jin; Cho, Geum-Joon; Hwang, Teak Geun; Baik, Sei-Hyun; Choi, Dong Seop; Kim, Seon Mee; Choi, Kyung Mook

doi:10.1111/j.1365-2265.2011.04078.x

Cited by 124 publications

(117 citation statements)

References 34 publications

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“…While 3 months of combined aerobic and resistance exercise diminished FGF21 serum levels [116], 2 months endurance training had no effect on FGF21 serum levels or FGF21 mRNA expression in skeletal muscle [117]. Most interestingly, 2 weeks of daily endurance training and an acute bout of endurance exercise enhanced circulating FGF21 levels and this was accompanied by increased serum levels of NEFA [118,119].…”

Section: Key Facts: Myokines As Therapeutic Targetsmentioning

confidence: 83%

Myokines in insulin resistance and type 2 diabetes

et al. 2014

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Skeletal muscle represents the largest organ of the body in non-obese individuals and is now considered to be an active endocrine organ releasing a host of so-called myokines. These myokines are part of a complex network that mediates communication between muscle, the liver, adipose tissue, the brain and other organs. Recent data suggest that myokines regulated by muscle contraction may play a key role in mediating the health-promoting effects of regular physical activity. Although hundreds of myokines have recently been described in proteomic studies, we currently have a rather limited knowledge of the specific role these myokines play in the prevention of insulin resistance, inflammation and associated metabolic dysfunction. Several myokines are known to have both local and endocrine functions, but in many cases the contribution of physical activity to the systemic level of these molecules remains as yet unexplored. Very recently, novel myokines such as irisin, which is thought to induce a white to brown shift in adipocytes, have gained considerable interest as potential therapeutic targets. In this review, we summarise the most recent findings on the role of myokines in the regulation of substrate metabolism and insulin sensitivity. We further explore the role of myokines in the regulation of inflammation and provide a critical assessment of irisin and other myokines regarding their potential as therapeutic targets.

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Section: Key Facts: Myokines As Therapeutic Targetsmentioning

confidence: 83%

Myokines in insulin resistance and type 2 diabetes

et al. 2014

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“…In studies on human have shown that lipolysis inhibition in adipocytes takes place by FGF21 (Arner et al, 2008), while other findings have indicated that high level of serum FGF21 associated with abdominal adiposity, insulin resistance, high level of triglyceride and type 2 diabetes (Jian et al, 2012;Chavez et al, 2009;Dushay et al, 2010;Galman et al, 2008;Li et al, 2012;Zhang et al, 2008). It is reported that FGF21 are associated with metabolic syndrome patients , type 2 diabetes (Li et al, 2010), impaired glucose tolerance (Chavez et al, 2009), nonalcoholic fatty liver disease (Dushay et al, 2010;Li et al, 2011;Yilmaz et al, 2010;An et al, 2012) and carotid artery disease (Yang et al, 2011; Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults, 2001). Effect of FGF21 in human on metabolic syndrome patients is not exactly clear.…”

Section: Introductionmentioning

confidence: 99%

Serum Level of Fibroblast Growth Factor 21 in Type 2 Diabetic Patients with and without Metabolic Syndrome

Shafaei¹,

Khoshnia²,

Marjani³

2015

J. of Medical Sciences

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Effect of FGF21 on metabolic syndrome patients is not exactly clear. In the present study, we assessed serum level of fibroblast growth factor 21 in type 2 diabetic patients with and without metabolic syndrome in Gorgan. The study groups consisted of 120 patients with type 2 diabetes and 60 healthy subjects. Diabetic patients divided into two groups. All subjects were matched according to age and sex. The mean waist circumference, systolic and diastolic blood pressure, triglyceride and fasting blood glucose levels and body mass index were significantly higher in the subjects with metabolic syndrome than control group, but the mean HDL-cholesterol was significantly lower (p = 0.0001). Mean serum level of FGF21 was higher in type 2 diabetic subjects with and without metabolic syndrome than that of control subject (p = 0.0001). There were significant negative correlation between FGF21 and BMI, diastolic blood pressure and HDL-cholesterol in subjects with metabolic syndrome (p<0.05). There were also significant negative correlation between FGF21 and cholesterol and HDL-cholesterol in control group (p<0.05). The findings of this study suggest that serum FGF21 are higher in patients with type 2 diabetes with and without metabolic syndrome than in age and sex matched control group. Our study shows that some of metabolic syndrome components (especially HDL-cholesterol) are associated with high serum FGF21 levels. Because of different effects of FGF21 in rodents, primates and in humans, it may require more investigating on metabolic effects of FGF21 in human's samples.

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“…Next, we performed a prospective study to examine the effect of a 3-month combined exercise program on circulating glypican-4 levels in 64 obese women. Details of the inclusion criteria for this prospective study and of the combined exercise program were provided in our previous report (8). All participants provided their written informed consent and the Korea University Institutional Review Board, in accordance with the Declaration of Helsinki of the World Medical Association, approved the study protocol.…”

Section: Study Design and Participantsmentioning

confidence: 99%

Association of Glypican-4 With Body Fat Distribution, Insulin Resistance, and Nonalcoholic Fatty Liver Disease

Yoo

Hwang

Cho³

et al. 2013

The Journal of Clinical Endocrinology &Amp; Metabolism

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Context and Objective:Glypican-4 was identified as a novel adipokine capable of enhancing insulin signaling and modulating adipocyte differentiation. We investigated associations between glypican-4 and body composition, insulin resistance, arterial stiffness, and nonalcoholic fatty liver disease (NAFLD) in nondiabetic Asian subjects. Design and Participants:We analyzed baseline cross-sectional data from the Korean Sarcopenic Obesity Study, an ongoing prospective cohort study. NAFLD was diagnosed by unenhanced computed tomography using the liver attenuation index. We also examined the effects of a 3-month combined aerobic and resistance exercise program on glypican-4 levels and cardiometabolic risk factors. Results:Circulating glypican-4 levels were higher in men than in women (1.83 [1.19, 2.78] ng/mL vs 1.17 [0.66, 2.00] ng/mL, P Ͻ .001) and had a significant positive relationship with the waist-to-hip ratio (WHR) (r ϭ 0.20, P ϭ .014) and the ratio of visceral to sc fat area (r ϭ 0.30, P Ͻ .001). Furthermore, glypican-4 levels in women were correlated with cardiometabolic risk factors, including insulin resistance and arterial stiffness, and were independently associated with NAFLD by multiple logistic regression analysis (P ϭ .017, R 2 ϭ 0.33). The 3-month combined exercise training program significantly improved several cardiometabolic parameters and reduced retinol binding protein-4 levels. Changes in glypican-4 levels after the exercise program were significantly different between subjects with an increased WHR compared with those with a decreased WHR (P ϭ .034). Conclusion:A gender-based difference in circulating glypican-4 levels was apparent as these were increased in women with NAFLD and related to body fat distribution, insulin resistance, and arterial stiffness. A dipose tissue plays an important role in controlling systemic energy homeostasis through the secretion of various adipokines that interact with the brain, pancreas, skeletal muscle, and liver (1). Because visceral adipose tissue is more pathogenic than sc adipose tissue, the site of fat accumulation plays a pivotal role in metabolic disorders (2). However, little is known about the factors that determine sites of fat accumulation. Recently, Gesta et al found that glypican-4 is differentially expressed in visceral and sc adipose tissue, and that its expression in Abbreviations: AST, aspartate aminotransferase; baPWV, brachial ankle pulse wave velocity; BMI, body mass index; HOMA-IR, homeostasis model assessment of insulin resistance; NAFLD, nonalcoholic fatty liver disease; VFA/SFA, ratio of visceral to sc fat area; WHR, waist-to-hip ratio.

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Effects of a three‐month combined exercise programme on fibroblast growth factor 21 and fetuin‐A levels and arterial stiffness in obese women

Abstract: A 3-month combined exercise programme decreases the FGF21 levels as well as arterial stiffness in obese Korean women.

Cited by 124 publications

References 34 publications

Myokines in insulin resistance and type 2 diabetes

Myokines in insulin resistance and type 2 diabetes

Serum Level of Fibroblast Growth Factor 21 in Type 2 Diabetic Patients with and without Metabolic Syndrome

Association of Glypican-4 With Body Fat Distribution, Insulin Resistance, and Nonalcoholic Fatty Liver Disease

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