Effects of a subconvulsant dose of kainic acid on afterdischarges elicited by cortical stimulation in rats

Koryntová, H; Šlapal, Radomír; Langmeier, M; Haugvicová, Renata; Mareš, Pavel

doi:10.1016/s0920-1211(97)00059-4

Cited by 20 publications

(9 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is in agreement with our other data: a subconvulsive dose of KA led to changes in the thresholds for elicitation of cortical epileptic afterdischarges in adult rats (17,18) and to changes in elevated plus maze performance in immature animals (20). These findings are in sharp contrast to the literature, where even in adult animals motor seizures are taken as a necessary prerequisite of functional and morphological changes after KA administration.…”

Section: Figsupporting

confidence: 92%

“…Data on consequences of nonconvulsive seizures that do not progress into motor seizures are scarce. We started to study this problem in adult rats and our results indicate acute as well as longer-lasting changes in electrophysiological (cortical afterdischarges (17,18)) as well as behavioral (open field (19), elevated plus maze (20)) measures. The aim of the present study was to analyze possible functional changes after kainic acid-induced nonconvulsive seizures in rat pups.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nonconvulsive Seizures Result in Behavioral but Not Electrophysiological Changes in Developing Rats

Kubová

Mikulecká

Haugvicová

et al. 2001

Epilepsy & Behavior

View full text Add to dashboard Cite

Section: Figsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Nonconvulsive Seizures Result in Behavioral but Not Electrophysiological Changes in Developing Rats

Kubová

Mikulecká

Haugvicová

et al. 2001

Epilepsy & Behavior

View full text Add to dashboard Cite

“…To study the contribution of different newborn granule cell populations generated after SE to epileptogenesis, future studies will need to focus on discriminating between their differential intrinsic properties derived from varying seizure intensities. The level of seizure severity can be regulated in some rodent models of epilepsy, including kindling models and/or SE models (either chemically or electrically induced) (Milgram et al, 1995;Koryntova et al, 1997).…”

Section: A Proposal For An Integrative Hypothesismentioning

confidence: 99%

Different subsets of newborn granule cells: a possible role in epileptogenesis?

Bielefeld

Vliet

Gorter

et al. 2013

Eur J of Neuroscience

View full text Add to dashboard Cite

Several factors, including epileptic seizures, can strongly stimulate ongoing neurogenesis in the adult hippocampus. Although adult-born granule cells generated after seizure activity have different physiological properties from their normal counterparts, they integrate into the existing, mature network of the adult hippocampal dentate gyrus. However, the exact role of the neurogenic response during epilepsy and its possible involvement in epileptogenesis have remained elusive. Here, we discuss recent studies shedding new light on the interplay between epilepsy and neurogenesis, and try to explain discrepancies in this literature by proposing seizure severity-dependent induction of two subsets of newborn cells with different properties. We hypothesise that a low seizure intensity would stimulate neurogenesis to a 'physiological plasticity' level and have few pathological consequences. In contrast, a high initial seizure intensity may induce a specific subset of altered and/or ectopically located new granule cells with different electrophysiological properties that could initiate hyperexcitatory recurrent networks that could, in turn, contribute to chronic epilepsy. This hypothesis may clarify previously contradictory data in the literature, and could thereby aid in our understanding of the role of neurogenesis in epileptogenesis, and open up promising avenues for therapeutic intervention.

show abstract

“…s) kova! et al 1999) as well as for studies of a role of neurotransmitter systems in epileptogenesis (Koryntova! et al 1997 ; Berna!…”

Section: Introductionmentioning

confidence: 99%

Effects of classical antiepileptics on thresholds for phenomena induced by cortical stimulation in rats

Haugvicová

Bílková

Kubová

et al. 2002

Journal of Pharmacy and Pharmacology

Self Cite

View full text Add to dashboard Cite

Our aim was to study the effects of phenobarbital, phenytoin and ethosuximide on epileptic afterdischarges induced by cortical stimulation in rats. Fifteen-second series of low-frequency (8 Hz) rhythmic stimulation of the sensorimotor cortex were applied in rats with chronically implanted electrodes. Intervals between the stimulation series were at least 10 min and intensity was increased in a step-wise manner. Threshold current intensities were estimated for movements directly induced by stimulation, epileptic afterdischarges of the spike-and-wave type, clonic seizures accompanying this type of afterdischarge and transition into the limbic type of afterdischarge. Phenobarbital, phenytoin and ethosuximide were administered intraperitoneally before the first stimulation series. Phenobarbital (20, 40 and 80 mg kg(-1)) significantly increased the thresholds for the first three phenomena in a dose-dependent manner. Transition into the limbic afterdischarge was influenced only by the highest dose. Phenytoin (60 mg kg(-1)) only increased the thresholds insignificantly and ethosuximide (125 mg kg(-1)) was ineffective. We concluded that our model is useful for testing anticonvulsant effects. Results with three antiepileptic drugs correspond with their efficacy against myoclonic seizures in man.

show abstract

Effects of a subconvulsant dose of kainic acid on afterdischarges elicited by cortical stimulation in rats

Cited by 20 publications

References 26 publications

Nonconvulsive Seizures Result in Behavioral but Not Electrophysiological Changes in Developing Rats

Nonconvulsive Seizures Result in Behavioral but Not Electrophysiological Changes in Developing Rats

Different subsets of newborn granule cells: a possible role in epileptogenesis?

Effects of classical antiepileptics on thresholds for phenomena induced by cortical stimulation in rats

Contact Info

Product

Resources

About