Effects of a Structured Exercise Program on Physical Activity and Fitness in Colon Cancer Survivors: One Year Feasibility Results from the CHALLENGE Trial

Courneya, Kerry S.; Vardy, Janette; O’Callaghan, Christopher J.; Friedenreich, Christine M.; Campbell, Kristin L.; Prapavessis, Harry; Crawford, Jennifer; O’Brien, P.; Dhillon, Haryana M.; Jonker, Derek J.; Chua, Neil; Lupichuk, Sasha; Sanatani, Michael; Gill, Sharlene; Meyer, Ralph M.; Begbie, Stephen; Bonaventura, Tony; Burge, Matthew; Turner, Jane; Tu, Dongsheng; Booth, Christopher M.

doi:10.1158/1055-9965.epi-15-1267

Cited by 81 publications

(78 citation statements)

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“…The Colon Health and Life‐Long Exercise Change (CHALLENGE) Trial is the first phase 3 trial examining the effects of a 3‐year structured PA program on disease‐free survival in patients with stage II and III colon cancer who have recently completed chemotherapy . To date, the trial has demonstrated feasibility in accrual and PA behavior change; it has randomized over 590 of the planned 962 patients. The Intense Exercise for Survival (INTERVAL) Trial is another phase 3 trial examining the effects of a 2‐year structured PA program on overall survival in 866 men with metastatic, castrate‐resistant prostate cancer .…”

Section: Body Weight Pa and Health Outcomes For Cancer Survivors: Kmentioning

confidence: 99%

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Weight management and physical activity throughout the cancer care continuum

Demark‐Wahnefried

Schmitz

Alfano

et al. 2017

CA A Cancer J Clinicians

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129

122

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Mounting evidence suggests that weight management and physical activity (PA) improve overall health and well being, and reduce the risk of morbidity and mortality among cancer survivors. Although many opportunities exist to include weight management and PA in routine cancer care, several barriers remain. This review summarizes key topics addressed in a recent National Academies of Science, Engineering, and Medicine workshop entitled, "Incorporating Weight Management and Physical Activity Throughout the Cancer Care Continuum." Discussions related to body weight and PA among cancer survivors included: 1) current knowledge and gaps related to health outcomes; 2) effective intervention approaches; 3) addressing the needs of diverse populations of cancer survivors; 4) opportunities and challenges of workforce, care coordination, and technologies for program implementation; 5) models of care; and 6) program coverage. While more discoveries are still needed for the provision of optimal weight-management and PA programs for cancer survivors, obesity and inactivity currently jeopardize their overall health and quality of life. Actionable future directions are presented for research; practice and policy changes required to assure the availability of effective, affordable, and feasible weight management; and PA services for all cancer survivors as a part of their routine cancer care. CA Cancer J Clin 2018;68:64-89. © 2017 American Cancer Society.

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Section: Body Weight Pa and Health Outcomes For Cancer Survivors: Kmentioning

confidence: 99%

“…More recently, hybrid programs that are able to support sustained PA have emerged. Generally, these programs begin with an on‐site, supervised phase and then taper to an off‐site phase (eg, the CHALLENGE trial) …”

Section: Effective Approaches For Improving Weight Management and Pamentioning

confidence: 99%

Weight management and physical activity throughout the cancer care continuum

Demark‐Wahnefried

Schmitz

Alfano

et al. 2017

CA A Cancer J Clinicians

Self Cite

129

122

View full text Add to dashboard Cite

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“…Researchers have developed a 3‐year RCT exercise protocol in colon cancer, with supervised sessions, behavioral support and health education for the intervention group and health education only for the control . A 1‐year feasibility report has so far been successful . This controlled design, uniquely combining structured activity and motivational support, may provide the basis for a similar protocol in AIMSS.…”

Section: Discussionmentioning

confidence: 98%

Efficacy of management strategies for aromatase inhibitor‐induced arthralgia in breast cancer patients: a systematic review

Nahm

Mee

Marx

2018

Asia-Pac J Clncl Oncology

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Aromatase inhibitors are the gold standard in the treatment of hormone receptor-positive breast cancer, but lead to an arthralgia syndrome which is implicated in 13-22% of noncompliance. This is the first systematic review of the efficacy of existing management strategies for this side effect.Eligible studies were retrieved from computer searches of Medline, Cochrane and Embase and the significant intervention groups were identified. The risk of bias of selected studies was evaluated and the relevant data items were extracted, summarized and analyzed. A total of 21 studies were discussed in this review representing 12 different interventions. While several trials had positive findings, the major methodological limitations of the studies meant that no definitive evidence could be found supporting any of the interventions. Future trials are needed which address the methodological problems identified in this review. Exercise holds promise for future research based on its proven benefit in breast cancer.

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“…We were delighted to read the recent report by Courneya and colleagues on the 1-year feasibility and fitness benefits of a structured exercise program among colon cancer survivors in the CHALLENGE Trial (1). These findings, and the expected 3-year follow-up data, are an important contribution to the nascent body of research examining the effectiveness of sustained exercise behavior change in cancer patients.…”

Section: Letter To the Editormentioning

confidence: 99%