2016
DOI: 10.1007/s11064-016-1998-6
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Effects of a Standardized Phenolic-Enriched Maple Syrup Extract on β-Amyloid Aggregation, Neuroinflammation in Microglial and Neuronal Cells, and β-Amyloid Induced Neurotoxicity in Caenorhabditis elegans

Abstract: Published data supports the neuroprotective effects of several phenolic-containing natural products, including certain fruit, berries, spices, nuts, green tea, and olive oil. However, limited data are available for phenolic-containing plant-derived natural sweeteners including maple syrup. Herein, we investigated the neuroprotective effects of a chemically standardized phenolic-enriched maple syrup extract (MSX) using a combination of biophysical, in vitro, and in vivo studies. Based on biophysical data (Thiof… Show more

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Cited by 31 publications
(46 citation statements)
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“…20 Moreover, MSX shows neuroprotective effects in Caennorhabditis elegans and alleviate lipopolysaccharide-induced inflammation and cell stress in murine microglial and human neuronal cells. 28 As previously discussed, AGEs could trigger cell stress by inducing oxidative stress and activating inflammatory signaling pathways. 43 Therefore, in the current study, we evaluated the protective effects of MSX against AGE-induced cytotoxicity on normal/non-tumorigenic colon CCD-18Co cells.…”
Section: Resultsmentioning
confidence: 93%
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“…20 Moreover, MSX shows neuroprotective effects in Caennorhabditis elegans and alleviate lipopolysaccharide-induced inflammation and cell stress in murine microglial and human neuronal cells. 28 As previously discussed, AGEs could trigger cell stress by inducing oxidative stress and activating inflammatory signaling pathways. 43 Therefore, in the current study, we evaluated the protective effects of MSX against AGE-induced cytotoxicity on normal/non-tumorigenic colon CCD-18Co cells.…”
Section: Resultsmentioning
confidence: 93%
“…25 Therefore, we have taken a whole-food approach towards studying the biological effects of this botanical natural product as we reported in our recent evaluation of the neuroprotective effects of MSX. 28 With regards to the phenolic content of the extract, we have previously reported on the development of a maple product specific standard, named MaPLES (maple phenolic lignan-enriched standard), for the quantification of phenolic content of maple-derived food products since MSX contains predominantly lignans which cannot be adequately quantified based on gallic acid equivalents (GAEs). 35 Therefore, MSX contains 92.4% phenolic content based on MaPLES equivalents; see Supplementary Information Table S1).…”
Section: Resultsmentioning
confidence: 99%
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“…Previous studies, some recent, reported that maple syrup also contains several phytochemicals, including phenolic compounds that present hypoglycemic, antioxidant, antimutagenic, anticancer, anti-inflammatory, antibiotic and anti-neurodegenerative effects (917). Moreover, biological effects have been noted following maple syrup consumption.…”
Section: Introductionmentioning
confidence: 99%