Effects of a soy-protein beverage on plasma lipoproteins in children with familial hypercholesterolemia

Abstract

The effects of soy protein (35% of protein energy) given as a beverage and those of cow-milk proteins were investigated on plasma lipoprotein concentrations in children with familial hypercholesterolemia (FH). Subjects were randomly assigned to either the soy-protein or cow-milk-protein experimental period, with subsequent crossover after a washout period, each period lasting 4 wk. Diets were planned to provide 20% energy as protein, 28% as fat (polyunsaturated:monounsaturated:saturated fatty acids, 1:3:3) and less than 200 mg cholesterol/d. No changes were observed in either plasma cholesterol, low-density-lipoprotein cholesterol, or apolipoprotein concentrations. However, the soy beverage significantly reduced the concentrations of triglyceride and very-low-density-lipoprotein cholesterol (P less than 0.05) and significantly increased the concentrations of high-density-lipoprotein cholesterol (HDL-C) and HDL3-C (P less than 0.04 and P less than 0.03, respectively). These results indicate that the administration of soy protein may induce clinically beneficial effects in children with FH.

Drug Therapy of High-Risk Lipid Abnormalities in Children and Adolescents

“…Small studies of dietary alterations in hyperlipidemic children have shown that substitution with soy-based protein may increase HDL cholesterol and lower VLDL levels and triglycerides 129 and may lower LDL cholesterol levels. 130 Dietary enrichment with rapeseed or canola oil has been shown to lower triglyceride and VLDL levels.…”

Screening and Treatment for Lipid Disorders in Children and Adolescents: Systematic Evidence Review for the US Preventive Services Task Force

“…167,177,180,199,[249][250][251][252][253][254][255][256][257][258] Two children (4% of the treatment group) reported abdominal discomfort using fiber tablets (containing 50% wheat bran and 50% pectin) administered at 100 to 150 mg/kg per day. 180,252,255 There were no adverse effects with psyllium fiber in 2 other studies.…”

Effect of 3-month treatment of children and adolescents with familial and polygenic hypercholesterolaemia with a soya-substituted diet

“…Mean value is significantly different from that at the end of phase 1: † P, 0·001, † † P, 0·0001. (maximum 26 weeks) 8 , previous studies in children and adolescents have demonstrated a beneficial effect of a soyabean-substituted diet with hypercholesterolaemia only for short-term interventions 12,15 . The present study participants achieved a significant reduction of TC and LDL-C in an extended design of 3 months.…”