Effects of a single intranasal dose of modified-live bovine respiratory syncytial virus vaccine on resistance to subsequent viral challenge in calves

Woolums, Amelia R.; Brown, Corrie C.; Brown, James R.; Cole, D.J.W.; Scott, Melissa A.; Williams, Shamita M.; Miao, Congrong

doi:10.2460/ajvr.2004.65.363

Cited by 25 publications

(15 citation statements)

References 25 publications

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“…The intramuscular route is a classical way of injection for inactivated vaccines. As it is true for live virus, intranasal vaccination with live-BRSV or modified-live-BRSV vaccine has been shown to be more efficacious in reducing viral shedding than intramuscular administration in young calves [40,41]. Moreover, a single intranasal vaccination has previously been shown to prime calves in the face of maternal antibodies [41].…”

Section: Discussionmentioning

confidence: 99%

“…As it is true for live virus, intranasal vaccination with live-BRSV or modified-live-BRSV vaccine has been shown to be more efficacious in reducing viral shedding than intramuscular administration in young calves [40,41]. Moreover, a single intranasal vaccination has previously been shown to prime calves in the face of maternal antibodies [41]. Commercially available modified-live-BRSV vaccines that were formulated and licensed for parenteral use were shown to induce partial protection when administered intranasally [42].…”

Section: Discussionmentioning

confidence: 99%

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A new subunit vaccine based on nucleoprotein nanoparticles confers partial clinical and virological protection in calves against bovine respiratory syncytial virus

Riffault¹,

Meyer

Deplanche

et al. 2010

Vaccine

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Human and bovine respiratory syncytial viruses (HRSV and BRSV) are two closely related, worldwide prevalent viruses that are the leading cause of severe airway disease in children and calves, respectively. Efficacy of commercial bovine vaccines needs improvement and no human vaccine is licensed yet. We reported that nasal vaccination with the HRSV nucleoprotein produced as recombinant ring-shaped nanoparticles (N(SRS)) protects mice against a viral challenge with HRSV. The aim of this work was to evaluate this new vaccine that uses a conserved viral antigen, in calves, natural hosts for BRSV. Calves, free of colostral or natural anti-BRSV antibodies, were vaccinated with N(SRS) either intramuscularly, or both intramuscularly and intranasally using Montanide ISA71 and IMS4132 as adjuvants and challenged with BRSV. All vaccinated calves developed anti-N antibodies in blood and nasal secretions and N-specific cellular immunity in local lymph nodes. Clinical monitoring post-challenge demonstrated moderate respiratory pathology with local lung tissue consolidations for the non-vaccinated calves that were significantly reduced in the vaccinated calves. Vaccinated calves had lower viral loads than the non-vaccinated control calves. Thus N(SRS) vaccination in calves provided cross-protective immunity against BRSV infection without adverse inflammatory reaction.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A new subunit vaccine based on nucleoprotein nanoparticles confers partial clinical and virological protection in calves against bovine respiratory syncytial virus

Riffault¹,

Meyer

Deplanche

et al. 2010

Vaccine

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“…In fact, Kimman and colleagues demonstrated in the late 1980s that intranasal inoculation of tissue culture attenuated bRSV to passively immune calves primed for mucosal memory and an anamnestic IgA response subsequent to challenge [70]. More recent studies with culture-attenuated bRSV confirmed this observation [71] and demonstrated that pulmonary inflammation was decreased in vaccinated calves as determined by decreased expression of tumor necrosis factor-α mRNA [72]. Furthermore, although the vaccinated calves in this experiment had decreased clinical signs of disease compared with mock vaccinated calves, this difference was not related to a Th1 bias, as determined by increased expression of interferon-γ mRNA relative to interleukin-4 mRNA in lungs, bronchioalveolar lavage fluid cells or tracheobroncheal lymph nodes of vaccinated calves [72].…”

Section: Live-attenuated Mucosal Brsv Vaccinesmentioning

confidence: 82%

Immunization strategies for the prevention of pneumovirus infections

Bennett

Ellis

Bonville

et al. 2007

Expert Review of Vaccines

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Pneumoviruses, which are viruses of the family Paramyxoviridae, subfamily Pneumovirinae, are pathogens that infect the respiratory tract of their host species. The human pneumovirus pathogen, human respiratory syncytial virus (RSV), has counterparts that infect cows (bovine RSV), sheep (ovine RSV), goats (caprine RSV) and rodents (pneumonia virus of mice). Each pneumovirus is host specific and results in a spectrum of disease, ranging from mild upper-respiratory illness to severe bronchiolitis and pneumonia with significant morbidity and mortality. Given the public health burden caused by human RSV and the concomitant agricultural impact of bovine RSV, these two viruses are considered as prime targets for the development of safe and effective vaccines. In this review, we describe the strategies used to develop vaccines against human and bovine RSV and introduce the pneumonia virus mouse model as a novel and invaluable tool for preclinical studies and new vaccine strategies.

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“…While the intranasal route for vaccinating 1 week and older calves has the benefi t of inducing rapid immunity that can circumvent potential interference from circulating maternal antibodies (Kimman et al, 1989 ;Bryson et al, 1999 ;Woolums et al, 2004 ;Vangeel et al, 2007Vangeel et al, , 2009, the effectiveness of newborn calf vaccination needs to be established.…”

Section: Vaccinating Calvesmentioning

confidence: 99%

Management of Dairy Calves from Birth to Weaning

McGuirk

2011

Dairy Production Medicine

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Calves represent the future of the dairy and, as such, management during the critical stage from birth to weaning is critical to the development, health, productivity, and profi tability of the future replacement heifers. The perinatal period is one of the most vulnerable times in the life of the calf, and attention to the details of calving and calf viability immediately after birth can prevent the losses commonly encountered in the fi rst 48 h of life. New concepts in colostrum management not only reinforce the importance of colostral immune factors on calf health but also emphasize its longer term impact on intestinal, ruminal, and metabolic development as well as the impact on endocrine status, growth, productivity, and survival. Nutritional management concepts have changed and are now appropriately focused on targeted growth with components and delivery systems that promote welfare, performance, and future production. Whether young calves are housed in individual or group pens, important principles of housing management can be applied to insure the health and welfare of preweaned calves. Routine health maintenance practices, preventive health screening, and effective treatment protocols should be strategically integrated into the management of young calves to optimize health, minimize stress, cost, and the possibility of doing harm.

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Effects of a single intranasal dose of modified-live bovine respiratory syncytial virus vaccine on resistance to subsequent viral challenge in calves

Abstract: An intranasal dose of modified-live BRSV vaccine can protect calves against virulent BRSV challenge 1 month later.

Cited by 25 publications

References 25 publications

A new subunit vaccine based on nucleoprotein nanoparticles confers partial clinical and virological protection in calves against bovine respiratory syncytial virus

A new subunit vaccine based on nucleoprotein nanoparticles confers partial clinical and virological protection in calves against bovine respiratory syncytial virus

Immunization strategies for the prevention of pneumovirus infections

Management of Dairy Calves from Birth to Weaning

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