Effects of a Single Dose of Exenatide on Appetite, Gut Hormones, and Glucose Homeostasis in Adults with Prader-Willi Syndrome

Abstract

Our pilot study demonstrates that exenatide is well tolerated in PWS patients. It increases satiety independently of measured appetite hormones, exerting glucose lowering, and insulinotropic effects similarly in PWS and OBESE patients. Larger prospective studies should investigate whether chronic exenatide administration will reduce hyperphagia and overweight in PWS patients without side effects.

The glucagon-like peptide-1 analog liraglutide suppresses ghrelin and controls diabetes in a patient with Prader-Willi syndrome

“…On the basis of the data in the previous reports [21][22][23][24][25], it is conceivable that postprandial elevation of plasma active GLP-1 concentration suppresses ghrelin secretion via the vagal nerve system. Nevertheless, a pharmacological amount of GLP-1 was needed to lower plasma ghrelin in the patient with PWS.…”

Glucagon like pepetide-1 agonist in a patient with prader-willi syndrome: a Sri Lankan experience

“…A small placebo controlled cross over study done on the effects of a single dose of exenatide on appetite, gut hormones and glucose homeostasis in adult patients with PWS and obese controls, demonstrated increase in satiety independent of measured appetite hormones, lower glucose levels and insulinotropic effect in both groups (12). Ghrelin levels and energy expenditure were not affected and gastrointestinal side effects were common among the obese patients but absent among patients with PWS.…”

“…This is due to its potential effects on ghrelin suppression, central appetite suppression and increase in the energy expenditure and stimulation of insulin secretion (12).…”

An Update on Prader-Willi Syndrome with Diabetes Mellitus

“…Also, PWS diabetic patients showed the difference that it has no gastrointestinal side effects compared with non-PWS T2DM patients. It may suggest that there is not only high tolerance of nausea, pain, but also altered GLP-1 signaling in brain 14) . Several recent PWS case reports suggest that the effect of GLP-1 RA on weight loss may be related to reduction of ghrelin, leading to an improvement of hyperphagia, body mass index, and visceral fat 15) .…”