Effects of a simple prototype respiratory muscle trainer on respiratory muscle strength, quality of life and dyspnea, and oxidative stress in COPD patients: a preliminary study

Leelarungrayub, Jirakrit; Pinkaew, Decha; Puntumetakul, Rungthip; Klaphajone, Jakkrit

doi:10.2147/copd.s131062

Cited by 24 publications

(41 citation statements)

References 55 publications

(69 reference statements)

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“…Although a previous study has confirmed that exercise does regulate inflammation in COPD airways and lung tissues (56), the markers of inflammation were not investigated and therefore it is not able to be concluded. In addition, although some studies have demonstrated that aerobic exercise reversed the airway remodeling in asthmatic mice (57,58), the results of the present study suggested that the benefits of exercise on COPD were more significant in terms of respiratory muscle strength, exercise capacity and exercise-induced dyspnea, which is consistent with the conclusions of other previous studies (59)(60)(61).…”

Section: Discussionsupporting

confidence: 91%

Muscle metabolomics analysis reveals potential biomarkers of exercise‑dependent improvement of the diaphragm function in chronic obstructive pulmonary disease

et al. 2020

Int J Mol Med

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decreased diaphragm function is a crucial factor leading to reduced ventilatory efficiency and worsening of quality of life in chronic obstructive pulmonary disease (cOPd). Exercise training has been demonstrated to effectively improve the function of the diaphragm. However, the mechanism of this process has not been identified. The emergence of metabolomics has allowed the exploration of new ideas. The present study aimed to analyze the potential biomarkers of exercise-dependent enhancement of diaphragm function in COPD using metabolomics. Sprague Dawley rats were divided into three groups: COPD + exercise group (CEG); COPD model group (CMG); and control group (CG). The first two groups were exposed to cigarette smoke for 16 weeks to establish a COPD model. Then, the rats in the CEG underwent aerobic exercise training for 9 weeks. Following confirmation that exercise effectively improved the diaphragm function, a gas chromatography tandem time-of-flight mass spectrometry analysis system was used to detect the differential metabolites and associated pathways in the diaphragm muscles of the different groups. Following exercise intervention, the pulmonary function and diaphragm contractility of the CEG rats were significantly improved compared with those of the CMG rats. A total of 36 different metabolites were identified in the comparison between the CMG and the CG. Pathway enrichment analysis indicated that these different metabolites were involved in 17 pathways. A total of 29 different metabolites were identified in the comparison between the CMG and the CEG, which are involved in 14 pathways. Candidate biomarkers were selected, and the pathways analysis of these metabolites demonstrated that 2 types of metabolic pathways, the nicotinic acid and nicotinamide metabolism and arginine and proline metabolism pathways, were associated with exercise-induced pulmonary rehabilitation.

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Section: Discussionsupporting

confidence: 91%

Muscle metabolomics analysis reveals potential biomarkers of exercise‑dependent improvement of the diaphragm function in chronic obstructive pulmonary disease

et al. 2020

Int J Mol Med

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“…The results of the present study showed that there was a significant change in pulmonary function test parameters that may indicate an effect on airflow limitation. This was supported by Leelarungrayub et al 23 who studied the effect of a simple prototype device in moderate to severe COPD patients for 6 weeks. The device consisted of six resistors of different diameters (2–7 mm).…”

Section: Discussionmentioning

confidence: 71%

Comparative study of two different respiratory training protocols in elderly patients with chronic obstructive pulmonary disease

Mehani¹

2017

CIA

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AimThe aim of the present study was to compare threshold inspiratory muscle training (IMT) and expiratory muscle training (EMT) in elderly male patients with moderate degree of COPD.Materials and methodsForty male patients with moderate degree of COPD were recruited for this study. They were randomly divided into two groups: the IMT group who received inspiratory training with an intensity ranging from 15% to 60% of their maximal inspiratory pressure, and the EMT group who received expiratory training with an equal intensity which was adjusted according to the maximal expiratory pressure. Both groups received training three times per week for 2 months, in addition to their prescribed medications.ResultsBoth IMT and EMT groups showed a significant improvement in forced vital capacity, forced expiratory volume in the first second, forced expiratory volume in the first second% from the predicted values, and forced vital capacity% from the predicted value, with no difference between the groups. Both types of training resulted in a significant improvement in blood gases (SaO2%, PaO2, PaCO2, and HCO3), with the inspiratory muscle group showing the best results. Both groups showed a significant improvement in the 6-min walking distance: an increase of about 25% in the inspiratory muscle group and about 2.5% in the expiratory muscle group.ConclusionBoth IMT and EMT must be implemented in pulmonary rehabilitation programs in order to achieve improvements in pulmonary function test, respiratory muscle strength, blood oxygenation, and 6-min walking distance.

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“…Of these, 25 studies (n ¼ 631 subjects) included subjects with respiratory muscle weakness. [17][18][19][22][23][24][25][26][27][28][31][32][33][34]37,38,40,41,43,[45][46][47][48][49]52 Various loads for IMT were 15% of P Imax , 42,46,48 30% of P Imax , 17,28,31,33,38,40,43,51 load progression of 5-35% of P Imax , 23,24 load progression up to 40-50% of P Imax , 21,39,53 load progression up to 60% of P Imax , 18,20,22,[24][25][26][27][28]30,…”

Section: Description Of the Studiesmentioning

confidence: 99%

“…36 Belman et al 19 and Oh 35 used PFLEX equipment, and the load used for IMT was not clear. Leelarungrayub et al 32 used Portex equipment, and load/resistance was set by the tube diameter (ie, 6 mm, 4 mm, and 2 mm) (can be seen in supplementary materials at http://www. rcjournal.com).…”

Section: Description Of the Studiesmentioning

confidence: 99%

“…Maximum Inspiratory Pressure. Of the 39 papers included that conducted isolated IMT, 36 studies [17][18][19][20][21][22][23][24][25][26][27][29][30][31][32][33][34][36][37][38][39][40][41][43][44][45][46][47][48][49][50][51][52][53][54][55] assessed P Imax (n ¼ 889 subjects). Significant improvement occurred in P Imax when IMT was compared to the control groups (10.64 cm H 2 O, 95% CI 7.61-13.66, I 2 : 46%) ( Fig.…”

Section: Effects Of Interventionsmentioning

confidence: 99%

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Inspiratory Muscle Training in COPD

et al. 2020

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BACKGROUND: The benefits of inspiratory muscle training (IMT) for patients with COPD are documented in the literature, but its isolated effect or association with other interventions, the best training methods, and what type of patient benefits the most are not clear. We sought to assess the effects of IMT on respiratory muscle strength, pulmonary function, dyspnea, functional capacity, and quality of life for subjects with COPD, considering IMT isolated or association with other interventions, presence of inspiratory muscle weakness, training load, and intervention time. METHODS: We searched the MEDLINE, EMBASE, PEDro, Cochrane CENTRAL, and LILACS databases in June 2018. We also performed a manual search of references in the studies found in the database search and included in this analysis. We included randomized controlled trials that investigated the abovementioned outcomes and assessed IMT, either isolated or associated with other interventions, in comparison with a control group, placebo, or other interventions, in subjects with COPD. We used the GRADE approach to evaluate the quality of the evidence. RESULTS: Of 1,230 search results, 48 were included (N 5 1,996 subjects). Isolated IMT increased P Imax (10.64 cm H 2 O, 95% CI 7.61-13.66), distance walked in 6-min-walk test (34.28 m; 95% CI 29.43-39.14), and FEV 1 (0.08, 95% CI 0.02-0.13). However, there was no improvement in dyspnea and quality of life. The presence of inspiratory muscle weakness did not change the results; higher loads (60-80% of P Imax) promoted a greater improvement in these outcomes, and a shorter intervention time (4 weeks) improved P Imax , but longer intervention times (6-8 weeks) are required to improve functional capacity. IMT associated with other interventions only showed an increase in P Imax (8.44 cm H 2 O; 95% CI 4.98-11.91), and the presence of inspiratory muscle weakness did not change this result. CONCLUSIONS: Isolated IMT improved inspiratory muscle strength, functional capacity, and pulmonary function, without changing dyspnea and quality of life. Associated IMT only increased inspiratory muscle strength. These results indicate that isolated IMT can be considered as an adjuvant intervention in patients with COPD.

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Effects of a simple prototype respiratory muscle trainer on respiratory muscle strength, quality of life and dyspnea, and oxidative stress in COPD patients: a preliminary study

Cited by 24 publications

References 55 publications

Muscle metabolomics analysis reveals potential biomarkers of exercise‑dependent improvement of the diaphragm function in chronic obstructive pulmonary disease

Muscle metabolomics analysis reveals potential biomarkers of exercise‑dependent improvement of the diaphragm function in chronic obstructive pulmonary disease

Comparative study of two different respiratory training protocols in elderly patients with chronic obstructive pulmonary disease

Inspiratory Muscle Training in COPD

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