Effects of a short term supplementation of a fermented papaya preparation on biomarkers of diabetes mellitus in a randomized Mauritian population

Somanah, Jhoti; Aruoma, Okezie I.; Gunness, Teeluck K.; Kowelssur, Sudhir; Dambala, Venkatesh; Murad, Fatima; Googoolye, Kreshna; Daus, Diana; Indelicato, Joseph; Bourdon, Emmanuel; Bahorun, Theeshan

doi:10.1016/j.ypmed.2012.01.014

Cited by 32 publications

(51 citation statements)

References 18 publications

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“…Employing two highly sensitive luminol-dependant chemiluminescence assays, the authors demonstrated that under pathological conditions FPP could easily dissolve in saliva or red blood cells to augment their antioxidant capacities-possibly by increasing the solubility and availability of polyphenols present in the FPP. This theory was also believed to be observed in a study conducted by our group [30]. Interestingly, one previous study has shown that consumption of FPP indeed leads to an increased rate of salivary secretions that is high in IgA, phase II enzymes and SOD gene expression [31].…”

Section: Examining the Anti-cariogenic Potential Of Fppsupporting

confidence: 62%

Discovering the health promoting potential of fermented papaya preparation- its future perspectives for the dietary management of oxidative stress during diabetes

Somanah-Bhugowandeen¹,

Putteeraj²,

Aruoma³

et al. 2018

Preprint

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The simplistic morphological characteristics of the Carica papaya, papaya or ‘pawpaw’ should not be the cause for underestimating its potential as a nutraceutical. The market for papaya has been expanding at a staggering rate, partly due to its applicability as a biofortified product, but mostly for its phytochemical properties and traditional health benefits. Recent characterization studies have showed that the entirety of papaya or using a formulation of fermented papaya promotion (FPP) displays effective free radical scavenging abilities, thought to be influenced by its phenolic, carotenoids, flavonoid or amino acid profile. Aiming at reducing the impact of free radical-induced oxidative damage in the human system, the antioxidant properties of FPP have been found to potently target a broad spectrum of diseases ranging from neurological impairments such as senile dementia to systemic diseases, to its interference at the cellular level and support of normal biological ageing processes. FPP has thus been extensively investigated for its ability to exert cellular protective effects and reduce oxidative stress via mitigation of genetic damage, lipid peroxidation and enzymatic inactivation in diseases. Oxidative stress reduction strategies using FPP and its holistic approach in disease prevention and management, with a focus on diabetes, cancer and cognitive health, contributes unequivocally to wellness in an aging population.

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Section: Examining the Anti-cariogenic Potential Of Fppsupporting

confidence: 62%

Discovering the health promoting potential of fermented papaya preparation- its future perspectives for the dietary management of oxidative stress during diabetes

Somanah-Bhugowandeen¹,

Putteeraj²,

Aruoma³

et al. 2018

Preprint

Self Cite

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“…While this clinical study does not support the use of a polyherbal formulation to support IFG over a 12 week period, there is the possibility that the polyherbal formulation may improve IFG levels over a longer period such as 24 weeks when combined with lifestyle changes and such a study would need to be adequately powered. As such, the impact of pycnogenol, papain and Aloe vera on fasting insulin levels warrants further investigation, given that research suggests that these herbal medicines could be important in the management of pre-T2D [26][27][28][29].…”

Section: Discussionmentioning

confidence: 99%

A Double-Blind Randomized Placebo-Controlled Study Assessing the Safety, Tolerability and Efficacy of a Herbal Medicine Containing Pycnogenol Combined with Papain and Aloe vera in the Prevention and Management of Pre-Diabetes

et al. 2020

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Background: Herbal medicines present attractive options to patients with chronic diseases. Undertaking clinical studies with patients presenting with symptomless pre-T2D can lead to significant limitations. Methods: A 12-week randomized double-blind placebo-controlled clinical study was conducted that investigated the safety and efficacy of an herbal formulation administered orally for the treatment of pre-type 2 diabetes (pre-T2D). Results: A numerically greater proportion of subjects in the interventional arm had impaired fasting glucose (IFG) at week 12 compared to the control arm (71.0% vs. 69.0%, p = 0.75). Fewer participants had impaired glucose tolerance (IGT) at 12 weeks in the intervention arm compared to the control arm (unadjusted 58.3% vs. 66.7%, p = 0.65; adjusting for baseline IGT, p = 0.266). In a subgroup analysis, subjects with a baseline fasting plasma glucose (FPG) level in the range of 6.1–6.9 mmol/L demonstrated a non-significant lower proportion of IFG at week 12 in the intervention arm compared to the control arm (60.0% vs. 41.7% p = 0.343). Total blood cholesterol and triglyceride levels remained unchanged from baseline to week 12 in both treatment groups. Conclusions: This study suggests that a polyherbal medicine was not effective for reducing the metabolic markers associated with pre-T2D over a 12-week period. Therefore, larger studies with well-defined endpoints and of longer duration are warranted.

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“…Ingredients of the papaya fruit and the processed fruit have been associated with a beneficial impact on digestion or diseases (Aruoma et al, 2010;Forstner, 1971;Ghoti et al, 2011;Marotta et al, 2011;Scolapio et al, 1999;Somanah et al, 2012). The fruit is considered as a traditional remedy for gastrointestinal functional disorders in countries with papaya plants.…”

Section: Biological Activitiesmentioning

confidence: 99%

Papaya: A gifted nutraceutical plant - a critical review of recent human health research

Karunamoorthi¹,

Kim²,

Jegajeevanram³

et al. 2014

TANG [HUMANITAS MEDICINE]

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The plant kingdom is considered to be a repository of modern medicine, attributable to their rich source of bio-active molecules and secondary metabolites. It is indeed the Nutraceuticals that enhance immunity and ensure a healthier life because of their prophylactic and therapeutic values. Over centuries, papaya [Caricaceae; (Carica papaya Linn.)] is a renowned nutritious and medicinal plant. Each part of the papaya like root, stem, leaf, flower, fruit, seed, rinds, and latex has its own nutraceutical properties. It serves as food, cooking aid, and Ethnomedicine to prevent and treat wide-range of diseases and disorders. It has also been traditionally used as appetite enhancer, meat tenderizer, purgative, medicinal acne, abortifacient and vermifuge. Over decades, a series of scientific attempts were made to authenticate the nutraceutical properties of papaya. These studies validated that the papaya has antiplasmodial, antitrichochramal, antitrichomonal, antidengue, and anti-cancer activities. They have also exhibited that papaya possesses antiseptic, antiparasitic, anti-inflammatory, antidiabetic, and contraceptive features, and it helps in the management of sickle-cell anaemia, HIV, heart diseases and digestional disorders too. Nevertheless, the responsible bio-active molecules and their mode of actions remain indistinct and imprecise, and this calls for further pharmacological and clinical research on them. Conclusively, papaya is one of the naturally gifted plants; though its nutraceutical properties as a food or as a quasi-drug are poorly understood or undervalued by people. Accordingly, this scrutiny, demand for instigation of public health awareness campaigns to promote papaya consumption, so that the society shall acquire optimal benefits of papaya and in turn prevent and alleviate various diseases and illness.

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Effects of a short term supplementation of a fermented papaya preparation on biomarkers of diabetes mellitus in a randomized Mauritian population

Cited by 32 publications

References 18 publications

Discovering the health promoting potential of fermented papaya preparation- its future perspectives for the dietary management of oxidative stress during diabetes

Discovering the health promoting potential of fermented papaya preparation- its future perspectives for the dietary management of oxidative stress during diabetes

A Double-Blind Randomized Placebo-Controlled Study Assessing the Safety, Tolerability and Efficacy of a Herbal Medicine Containing Pycnogenol Combined with Papain and Aloe vera in the Prevention and Management of Pre-Diabetes

Papaya: A gifted nutraceutical plant - a critical review of recent human health research

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