Effects of a Short Course of Oral Prednisolone in Patients with Bladder Pain Syndrome with Fluctuating, Worsening Pain despite Low-Dose Triple Therapy

Jeong, Hee Jong

doi:10.5213/inj.2012.16.4.175

Cited by 13 publications

(17 citation statements)

References 16 publications

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“…The importance of this question was highlighted recently in a small longitudinal study of flares, in which some participants reported flares lasting only a few minutes [8] – a shorter duration of flare than had been documented previously in the literature [5, 7, 10] and one that we have since found to be fairly common (30% of female participants reported experiencing minutes-long flares in response to a short survey [9]). This unexpected finding raised the possibility of other lesser-recognized aspects of flares.…”

Section: Introductionmentioning

confidence: 82%

Urological chronic pelvic pain syndrome flares and their impact: qualitative analysis in the MAPP network

Sutcliffe¹,

Bradley

Clemens

et al. 2015

Int Urogynecol J

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Introduction Although in-depth qualitative information is critical for understanding patients’ symptom experiences and for developing patient-centered outcome measures, only one previous qualitative study has assessed urologic chronic pelvic pain syndrome (UCPPS) symptom exacerbations (“flares”). Methods We conducted eight focus groups of female UCPPS (interstitial cystitis/bladder pain syndrome) patients at four sites of the MAPP Research Network (n=57, mean=7/group) to explore the full spectrum of flares and their impact on patients’ lives. Results Flare experiences were common and varied widely in terms of UCPPS symptoms involved, concurrent non-pelvic symptoms (e.g., diarrhea), symptom intensity (mild to severe), duration (minutes to years), and frequency (daily to

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Section: Introductionmentioning

confidence: 82%

Urological chronic pelvic pain syndrome flares and their impact: qualitative analysis in the MAPP network

Sutcliffe¹,

Bradley

Clemens

et al. 2015

Int Urogynecol J

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“…A well-known anti-inflammatory drug, such as prednisolone, is widely used in treating psoriasis, allergic conditions, respiratory disorders and ulcerative colitis. Several studies have shown its effectiveness in improving pain in rheumatoid arthritis, chronic bladder syndrome and athralgia [9][10][11][12][13][14]. However, the administration of a higher dose of prednisolone or administration for a long period may lead to various adverse effects [15].…”

Section: Introductionmentioning

confidence: 99%

Preemptive Effects of Administration of Tualang Honey on Inflammatory Responses in Adult Male Rats

Ismail

Hussin

Mohamed

et al. 2017

J. Pharm. Nutr. Sci.

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Background: Honey was reported to reduce pain and inflammation from burn wound. To date, no study has compared between the effects of Tualang honey and prednisolone on inflammatory responses in rats. This study has examined the effects of Tualang honey and prednisolone on inflammatory pain and its associated inflammatory responses secondary to formalin injection. Methods: Twenty-one Sprague-Dawley male rats were randomised into control, Tualang honey (1.2 g/kg) or prednisolone (10 mg/kg) groups. Formalin test was conducted and the rats were sacrificed at four-hours post-formalin injection. Serum was collected for measurement of leukocyte counts and interleukins level. All data were analysed using one-way ANOVA with post-hoc Scheffe's or Dunnet's C test. Significance level was taken as less than 0.05. Results: Tualang honey and prednisolone groups had significantly reduced pain behaviour and paw edema compared to control group. Tualang honey group demonstrated a significant increase in blood neutrophil count while prednisolone group had significant reduction in blood lymphocyte and monocyte counts compared to control group. Only interleukin-6 level was significantly reduced in honey group. Both interleukin-6 and-8 levels were significantly reduced in prednisolone group. Conclusions: Tualang honey is comparable to prednisolone in modulating the inflammatory pain responses in rats; however, with regards to local and systemic inflammatory responses, it has differential effects compared to prednisolone.

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“…In our previous small, longitudinal study designed to quantify symptom changes during flares, particularly those lasting >1 day , we found unexpectedly that some participants reported flares lasting only a few minutes. As we are not aware of any references to flares of this short duration in the published literature (only flares lasting at least a few hours to several days or weeks have been referenced ), we conducted an exploratory study at two sites of the ongoing Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Epidemiology and Phenotyping study to examine the full range of urological CPPS flares, and to determine which of these flares warrant further study based on their associated healthcare utilization and, more importantly, degree of bother to participants. This type of descriptive information that draws upon patient experiences is critical to inform future studies on flare prevention, treatment and management.…”

Section: Introductionmentioning

confidence: 99%

Urological chronic pelvic pain syndrome symptom flares: characterisation of the full range of flares at two sites in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network

et al. 2014

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Objectives To describe the full spectrum of symptom exacerbations defined by interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome patients as flares, and to investigate their associated health-care utilization and bother at two sites of the Trans-Multidisciplinary Approaches to the Study of Chronic Pelvic Pain (Trans-MAPP) Epidemiology and Phenotyping study. Patients and methods Participants completed a flare survey that asked them: 1) whether they had ever had flares (“symptoms that are much worse than usual”) that lasted <1 hr, >1 hr and <1 day, and >1 day; and 2) for each duration of flare, to report their: a) average length and frequency; b) typical levels of urologic and pelvic pain symptoms; and c) levels of health-care utilization and bother. We compared participants' responses to their non-flare Trans-MAPP values and across flares using generalized linear mixed models. Results Seventy six of 85 participants (89.4%) completed the flare survey, 72 of whom reported having flares (94.7%). Flares varied widely in terms of their duration (seconds to months), frequency (several times per day to once per year or less), and intensity and type of symptoms (e.g., pelvic pain versus urologic symptoms). Flares of all duration were associated with greater pelvic pain, urologic symptoms, disruption to participants' activities, and bother, with increasing severity of each of these factors as the duration of flares increased. Days-long flares were also associated with greater health-care utilization. In addition to duration, symptoms (pelvic pain, in particular) were also significant determinants of flare-related bother. Conclusions Our findings suggest that flares are common and associated with greater symptoms, health-care utilization, disruption, and bother. Our findings also inform the characteristics of flares most bothersome to patients (i.e., increased pelvic pain and duration), and thus of greatest importance to consider in future research on flare prevention and treatment.

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Effects of a Short Course of Oral Prednisolone in Patients with Bladder Pain Syndrome with Fluctuating, Worsening Pain despite Low-Dose Triple Therapy

Cited by 13 publications

References 16 publications

Urological chronic pelvic pain syndrome flares and their impact: qualitative analysis in the MAPP network

Urological chronic pelvic pain syndrome flares and their impact: qualitative analysis in the MAPP network

Preemptive Effects of Administration of Tualang Honey on Inflammatory Responses in Adult Male Rats

Urological chronic pelvic pain syndrome symptom flares: characterisation of the full range of flares at two sites in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network

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