Effects of a selanylimidazopyridine on the acute restraint stress-induced depressive- and anxiety-like behaviors and biological changes in mice

Domingues, Micaela; Casaril, Angela Maria; Birmann, Paloma T.; Bampi, Suely Ribeiro; Lourenço, Darling de Andrade; Vieira, Beatriz; Dapper, Luiz H.; Lenardão, Eder J.; Sonego, Mariana Souza; Collares, Tiago; Seixas, Fabiana Kömmling; Brüning, César Augusto; Savegnago, Lucielli

doi:10.1016/j.bbr.2019.03.021

Cited by 43 publications

(32 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Restraint stress is one of the most widely used stress paradigm in rodents. For acute restraint stress (ARS), some studies have reported decreased BDNF mRNA and protein levels in the prefrontal cortex and hippocampus but increased BDNF expression in the amygdala of rodents [26,[39][40][41][42]. However, other studies have also shown the opposite trend in Bdnf mRNA levels in these brain areas following acute stress [43,44].…”

Section: Restraint Stressmentioning

confidence: 99%

The Relationships Between Stress, Mental Disorders, and Epigenetic Regulation of BDNF

Zhang

Wang

Sun

2020

IJMS

View full text Add to dashboard Cite

Brain-derived neurotrophic factor (BDNF), a critical member of the neurotrophic family, plays an important role in multiple stress-related mental disorders. Although alterations in BDNF in multiple brain regions of individuals experiencing stress have been demonstrated in previous studies, it appears that a set of elements are involved in the complex regulation. In this review, we summarize the specific brain regions with altered BDNF expression during stress exposure. How various environmental factors, including both physical and psychological stress, affect the expression of BDNF in specific brain regions are further summarized. Moreover, epigenetic regulation of BDNF, including DNA methylation, histone modification, and noncoding RNA, in response to diverse types of stress, as well as sex differences in the sensitivity of BDNF to the stress response, is also summarized. Clarification of the underlying role of BDNF in the stress process will promote our understanding of the pathology of stress-linked mental disorders and provide a potent target for the future treatment of stress-related illness.

show abstract

Section: Restraint Stressmentioning

confidence: 99%

The Relationships Between Stress, Mental Disorders, and Epigenetic Regulation of BDNF

Zhang

Wang

Sun

2020

IJMS

View full text Add to dashboard Cite

show abstract

“…As ARS causes HPA axis dysregulation, oxidative damage, glucose metabolism dysfunction and neuroinflammation, which causes depression‐/anxiety‐like behaviours in mice. [ 9,10,21 ] The well‐known open field, forced swimming, tail suspension and tail suspension test are used to assess the depression‐like behaviour of mice, and the marble burying and elevated plus maze tests are used to evaluate their anxiety‐like behaviour. [ 10,22–24 ] By exposing mice to ARS and conducting the forced swimming test and tail suspension test, we found that immobility duration and grooming time increased, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…[ 9,10,21 ] The well‐known open field, forced swimming, tail suspension and tail suspension test are used to assess the depression‐like behaviour of mice, and the marble burying and elevated plus maze tests are used to evaluate their anxiety‐like behaviour. [ 10,22–24 ] By exposing mice to ARS and conducting the forced swimming test and tail suspension test, we found that immobility duration and grooming time increased, respectively. The mice subjected to ARS treatment showed increased number of buried marbles in the marble burying test and spend less time on the open arms in the elevated plus maze test.…”

Section: Discussionmentioning

confidence: 99%

“…[ 6–8 ] Acute restraint stress (ARS), which causes depression‐ and anxiety‐like behaviours in experimental animals, induces an increase in proinflammatory cytokines, serum corticosterone and reactive oxygen/nitrogen species generation in the prefrontal cortex and hippocampus. [ 9,10 ] Neuroinflammation also plays key functions in neuropathic pain‐associated mental disorders. The Nod‐like receptor protein‐1 inflammasome, which regulates the production of proinflammatory cytokines, is significantly increased in the hippocampus of rats with neuropathic pain.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

e5NT inhibitor protects acute restraint stress-induced depression by regulating nucleoside release in mice

Liu

Zhu

Zhou

et al. 2020

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

Objectives To determine whether ecto-5 0-nucleotidase (e5NT) contributes to the release of adenosine and uridine and whether is establishes the role of e5NT in acute restraint stress-induced depression and anxiety-like behaviours in mice. Methods Acute restraint stress was induced to detect the level of nucleoside in the hippocampus. Mouse hippocampal brain proteins were isolated and subjected to Western blotting (WB) experiments to examine the protein expression levels of proteins that affect nucleoside release. Adenosine 5 0-(a,b-methylene) diphosphate (APCP), an e5NT inhibitor, was intraventricularly injected to investigate the regulatory effect of e5NT on nucleoside levels and behavioural changes caused by acute restraint stress in mice. Key findings Acute restraint stress increased the level of extracellular adenosine and uridine levels in the hippocampus of mice and significantly increased the expression of extracellular nucleoside-metabolizing enzymes were significantly increased. By administering APCP, the increase in adenosine and uridine levels caused by acute restraint stress could be suppressed. APCP inhibited behavioural changes, which were induced by acute restraint stress. Conclusions These data suggest that acute restraint stress may alter extracellular adenosine and uridine levels content in the hippocampus of mice via e5NT, and thus, the inhibition of e5NT may improve the anxiety behaviour in mice. Therefore, e5NT may therefore be a potential therapeutic target for the treatment of anxiety in mice.

show abstract

“…A 10% sucrose solution was sprinkled on the dorsal coat of mice while they were in their home cages and mice were recorded for the duration of 5 min. The period of grooming activity behavior including nose/ face cleaning, head washing, and body grooming was seen by a person blinded to the experiment [32].…”

Section: Splash Testmentioning

confidence: 99%

Trigonelline through the Attenuation of Oxidative Stress Exerts Antidepressant- and Anxiolytic-Like Effects in a Mouse Model of Maternal Separation Stress

et al. 2019

View full text Add to dashboard Cite

Depression and anxiety are common psychiatric disorders accounting for social and economic burdens. Previous studies have shown that oxidative stress and oxidant/antioxidant imbalance are involved in the pathophysiology of psychiatric disorders. Experiencing early-life adversities (like maternal separation [MS] stress) provoked psychiatric disorders. Trigonelline (TRG) is a pyridine alkaloid that has various pharmacological effects including hypoglycemic, neuroprotective and memory-improving properties. To investigate the antidepressant-and anxiolytic-like effects of TRG focusing oxidative stress, we applied the MS paradigm to male mice at postnatal day (PND) 2-14 (3 h daily, 9-12 a.m.) and investigated the behaviors at PND 45-47. Using valid behavioral tests including a forced swimming test (FST), splash test, open field test (OFT) and elevated plus maze (EPM), we investigated behavioral modifications. Additionally, we examined the effects of MS and TRG treatment on the level of malondialdehyde (MDA), nitric oxide (NO) and also antioxidant capacity in the brain and serum. Our results showed that MS provoked depressive-and anxiety-like behaviors in the FST, OFT, EPM and splash test, which are associated with an increase in MDA and NO levels as well as a decrease in antioxidant capacity in the brain and serum samples. Findings determined that TRG significantly reversed the negative effects of MS on behavior that is accompanied by a decrease in MDA and NO as well as an increase in antioxidant capacity. Findings of the present study showed that beneficial effects of TRG may be, at least partially, mediated via the reduction of oxidative stress and an increase of antioxidant capacity.

show abstract

Effects of a selanylimidazopyridine on the acute restraint stress-induced depressive- and anxiety-like behaviors and biological changes in mice

Cited by 43 publications

References 41 publications

The Relationships Between Stress, Mental Disorders, and Epigenetic Regulation of BDNF

The Relationships Between Stress, Mental Disorders, and Epigenetic Regulation of BDNF

e5NT inhibitor protects acute restraint stress-induced depression by regulating nucleoside release in mice

Trigonelline through the Attenuation of Oxidative Stress Exerts Antidepressant- and Anxiolytic-Like Effects in a Mouse Model of Maternal Separation Stress

Contact Info

Product

Resources

About