Effects of a Purified Micronized Flavonoid Fraction on Capillary Filtration in Diabetic Patients

Abstract

The objective of the present study was to investigate the effects of a purified micronized flavonoid fraction (Daflon 500 mg) on the increased capillary filtration of albumin (CFA) which is an early change in the microcirculation of patients with diabetes. A placebo controlled trial lasting 30 to 42 days including two equal groups of 20 patients, following a 15‐day initial placebo run‐in phase. The CFA test employed consisted of injecting albumin labelled with technetium (99mTc) intravenously, applying a venous tourniquet to one arm, and counting the radioactivity on the ipselateral forearm using an external gamma camera. The disappearance of radioactivity was analysed by means of two parameters after the tourniquet had been released, i.e. albumin retention (AR) and the LF/HF index which indicates lymphatic function in interstitial protein clearance. All patients included exhibited an increase in these two indices before the initial placebo run‐in phase and at the end of the run‐in period. At the end of the treatment phase, AR had significantly decreased in the group treated by the flavonoid fraction (FF) by comparison with the placebo group, and had normalized in 65 % of patients in the FF group, compared with 25 % of patients in the placebo group (p = 0.010). The LF/HF index normalized in 55 % of cases in the FF group, compared with no patients on placebo (p = 0.00001). This study suggests that the flavonoid fraction tested here can improve and even normalize capillary filtration of albumin in diabetic patients.

Clean recovery of antioxidant flavonoids from citrus peel: Optimizing an aqueous ultrasound-assisted extraction method

“…It is known that hesperidin improves the vascular integrity, decreases capillary permeability and is given as a supplement to patients with blood vessel fragility (Valensi et al, 1996). Hesperidin also shows anti-inflammatory and immunomodulatory effects (Yeh et al, 2007).…”

Extra cellular water and increase in capillary permeability to albumin in overweight women with swelling syndrome

“…Reproducibility was also veri®ed with a 1 month interval in diabetic patients. 21 We also con®rmed the reproducibility by carrying out the same procedure 1 h after labelled-albumin injection and inducing a second venous compression for 12 min (unpublished data). 22 …”

“…In the 16 controls investigated in the present study, LFaHF was 0.08AE 0.21%. 21 A value !1% was thus considered to be abnormal. This ratio is an index of lymphatic uptake of interstitial albumin and is not believed to re¯ect a phenomenon which occurs in blood circulation.…”

Antioxidant -Rich Natural Products and Diabetes Mellitus

“…Also, its anti-inflammatory and anti-apoptotic activity has been demonstrated in neuronal cells [99]. Diosmin was found to be capable of normalizing capillary filtration rate and prevent ischemia in diabetics [100][101]. Diosmin has been shown to improve factors associated with diabetic complications.…”