Effects of a propriety oiled mixed hay feeding system on lung function, neutrophilic airway inflammation and oxidative stress in severe asthmatic horses

Jochmans-Lemoine, Alexandra; Picotte, Khristine; Beauchamp, Guy; Vargas, Amandine; Lavoie, Jean‐Pierre

doi:10.1111/evj.13218

Cited by 10 publications

(23 citation statements)

References 33 publications

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“…It also was not possible to impute causality to our observations, especially because exacerbation of asthma in horses is intrinsically linked to a change in diet. This could change in the future, by inducing exacerbation without changing the diet with methods using hay mixed with oil to maintain horses in remission thus decreasing inhaled antigens without changing the type of diet …”

Section: Discussionmentioning

confidence: 99%

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Fecal microbiota in horses with asthma

Leclère

Costa

2020

Veterinary Internal Medicne

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Background Gastrointestinal microbiota can be influenced by several factors, including diet and systemic inflammation, and in turn could act as a modulator of the allergic response. Fecal microbiota of horses with asthma has not been described. Hypothesis/Objectives Analyze the bacterial fecal microbiota of horses with and without asthma under different environment and diet conditions, during both remission and exacerbation. Methods Prospective observational study. Feces from 6 asthmatic and 6 healthy horses were collected under 3 different conditions: on pasture, housed indoors receiving good quality hay (“good hay”), and housed indoors receiving poor quality hay (“dusty hay”). Sequencing was performed using an Illumina MiSeq platform and data were processed using the software mothur v.1.41.3 and LEfSe. Results In horses with asthma, low‐abundance bacteria were more affected by changes in environment and diet (ie, when horses were experiencing an exacerbation), as shown by changes in membership and results from the LEfSe analysis. There was a significant increase in the relative abundance of Fibrobacter in healthy horses eating hay, a change that was not observed in horses with asthma. Conclusions and Clinical Importance The intestinal microbiota of horses with asthma does not adapt in the same way to changes in diet and environment compared to the microbiota of healthy horses. Mechanisms explaining how airway obstruction and inflammation could influence the intestinal microbiota and how in turn this microbiota could modulate systemic inflammation in asthmatic horses deserves further investigation.

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Section: Discussionmentioning

confidence: 99%

“…This could change in the future, by inducing exacerbation without changing the diet with methods using hay mixed with oil to maintain horses in remission thus decreasing inhaled antigens without changing the type of diet. 31…”

Section: Limitationsmentioning

confidence: 99%

Fecal microbiota in horses with asthma

Leclère

Costa

2020

Veterinary Internal Medicne

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“…Stables compromise both physical and visual contact and frequently have poor circulation and air quality, with high ammonia concentrations, and dust/moulds from hay, straw and bedding. The respiratory system of the horse is compromised [ 51 ] and obstructive pulmonary disease may ensue [ 52 ]. Huffman [ 51 ] suggested that adequate ventilation should be mandatory in all new stabling, including ceiling fans.…”

Section: Discussionmentioning

confidence: 99%

“…In the 19th century rail travel became increasingly popular for moving horses but it is now common to fly racehorses to interstate race meetings. Dehydration and weight loss are risks in all long distance transport, as is Shipping Fever caused by a horse’s head being tied in such a way as to prevent it being lowered or raised, thus preventing effective draining of the upper respiratory tract [ 52 ]. Shipping fever is also a major concern with air transportation [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of Thoroughbred Racehorse Welfare Issues by Industry Stakeholders

Mactaggart

Waran

Phillips

2021

Animals

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Identifying key welfare issues for thoroughbred racehorses could lead to an improvement in standards. A lack of scientific information on the relative importance of key issues was addressed by soliciting the views of, first, welfare experts in the industry and, second, a broader group of stakeholders, who selected the best welfare options by adaptive conjoint analysis. The experts represented racehorse breeders, veterinarians, trainers, owners, government officials, salespeople, farriers, transporters, and horse re-trainers for post-racing activities. In a focus group meeting, the experts identified fourteen key welfare issues, each with two to four levels that related to common husbandry practices. Then, in an internet survey, 224 stakeholders ranked the issues using adaptive conjoint analysis, in declining importance, as: horsemanship > health and disease > education of the horse > track design and surface > ventilation > stabling > weaning > transport > nutrition > wastage > heat and humidity > whips > environment > gear. Relatively uniform responses to the survey by the different stakeholder groups suggested that there was a common view on what had the biggest impact on welfare. An exception was a greater rating given by women than men to the importance of correct horse nutrition. The rating of importance for welfare of different levels of provision of each issue mostly conformed to the scientific evidence, with the exception of weaning. This understanding of the importance of welfare issues for thoroughbred racehorses could be used to target interventions to the most serious problems.

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“…7,8 But the resolution of neutrophilic inflammation may require months of low-dust conditions. 9,10 Airway inflammation in human asthmatics is thought to reflect a failure to resolve inflammation, thereby preventing a return to homeostasis after an inflammatory trigger. 11 The fatty acid composition of an individual's diet influences the formation of inflammatory mediators related to many chronic diseases, such as…”

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confidence: 99%

Effects of forages, dust exposure and proresolving lipids on airway inflammation in horses

Olave

Ivester

Couëtil

et al. 2022

ajvr

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OBJECTIVE To investigate the role of omega-3 polyunsaturated fatty acids (Ω-3)–derived proresolving lipid mediators (PRLM) in the resolution of mild airway inflammation in horses. ANIMALS 20 horses with mild airway inflammation. PROCEDURES Horses previously eating hay were fed hay pellets (low Ω-3 content; n = 10) or haylage (high Ω-3 content; 9) for 6 weeks. Dust exposure was measured in the breathing zone with a real-time particulate monitor. Bronchoalveolar lavage (BAL) was performed at baseline, week 3, and week 6. The effect of PRLM on neutrophil apoptosis and efferocytosis was examined in vitro. BAL fluid inflammatory cell proportions, apoptosis of circulating neutrophils, efferocytosis displayed by alveolar macrophages, and plasma lipid concentrations were compared between groups fed low and high amounts of Ω-3 by use of repeated measures of generalized linear models. RESULTS Dust exposure was significantly higher with hay feeding, compared to haylage and pellets, and equivalent between haylage and pellets. BAL fluid neutrophil proportions decreased significantly in horses fed haylage (baseline, 11.8 ± 2.4%; week 6, 2.5 ± 1.1%) but not pellets (baseline, 12.1 ± 2.3%; week 6, 8.5% ± 1.7%). At week 6, horses eating haylage had significantly lower BAL neutrophil proportions than those eating pellets, and a significantly lower concentration of stearic acid than at baseline. PRLM treatments did not affect neutrophil apoptosis or efferocytosis. CLINICAL RELEVANCE Despite similar reduction in dust exposure, horses fed haylage displayed greater resolution of airway inflammation than those fed pellets. This improvement was not associated with increased plasma Ω-3 concentrations. Feeding haylage improves airway inflammation beyond that due to reduced dust exposure, though the mechanism remains unclear.

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Effects of a propriety oiled mixed hay feeding system on lung function, neutrophilic airway inflammation and oxidative stress in severe asthmatic horses

Cited by 10 publications

References 33 publications

Fecal microbiota in horses with asthma

Fecal microbiota in horses with asthma

Identification of Thoroughbred Racehorse Welfare Issues by Industry Stakeholders

Effects of forages, dust exposure and proresolving lipids on airway inflammation in horses

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