Effects of a prophylactic or therapeutic application of perflubron emulsion on myocardial ischaemia-reperfusion injury in rats

Abstract

Although administration of perflubron emulsion did not reduce infarct size, areas of impaired perfusion were significantly mitigated when perflubron emulsion was administered prior to coronary occlusion. However, a high oxygen concentration may provoke DNA strand breaks during reperfusion after ischaemia. Further studies must clarify whether enhanced oxidative stress outweighs the advantage of improved areas of impaired perfusion following perflubron emulsion.

Perfluorocarbon‐Based Oxygen Carriers: Review of Products and Trials

“…Coronary occlusion. This product did not reduce infarct size, but mitigated areas of impaired perfusion when it was administered prior to coronary occlusion in rats (48).…”