Background and Purpose-The aims of this study were to determine the magnitude of the increase in fracture risk after hospitalization for stroke, and in particular to determine the time course of this risk. Methods-The records of the Swedish register of patients admitted during 1987-1996 were examined to identify all patients who were admitted to the hospital for stroke. Patients were followed for subsequent hospitalizations for hip and all fractures combined. We analyzed 16.3 million hospitalizations, from which 273 288 individuals with stroke were identified. A Poisson model was used to determine the absolute risk of subsequent fractures and the risk compared with that of the general population. Results-After hospitalization for stroke, there was a ÏŸ7-fold increase in fracture risk, including that for hip fracture within the first year after hospitalization for stroke. Thereafter, fracture risk declined toward, but did not attain, the baseline risk except in men and women aged Ő80 years. Population studies suggest that the risk of fracture is increased approximately 2-to 4-fold. [1][2][3][4][5] Hip fracture occurs most commonly on the paretic side and is usually trochanteric, most likely due to a high risk of falling on the affected side. 3 Although less extensively studied, an increase in risk is seen in men as well as in women. 5,6 A gap in our epidemiological knowledge of relevance to treatment is whether the risk of fracture is highest in the months after stroke or remains consistently increased.
Conclusions-TheWe have shown in a previous study that the risk of all fractures, including that of hip fracture, increases markedly after hospitalization for vertebral fracture. The increase in risk was particularly evident in the first year immediately after a vertebral fracture, and rates declined thereafter toward that of the general population. 7 The increase in risk was much greater than that likely on the basis of changes in bone density, suggesting that other factors associated with hospitalization were important for the transient increment in risk.The aims of the present study were to examine whether stroke might be associated with a transient increase in risk after the acute event. If a high but transient risk of fracture occurred, this might suggest that interventions could be offered to cover this acute period of risk rather than for the remaining lifetime of individuals. The aim of the present study was therefore to determine the time course of any increase in fracture risk after stroke.
Subjects and MethodsWe studied 16.3 million admissions to Swedish hospitals during 1987-1996. Our source was the National Swedish Register (the patient register of the National Board of Health and Welfare), which documents each hospital admission. A unique personal identifier permitted the tracking of individuals for multiple admissions. All patient records were examined to identify individuals who were admitted to the hospital for a stroke during the 10-year interval. Patients with International Classification of Disea...