Effects of a polysaccharide-based multi-ingredient supplement on salivary immunity in non-elite marathon runners

Roca, Emma; Cantó, Elisabet; Nescolarde, Lexa; Perea, Lídia; Bayés‐Genís, Antoni; Sibila, Oriol; Vidal, Sílvia

doi:10.1186/s12970-019-0281-z

Cited by 6 publications

(6 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sixth, corrections for plasma volume change that can occur following an acute bout of exercise has been recommended when studying serum biomarkers (Kargotich et al, 1997); however, this does not apply to all published studies (Neidhart et al, 2000;Kersting et al, 2005;Mündermann et al, 2005;Niehoff et al, 2011). Immediate and 48-h post-marathon plasma volume change determined with haemoglobin and haematocrit data of a previous study of our group (Roca et al, 2019) in 41 runners of 2016 Barcelona Marathon was −1.2 and −1.7%, respectively. The percentage of biomarker change when correcting for plasma volume is small, and we believe it would apply to our study.…”

Section: Discussionmentioning

confidence: 98%

“…We examined the dynamics of a panel of inflammatory, high-energy, and cartilage biomarkers in non-elite athletes completing the Barcelona Marathon in 2017. These new data were recorded as part of the SUMMIT Project, whose main goal is analysing health risk in the population engaged in high-intensity physical activities (Maqueda et al, 2017;Roca et al, 2017Roca et al, , 2019Nescolarde et al, 2020). The procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Marathon Running Increases Synthesis and Decreases Catabolism of Joint Cartilage Type II Collagen Accompanied by High-Energy Demands and an Inflamatory Reaction

Hernández-Hermoso

Nescolarde

Roca³

et al. 2021

Front. Physiol.

Self Cite

View full text Add to dashboard Cite

Objective: To determine the effect of marathon running on serum levels of inflammatory, high energy, and cartilage matrix biomarkers and to ascertain whether these biomarkers levels correlate.Design: Blood samples from 17 Caucasian male recreational athletes at the Barcelona Marathon 2017 were collected at the baseline, immediately and 48 h post-race. Serum C reactive protein (CRP), creatin kinase (CK), and lactate dehydrogenase (LDH) were determined using an AU-5800 chemistry analyser. Serum levels of hyaluronan (HA), cartilage oligomeric matrix protein (COMP), aggrecan chondroitin sulphate 846 (CS846), glycoprotein YKL-40, human procollagen II N-terminal propeptide (PIINP), human type IIA collagen N-propeptide (PIIANP), and collagen type II cleavage (C2C) were measured by sandwich enzyme-linked immune-sorbent assay (ELISA).Results: Medians CK and sLDH levels increased (three-fold, two-fold) post-race [429 (332) U/L, 323 (69) U/L] (p < 0.0001; p < 0.0001) and (six-fold, 1.2-fold) 48 h post-race [658 (1,073) U/L, 218 (45) U/L] (p < 0.0001; p < 0.0001). Medians CRP increased (ten-fold) after 48 h post-race [6.8 (4.1) mg/L] (p < 0.0001). Mean sHA levels increased (four-fold) post-race (89.54 ± 53.14 ng/ml) (p < 0.0001). Means PIINP (9.05 ± 2.15 ng/ml) levels increased post-race (10.82 ± 3.44 ng/ml) (p = 0.053) and 48 h post-race (11.00 ± 2.96 ng/ml) (p = 0.001). Mean sC2C levels (220.83 ± 39.50 ng/ml) decreased post-race (188.67 ± 38.52 ng/ml) (p = 0.002). In contrast, means COMP, sCS846, sPIIANP, and median sYKL-40 were relatively stable. We found a positive association between sCK levels with sLDH pre-race (r = 0.758, p < 0.0001), post-race (r = 0.623, p = 0.008) and 48-h post-race (r = 0.842, p < 0.0001); sHA with sCRP post-race vs. 48 h post-race (r = 0.563, p = 0.019) and sPIINP with sCK pre-race vs. 48-h post-race (r = 0.499, p = 0.044) and with sLDH 48-h pre-race vs. post-race (r = 0.610, p = 0.009) and a negative correlation of sPIIANP with sCRP 48-h post-race (r = −0.570, p = 0.017).Conclusion: Marathon running is an exercise with high-energy demands (sCK and sLDH increase) that provokes a high and durable general inflammatory reaction (sCRP increase) and an immediately post-marathon mechanism to protect inflammation and cartilage (sHA increase). Accompanied by an increase in type II collagen cartilage fibrils synthesis (sPIINP increase) and a decrease in its catabolism (sC2C decrease), without changes in non-collagenous cartilage metabolism (sCOMP, sC846, and sYKL-40). Metabolic changes on sPIINP and sHA synthesis may be related to energy consumption (sCK, sLDH) and the inflammatory reaction (sCRP) produced.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Methodsmentioning

confidence: 99%

Marathon Running Increases Synthesis and Decreases Catabolism of Joint Cartilage Type II Collagen Accompanied by High-Energy Demands and an Inflamatory Reaction

Hernández-Hermoso

Nescolarde

Roca³

et al. 2021

Front. Physiol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…This study showed that short-term changes in daily movement behavior could significantly affect sCRP levels in a way that increased steps per day can decrease sCRP levels and vice versa. Moreover, as shown by Roca et al ( 98 ) in a sample of 41 male marathon runners sCRP levels significantly increased 48 hours after marathon.…”

Section: Resultsmentioning

confidence: 53%

The Role of Salivary C-Reactive Protein in Systemic and Oral Disorders: A Systematic Review

Babaei

Rezaei

Khadem

et al. 2022

Med. J. Islam. Republ. Iran

View full text Add to dashboard Cite

“…For example, Ambrotose glyconutrients have been associated with improvements in memory and subjective ratings of well-being in numerous studies [4,5,15,16]. With regards to immune modulation, marathon runners ingesting Advanced Ambrotose daily for 15 days prior to competition exhibited lower resting salivary chemokines, Gro-alpha and Gro-beta, compared to nonsupplemented counterparts; however, supplemented runners did not experience a reduction in these markers after exercise but did experience a reduction in the salivary chemokine, angiogenin, after exercise [17]. Alternatively, Ambrotose glyconutrients can also be offered with added antioxidants (Ambrotose AO).…”

Section: Discussionmentioning

confidence: 99%

An Assessment of the Glyconutrient Ambrotose™ on Immunity, Gut Health, and Safety in Men and Women: A Placebo-Controlled, Double-Blind, Randomized Clinical Trial

2020

View full text Add to dashboard Cite

Background: Certain dietary fibers have been reported to improve gut health and cellular immunity. Ambrotose is a glyconutrient supplement that contains mannose-rich polysaccharides (acemannan), reported to improve immune function. A more nutrient-dense version of this dietary supplement has been developed recently, with added aloe leaf gel powder (acemannan). The purpose of this study was to evaluate the impact of the traditional and newly developed Ambrotose products on immunity, gut health, and psychological well-being in healthy men and women. Methods: Seventy-five men and women were randomly assigned in double-blind manner to one of five treatments, as follows: Ambrotose Advanced (AA) at 2 or 4 g daily, Ambrotose LIFE (AL) at 2 or 4 g daily, or placebo. Subjects ingested their assigned treatment daily for eight weeks. Resting heart rate, blood pressure, and measures of psychological well-being were analyzed before and after four and eight weeks of supplementation. Blood samples were collected at the same times and analyzed for zonulin, hematology measures, and cytokines—IL-6, IL-10, IL-1β, and TNF-α (analyzed both with and without stimulation via lipopolysaccharide [LPS]). Results: All Ambrotose treatments were well-tolerated. There were no differences among treatments in heart rate or blood pressure across time. Self-reported well-being scores were generally higher for the Ambrotose treatments but there were no changes of statistical significance across time (p > 0.05). Differences of statistical significance were noted for select biochemical variables, the most notable being a dramatic decrease in monocytes in the Ambrotose groups. No change was noted in the cytokine response to LPS stimulation in all groups, indicating a maintenance of a healthy immune response. Conclusion:Regular supplementation with Ambrotose is safe and can improve subclinical cellular adversity (as evidenced by a decrease in monocytes), without unnecessary activation of an immune response.

show abstract

Effects of a polysaccharide-based multi-ingredient supplement on salivary immunity in non-elite marathon runners

Cited by 6 publications

References 36 publications

Marathon Running Increases Synthesis and Decreases Catabolism of Joint Cartilage Type II Collagen Accompanied by High-Energy Demands and an Inflamatory Reaction

Marathon Running Increases Synthesis and Decreases Catabolism of Joint Cartilage Type II Collagen Accompanied by High-Energy Demands and an Inflamatory Reaction

The Role of Salivary C-Reactive Protein in Systemic and Oral Disorders: A Systematic Review

An Assessment of the Glyconutrient Ambrotose™ on Immunity, Gut Health, and Safety in Men and Women: A Placebo-Controlled, Double-Blind, Randomized Clinical Trial

Contact Info

Product

Resources

About