Effects of a parallel-arm randomized controlled weight loss pilot study on biological and psychosocial parameters of overweight and obese breast cancer survivors

Abstract

BackgroundWeight gain often occurs after breast cancer (BC) diagnosis and obesity along with sedentary behavior are associated with increased risk of BC recurrence and mortality. The primary objective of this study was to determine whether a significant weight loss, of approximately 10%, would lead to beneficial changes in biomarkers associated with cancer and/or cancer recurrence, and quality of life (QOL) in overweight and obese BC survivors.MethodsThis parallel-arm study took place in Minneapolis, Minnesota, from January 2009 until March 2010. Participants were overweight and obese postmenopausal BC survivors who had completed treatment at least 3 months prior to enrollment and who did not smoke. Twenty-one BC survivors were randomized, via a random number generator computer software, to a 1000-calorie deficit feeding and exercise intervention (CR) or a weight management counseling intervention (WM) for 12 weeks followed by a 6-week follow-up. Body weight, biomarkers, and QOL were measured at baseline, weeks 6, 12, and 18. Body composition and fitness level were measured at only two time points.ResultsTwenty-one women were enrolled into the study and 20 completed all time points. Weight loss occurred with both interventions. Body weight in CR changed from 85.5 (95% confidence interval (CI) 77, 94) kg to 76.7 (95% CI 68.1, 85.2) kg, whereas in WM it changed from 98.3 (95% CI 89.8, 106.8) kg to 93.2 (95% CI 84.6, 101.7) kg. Fitness in CR changed from 4.9 (95% CI 4, 5.8) to 6.3 (95% CI 5.4, 7.2). CR led to lower plasma levels of leptin, F2-isoprostanes, and CRP. Quality of life seemed to improve with both interventions, while sleep quality decreased only in CR.ConclusionsOverweight and obese BC survivors were able to adhere to a strict diet and exercise program, which significantly decreased body weight, increased fitness level, and improved biomarkers and QOL. However, the strict dietary intervention in CR seemed to decrease participants’ sleep quality and social relationships. Future larger randomized controlled trials should focus on behavioral modification and personalized nutrition counseling to help breast cancer survivors achieve a sustainable weight loss and fitness level.Trial registrationClinicalTrials.gov identifier: NCT02940470.

Calorie restriction and synbiotics effect on quality of life and edema reduction in breast cancer-related lymphedema, a clinical trial

“…Furthermore, BMI was significantly reduced by 3.01% in the CRS group and 2.15% in the CRP group compared to the control, and this may correlate with a better quality of life. Arikawa [ 38 ] and wahnefried [ 39 ] in different studies approved the improved quality of life in breast cancer survivors following a weight loss. It seems that weight loss is so effective in these patients that it is better to be included in the lymphedema treatment protocols.…”

Obesity, Dietary Factors, Nutrition, and Breast Cancer Risk

“…Weight loss interventions and dietary education after breast cancer diagnosis can help patients to improve their diet quality, achieve desired weight loss, increase their cardiorespiratory fitness, and improve their overall quality of life, fatigue, body image, and lower incidence of comorbidities and favor changes in biomarkers related to breast cancer risk and prognosis (e.g., blood glucose, blood lipids, CRP, DNA methylation) [113, 155, 160, 164–167]. In addition, physical activity during and after treatment can help patients to manage treatment side effects, reduce cancer-related fatigue, improve quality of life and functional capacity, promote alterations in bio-markers, and potentially enhance the overall prognosis and survival of breast cancer patients and survivors [168, 169].…”

“…In addition, physical activity during and after treatment can help patients to manage treatment side effects, reduce cancer-related fatigue, improve quality of life and functional capacity, promote alterations in bio-markers, and potentially enhance the overall prognosis and survival of breast cancer patients and survivors [168, 169]. On the other hand, in one study, adhering to a strict dietary intervention resulted in decreased sleep quality in breast cancer patients, indicating that changing dietary behaviors can be both challenging and stressful [160]. …”

“…Weight gain after breast cancer treatment confers a poor prognosis and may increase recurrence rates. Adopting a healthy lifestyle, that is eating a healthy diet, engaging in physical activity, and maintaining a healthy weight following cancer treatment, has been shown to improve the quality of life and overall outcome of cancer survivors [155, 160].…”

Farklı kültürlerde jinekolojik ve meme kanserli kadın hastaların seksüaliteye bakış açıları ve yaşadıkları sorunlar

“…[59] SONUÇ Sonuç olarak kanser, gerek hastalığın kendisi gerekse uygulanan tedaviler nedeniyle, birtakım fizyolojik değişimlere yol açmasının yanı sıra, bireylerin ve aile üyelerinin yaşam kalitesinin azalmasıyla ilişkili olarak depresyon, kaygı, benlik saygısının bozulması, stres, psikolojik ve duygusal refahta azalma gibi ciddi ve şiddetli psikososyal etkilere neden olmaktadır. [63][64][65][66][67][68] Bireyin fiziksel sağlık, psikolojik durum, bağımsızlık seviyesi, kişisel inançları, sosyal ilişkileri gibi varlığının tüm yönlerini kapsayan yaşam kalitesinin önemli bir boyutu olan cinsellik de bu süreçte çok boyutlu olarak etkilenmektedir. [66,69,70] Hakem Değerlendirmesi…”