Effects of a palatinose-based liquid diet (Inslow) on glycemic control and the second-meal effect in healthy men

Arai, Hidekazu; Mizuno, Akira; Sakuma, Masae; Fukaya, Makiko; Matsuo, Kaoru; Muto, Kazusa; Sasaki, Hajime; Matsuura, Motoi; Okumura, Hisami; Yamamoto, Hironori; Taketani, Yutaka; Doi, Toshio; Takeda, Eiji

doi:10.1016/j.metabol.2006.09.005

Cited by 59 publications

(48 citation statements)

References 52 publications

(50 reference statements)

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“…In the current study, no differences in fasted glucose and insulin levels were noted between rats fed palatinose and sucrose for four weeks. Nevertheless, postprandial glucose and insulin levels, which were not measured, might have differed as reported previously by our group (10,11). Other investigators have also reported that sucrose and other high glycemic starch amylopectin can induce islet hypertrophy (31)(32)(33).…”

Section: Discussionmentioning

confidence: 54%

“…Although palatinose is completely hydrolyzed and absorbed, the hydrolysis rate of palatinose in rat and human intestine averages only 11-25 % (30), resulting in suppression of postprandial/fasted hyperglycemia and hyperinsulinemia relative to sucrose (4,10,11). Although the mechanistic details are unclear, the preventing effect of palatinose or aggravating effect of sucrose on islet hypertrophy may be due to the opposing effects of these sugars on glycemia and insulinotropy.…”

Section: Discussionmentioning

confidence: 99%

“…Diets consist of food mixtures containing complex combinations of interactive and synergistic nutrients, and these combinations and interactions need to be taken into account. We reported previously that a liquid balanced formula (MHN-01/Inslow " " ) containing palatinose and oleic acid suppressed postprandial hyperglycemia and hyperinsulinemia, reduced visceral fat accumulation, and improved insulin sensitivity in healthy men and Sprague-Dawley rats (10,11). We also have shown that various symptoms of obesity in Zucker fatty (fa/fa) rats were attenuated by longterm (8 wk) consumption of a diet containing palatinose and oleic acid, but aggravated by a diet containing sucrose and linoleic acid (12).…”

Section: Introductionmentioning

confidence: 99%

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Palatinose and oleic acid act together to prevent pancreatic islet disruption in nondiabetic obese Zucker rats

et al. 2008

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: We showed previously that 8-wk consumption of a diet containing palatinose (P, a slowly-absorbed sucrose analogue) and oleic acid (O) ameliorates but a diet containing sucrose (S) and linoleic acid (L) aggravates metabolic abnormalities in Zucker fatty (fa/fa) rats. In this study, we aimed to identify early changes in metabolism in rats induced by certain combinations of carbohydrates and fatty acids. Specifically, male Zucker fatty rats were fed an isocaloric diet containing various combinations of carbohydrates (P ; S) and fatty acids (O ; L). After 4 wk, no significant differences in body weight, visceral fat mass, plasma parameters (glucose, insulin, lipids, and adipokines), hepatic adiposity and gene expression, and adipose inflammation were observed between dietary groups. In contrast, pancreatic islets of palatinose-fed (PO and PL) rats were smaller and less fibrotic than sucrose-fed (SO and SL) rats. The abnormal ! -cell distribution and sporadic staining of active caspase-3 common to islets of linoleic-acid-fed rats were not observed in oleic-acid-fed (PO and SO) rats. Accordingly, progressive " -cell loss was seen in SL rats, but not in PO rats. These findings suggest that pancreatic islets may be initial sites that translate the effects of different combinations of dietary carbohydrates and fats into metabolic changes.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Palatinose and oleic acid act together to prevent pancreatic islet disruption in nondiabetic obese Zucker rats

et al. 2008

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“…A previous report showed the second-meal effect of ingesting a low-glycemic-index breakfast [30]. A possible explanation might lie in the fluctuations of plasma glucose, serum insulin and NEFA that occurred with the intake of the GL.…”

Section: Discussionmentioning

confidence: 99%

Gene Expression Profiling in Peripheral White Blood Cells in Response to the Intake of Food with Different Glycemic Index Using a DNA Microarray

et al. 2013

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Background/Aims: Transcriptomics technology in human nutrition intervention studies would allow for genome-wide screening of the effects of nutrients. We observed the time course of gene expression changes in peripheral white blood cells (WBC) to elucidate the metabolic changes in the postprandial state that are a reflection and a marker of whole body metabolic changes. Methods: In a randomized crossover study, 7 healthy subjects consumed test meals of glucose (GL), white rice (WR) and rolled barley (BAR), each containing 75 g of available carbohydrate, and water (WAT). Blood glucose, insulin and nonesterified fatty acid concentrations, as well as the subjective levels of fullness and hunger were measured. Microarray analysis of the WBC and the real-time PCR were examined during 360 min after the intake of the test meals. Results: The number of genes that changed more than 1.5-fold and the expression patterns in the time course were different between the GL, the WR and the BAR groups. Several genes involved in glycolysis and fatty acid β-oxidation were markedly changed after the intake of the GL, the WR and the BAR; however, these genes did not change at any time point in the WAT. Conclusions: Gene expression profiling in the WBC can reflect food-related metabolic changes, even in the postprandial state.

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“…Very recently, acute effects of PBF ingestion on postprandial glucose levels and FFA were reported (Arai et al 2007). In the report, consumption of PBF at breakfast has been shown to improve postprandial glucose levels after lunch, where PBF were not consumed.…”

Section: Discussionmentioning

confidence: 99%

A Palatinose-Based Balanced Formula Improves Glucose Tolerance, Serum Free Fatty Acid Levels and Body Fat Composition

Oizumi

Daimon

Jimbu

et al. 2007

Tohoku J. Exp. Med.

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Palatinose is a disaccharide present in honey, which has the characteristics of delayed digestion and absorption. We developed a palatinosebased balanced formula (PBF) and reported its beneficial effects on metabolic syndromerelated parameters in rats. To examine the effects of PBF in humans, we here conducted a crossover study using twenty-three subjects with impaired glucose tolerance. The subjects were divided into two groups: intervention to control (I/C) and control to intervention (C/I) groups. The I/C group consumed PBF (250 kcal) together with foods that were 250 kcal less than their usual breakfast (intervention meal) for the first 12 weeks, followed by their usual breakfast (control meal) for the last 12 weeks. The protocol for the C/I group was opposite in order: the control meal for the first 12 weeks, followed by the intervention meal for the last 12 weeks. In the first 12-week period, the intervention meal decreased 2-hr plasma glucose levels after 75-g oral glucose tolerance test (-15.7 ± 20.1% change), while the control meal did not (0.8 ± 31.6% change). The difference between these changes was significant ( p = 0.038). The similar results were obtained from the comparison of the changes between the first and the last 12-week periods in the two groups combined (intervention vs control: -11.8 ± 22.5 vs 11.2 ± 30.2% change, p = 0.024). PBF also had the beneficial effects on serum free fatty acids levels and visceral fat area. In conclusion, PBF consumption has beneficial effects on metabolic syndrome-related parameters in humans.palatinose; free fatty acid; visceral fat area; glucose tolerance; metabolic syndrome © 2007 Tohoku University Medical Press As shown in many studies, sustained hyperglycemia is a risk factor for both microvascular and macrovascular (or cardiovascular) complications in type 2 diabetes (DM) (Laakso and Lehto 1997; UK Prospective Diabetes Study group 1998; Bretzel et al. 1998), while postprandial

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Effects of a palatinose-based liquid diet (Inslow) on glycemic control and the second-meal effect in healthy men

Cited by 59 publications

References 52 publications

Palatinose and oleic acid act together to prevent pancreatic islet disruption in nondiabetic obese Zucker rats

Palatinose and oleic acid act together to prevent pancreatic islet disruption in nondiabetic obese Zucker rats

Gene Expression Profiling in Peripheral White Blood Cells in Response to the Intake of Food with Different Glycemic Index Using a DNA Microarray

A Palatinose-Based Balanced Formula Improves Glucose Tolerance, Serum Free Fatty Acid Levels and Body Fat Composition

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