Effects of a novel formulation of essential oils on glucose– insulin metabolism in diabetic and hypertensive rats: a pilot study

Talpur, Nadeem; Echard, Bobby; Ingram, Cass; Bagchi, Debasis; Preuss, Harry G.

doi:10.1111/j.1463-1326.2004.00386.x

Cited by 85 publications

(55 citation statements)

References 33 publications

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“…[50] The combination of cinnamon essential oil with cumin, fennel, oregano, and myrtle essential oils has a synergetic effect on the reduction of blood glucose levels as well as enhancing insulin sensitivity in type 2 diabetes in a rat model. [51] In the study of Cheng et al, [23] defatted soy flour enriched with cinnamon extract had a significant effect on improving glucose metabolism in both in vivo and in vitro experimentation.…”

Section: Antitumor and Anticancermentioning

confidence: 99%

Cinnamon and its derivatives as potential ingredient in functional food—A review

Muhammad

Dewettinck

2017

International Journal of Food Properties

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Cinnamon has been reported to have significant benefits for human health, particularly as an anti-inflammatory, antitumor, anticancer, antidiabetic, and anti-hypertriglyceridemia agent, mainly due to its phytochemical constituents such as phenolic and volatile compounds. The phytochemicals in cinnamon can be extracted from different parts of plant by distillation and by solvent extraction. The use of cinnamon in food and its ability to prevent oxidation and inhibit microbial growth are covered in this review. Its bioaccessibility, safety, and consumer acceptance are comprehensively discussed. This review also clearly shows a route to the use of cinnamon as an ingredient in functional foods. ARTICLE HISTORY

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Section: Antitumor and Anticancermentioning

confidence: 99%

Cinnamon and its derivatives as potential ingredient in functional food—A review

Muhammad

Dewettinck

2017

International Journal of Food Properties

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“…Both in vitro and in vivo animal studies have shown that cinnamon is an insulin sensitizer. 2 Several compounds within cinnamon have been identified as possible sources of this sensitization process.…”

Section: Unanswered Questions and Future Researchmentioning

confidence: 99%

Effectiveness of Cinnamon for Lowering Hemoglobin A1C in Patients with Type 2 Diabetes: A Randomized, Controlled Trial

Crawford¹

2009

The Journal of the American Board of Family Medicine

211

173

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Purpose: Multiple trials in the past have shown conflicting results of whether cinnamon lowers glucose or hemoglobin A1C (HbA1C). The purpose of this study was to determine whether cinnamon lowers HbA1C in patients with type 2 diabetes. I performed a randomized, controlled trial to evaluate whether daily cinnamon plus usual care versus usual care alone lowers HbA1c.Methods: I randomized 109 type 2 diabetics (HbA1C >7.0) from 3 primary care clinics caring for pediatric, adult, and geriatric patients at a United States military base. Participants were randomly allocated to either usual care with management changes by their primary care physician or usual care with management changes plus cinnamon capsules, 1g daily for 90 days. HbA1c was drawn at baseline and 90 days and compared with intention-to-treat analysis. This study was approved by an institutional review board.Results As the worldwide incidence of diabetes increases, the search for dietary adjuncts to treat this lifealtering disease has become far ranging. Cinnamon is purported to be a natural insulin sensitizer, with adverse events of perioral dermatitis and stomatitis reported uncommonly with high intake.1 Both in vitro and in vivo animal studies have shown that cinnamon is an insulin sensitizer. found that polyphenols from cinnamon inhibit the formation of advanced glycation end products in bovine serum albumin. To date, 5 randomized trials studying cinnamon in humans with type 2 diabetes have been published, with conflicting results. 6 -10 The results of these studies are mixed, and it is unclear whether any of them were conducted among primary care populations. Two of these studies showed a possible effect of cinnamon on fasting serum glucose, but they did not examine hemoglobin A1C (HbA1C) levels. One study showed no effect on plasma glucose. Two studies-one each done with patients with type 1 and type 2 diabetes-showed no effect of cinnamon on HbA1C (Table 1). A meta-analysis of these studies in divergent populations measuring different parameters showed no effect of cinnamon on HbA1C, glucose, or lipids. 11This trial strove to replicate the conditions found in primary care, where patients often have medication changes, comorbid conditions, and dietary changes. As such, it was not an efficacy trial with every variable controlled. It attempted to determine whether the intervention of taking cinnamon lowers HbA1C. Effectiveness trials such as this are critical in determining if the interventions This article was externally peer reviewed.

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“…For example, Allium cepa (garden onion) and Momordica charantia (bitter melon) have hypoglycemic effects (13,17,24) and improved insulin action in rats fed a high-fat diet (17), while the medicinal plant, Galega officialis, led to discovery and synthesis of metformin, the well-known hypoglycemic medication (64). Essential (volatile) oils of herbs and medicinal plants have long been known to have antimicrobial, antifungal, and antioxidant properties (10,60), as well as exerting hypoglycemic effects in animal models of type 1 diabetes (54,55), type 2 diabetes (Zucker fatty rats), and insulin resistance (59). Thus, it appears that essential oils offer therapeutic potential for the treatment of insulin resistance, although their mechanism of action remains unknown.…”

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confidence: 99%

Thujone, a component of medicinal herbs, rescues palmitate-induced insulin resistance in skeletal muscle

Alkhateeb

Bonen

2010

American Journal of Physiology-Regulatory, Integrative and Comp

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Effects of a novel formulation of essential oils on glucose– insulin metabolism in diabetic and hypertensive rats: a pilot study

Cited by 85 publications

References 33 publications

Cinnamon and its derivatives as potential ingredient in functional food—A review

Cinnamon and its derivatives as potential ingredient in functional food—A review

Effectiveness of Cinnamon for Lowering Hemoglobin A1C in Patients with Type 2 Diabetes: A Randomized, Controlled Trial

Thujone, a component of medicinal herbs, rescues palmitate-induced insulin resistance in skeletal muscle

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