Effects of a Novel Dietary Supplement on Indices of Muscle Injury and Articular GAG Release in Horses

Lindinger, Michael I.; MacNicol, Jennifer L.; Karrow, Neil A.; Pearson, Wendy

doi:10.1016/j.jevs.2016.08.016

Cited by 5 publications

(5 citation statements)

References 54 publications

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“…But horses having a higher frequency of interaction with their owners tend to receive more nutritional attention; a proposition that is supported by others who observe that people caring for fewer horses tend to have horses that are more overweight than people who are caring for a greater number of horses (Hitchens, Hultgren, Frössling, Emanuelson, & Keeling, ). Further support for the role of AL is evidence that high intensity exercise increases PL‐PGE 2 in equine (Lindinger, MacNicol, Karrow, & Pearson, ) and human athletes under acute exercise conditions (Capó, Martorell, Sureda, Riera et al., ; Capó, Martorell, Sureda, Tur, & Pons, ); an effect that may be augmented, at least in part, by increased production of PGE 2 by polymorphonuclear cells taken from trained vs untrained individuals (Capó, Martorell, Sureda, Riera et al., ). PGE 2 is an important contributor to adaptation to and/or recovery from exercise by inducing vasodilation (Capó, Martorell, Sureda, Riera et al., ), muscle hypertrophy (Burd et al., ) and resolution of inflammation (Serhan, ).…”

Section: Discussionmentioning

confidence: 98%

Exploring relationships between body condition score, body fat, activity level and inflammatory biomarkers

Pearson

Wood

Stanley³

et al. 2018

Animal Physiology Nutrition

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Obesity is associated with inflammatory disorders in humans, including degenerative joint disease. While obesity is endemic in horses, its relationship to equine degenerative joint disease has not been explored. The current study sought to describe relationships between: body weight (BW), body condition score (BCS), lameness grade (AAEP), total body fat mass (kg; FM) and fat per cent (FP) [multifrequency bioelectrical impedance analysis (mfBIA)], age, gender, activity level (AL), synovial fluid (SF) and plasma (PL) PGE and glycosaminoglycan (GAG) in horses. During this field investigation, the BCS (of nine) of 54 horses at multiple farms in southern Ontario, Canada, was determined. Horses were categorized as thin (BCS=3/9; n = 6), moderate (BCS=4 or 5/9; n = 18), overweight (BCS=6 or 7/9; n = 19) or obese (BCS=8 or 9/9; n = 11). Total fat mass (kg) and body fat% was measured using mfBIA, lameness was assessed (AAEP lameness scale) and synovial fluid was collected via aseptic arthrocentesis from the left intercarpal joint for assessment of inflammatory biomarkers (PGE , GAG). Means were compared with a one-way ANOVA; correlation coefficients were calculated using a Spearman Rank Order Correlation to reveal correlations between variables. BCS was positively correlated with BW, FM, FP, AL and PL-PGE . BW was also significantly positively correlated with PL-PGE . It is concluded that BCS is significantly correlated with PL-PGE , due in part to the combined effect of AL and body condition. Net inflammatory effects of body fat on risk for joint disease require further study.

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Section: Discussionmentioning

confidence: 98%

Exploring relationships between body condition score, body fat, activity level and inflammatory biomarkers

Pearson

Wood

Stanley³

et al. 2018

Animal Physiology Nutrition

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“…Outra possível explicação para a diminuição da concentração de CK no GS seria a presença de vitamina E e de cromo no Tonnus JCR ® em pasta. Esses componentes participam no metabolismo energético reduzindo o estresse oxidativo e, consequentemente, o acúmulo das espécies reativas de oxigênio que se depositam na musculatura, podendo reduzir o dano muscular e melhorar a recuperação pós-exercício (Lindinger et al, 2017). Apesar dessa associação ser muito utilizada juntamente com o selênio, estudos apontam resultados poucos satisfatórios (Etchichury, 2004;Kienzle et al, 2006;Vieira et al, 2013).…”

Section: Discussionunclassified

Influência da suplementação nutricional sobre o metabolismo energético e enzimas musculares em cavalos de Team Penning

Tongu

Leite

Bizare

et al. 2018

Rev. Acad. Ciênc. Anim.

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O Team Penning (TP) é uma modalidade equestre que exige velocidade máxima. Nesse tipo de exercício ocorre o rápido consumo de energia pela via anaeróbica. Diversos suplementos têm sido desenvolvidos para melhorar o desempenho e diminuir lesões musculares em equinos atletas. Objetivou-se neste estudo avaliar a influência da suplementação com Tonnus JCR® nos parâmetros fisiológicos, metabolismo energético e muscular no treinamento de TP. Foram utilizados 12 equinos da raça Quarto de Milha, atletas de TP, separados em dois grupos, suplementado (GS) e não suplementado (GNS), avaliados em dois treinos. Foi realizado o exame físico, avaliação das concentrações plasmáticas de glicose e lactato, e concentrações séricas de creatinoquinase (CK), aspartato aminotransferase (AST) e lactato desidrogenase (LDH). As amostras de sangue foram colhidas durante e após os treinos em 12 diferentes momentos (M0 - M11). A suplementação foi realizada no intervalo entre os treinos. No segundo treino, verificou-se diminuição nas concentrações de glicose no GS quando comparado ao treino 1 (p = 0,01); no GNS não houve diferença entre os treinos (p = 0,13). Não houve diferença nas concentrações de lactato entre grupos e treinos. Os valores da concentração de CK no treino 1 não apresentaram diferença entre os grupos (p = 0,83) e momentos (p = 0,16). Quando comparadas as concentrações de CK entre os grupos no treino 2, observaram-se concentrações menores no GS (p = 0,02). Ao se comparar o GS antes e após a suplementação, as concentrações de CK foram menores no treino 2 (p = 0,01). No GNS não houve diferença entre os treinos (p = 0,51). As enzimas AST e LDH não diferiram entre os grupos nos treinos 1 e 2. Concluiu-se que a suplementação influenciou de forma positiva, diminuindo as concentrações de glicose e os níveis de CK, o que indica menor injúria muscular pós-treino.

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“…The cost:benefit ratio of joint supplements is questionable in the geriatric horse when owner resources are limited, preferring to concentrate on effective pain relief and quality farriery. If a supplement is desired, those combinations containing polyunsaturated fatty acids, such as omega 3 fatty acids, their derivatives and/or green lipped mussel extract, may be worthy of consideration (Manhart and others 2009, Cayzer and others 2012, Lindinger and others 2017, Murray and others 2017).…”

Section: Osteoarthritismentioning

confidence: 99%

Clinical care of the geriatric horse

Jarvis¹

2021

In Practice

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Background: Geriatric horses account for a significant proportion of the UK horse population and therefore age‐related conditions are commonly encountered in equine practice. Aim of the article: This review aims to provide an overview of the practical approach to managing osteoarthritis, pituitary pars intermedia dysfunction, dental disease, weight loss and nutrition and colic in geriatric horses.

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Effects of a Novel Dietary Supplement on Indices of Muscle Injury and Articular GAG Release in Horses

Cited by 5 publications

References 54 publications

Exploring relationships between body condition score, body fat, activity level and inflammatory biomarkers

Exploring relationships between body condition score, body fat, activity level and inflammatory biomarkers

Influência da suplementação nutricional sobre o metabolismo energético e enzimas musculares em cavalos de Team Penning

Clinical care of the geriatric horse

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