2011
DOI: 10.1590/s0103-64402011000200002
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Effects of a novel calcium aluminate cement on the early events of the progression of osteogenic cell cultures

Abstract: The present study evaluated the progression of osteogenic cell cultures exposed to a novel calcium aluminate cement (CAC+) in comparison with the gold standard mineral trioxide aggregate (MTA). Cells were enzimatically isolated from newborn rat calvarial bone, plated on glass coverslips containing either CAC+ or a control MTA samples in the center, and grown under standard osteogenic conditions. Over the 10-day culture period, roundening of sample edges was clearly noticed only for MTA group. Although both cem… Show more

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Cited by 37 publications
(41 citation statements)
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“…17,19 According to the results, the pulp cells seeded onto the BM presented faster proliferative capability at the initial periods, in comparison with those of the NC group. This rapid cell proliferation may be attributed to the BM composition, since it has been found that calcium-aluminate 15,19 and chitosan 35 increase the proliferation of cultured cells. Additionally, the RGD sequences in the collagen fibrils may have ο Indicates a significant difference for the NC group among the time points (two-way ANOVA; Tukey's test; p < 0.05).…”
Section: Discussionmentioning
confidence: 99%
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“…17,19 According to the results, the pulp cells seeded onto the BM presented faster proliferative capability at the initial periods, in comparison with those of the NC group. This rapid cell proliferation may be attributed to the BM composition, since it has been found that calcium-aluminate 15,19 and chitosan 35 increase the proliferation of cultured cells. Additionally, the RGD sequences in the collagen fibrils may have ο Indicates a significant difference for the NC group among the time points (two-way ANOVA; Tukey's test; p < 0.05).…”
Section: Discussionmentioning
confidence: 99%
“…10 It was previously demonstrated that calcium-aluminate is capable of inducing osteoblastic marker expression and mineralized matrix deposition in pre-osteoblast cells. 15,19 Moreover, an in vivo study conducted on rat's molars demonstrated that calcium-aluminate cement enhanced dentin bridge deposition after its application to mechanically exposed pulps. 39 One may conclude that the experimental chitosan/collagen biomembrane embedded with calcium-aluminate microparticles seems to be a very interesting candidate for direct pulp-capping therapy, since it was cytocompatible with human dental pulp cells, acting as a substrate for cell adhesion and proliferation, followed by high induction of odontoblastic phenotypes, and culminating in intense mineralized matrix deposition.…”
Section: Discussionmentioning
confidence: 99%
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“…Calcium aluminate-based cement (CAC) has already been studied for biomedical applications as endodontics [2][3][4][5][6] . This material presented good physical and mechanical properties 7 , biocompatibility 8,9 and acted as a chemical and mechanical barrier against bacterial microleakage 4 . This sort of cement has also shown an absence of inflammatory reaction and it was biocompatible when tested on rat subcutaneous tissue 2 .…”
Section: Introductionmentioning
confidence: 99%
“…MTA primarily consists of tricalcium silicate (3CaD.SiD 2 ), dicalcium silicate (2CaD.SiD 2 ) 4,5 as binder phases, and bismuth oxide to increase its radiopacity 1 . Calcium aluminate cement (CAC) has been studied as root-end filling material to overcome some MTA drawbacks such as the long setting time and its negative implications for the clinical needs [6][7][8][9][10][11][12] . CAC has suitable physical and mechanical properties 10 , biocompatibility 7,12 , ability of stimulating hydroxyapatite deposition in simulated body fluid solution 13 and acts as a barrier against bacterial microleakage 8 .…”
Section: Introductionmentioning
confidence: 99%