Effects of a non-steroidal anti-inflammatory drug on delayed onset muscle soreness and indices of damage.

Abstract

Twenty untrained male volunteers were required to run downhill for 45 minutes on a motor driven treadmill to induce muscle soreness. The volunteers took diclofenac or placebo before and for 72 hours after two runs 10 weeks apart, in a randomised double blind crossover design. Subjective soreness was assessed before and at intervals up to 72 hours after each run; venous blood samples, collected at the same time intervals, were used to estimate serum activities of creatine kinase, lactate dehydrogenase and aspartate aminotransferase and serum concentrations of creatinine and urea. Subjective soreness and the biochemical parameters increased after both runs, although the serum enzyme response to the second run was reduced. Diclofenac had no influence on the serum biochemical response to downhill running. Although overall soreness was not affected by diclofenac, individual soreness measurements were reduced by diclofenac at the first period of the study. These results suggest that diclofenac does not influence muscle damage, but may slightly reduce the associated soreness.

Effects of Differing Dosages of Pomegranate Juice Supplementation after Eccentric Exercise

“…Pomegranate polyphenols contain an abundance of antioxidant and anti-inflammatory properties [21]; thus, a potential mechanism for the improved strength recovery observed in PJC supplementation groups may be due to attenuated oxidative stress or inflammation at some point during the postexercise time period. However, it must be stated that this may not be the case, as studies that have investigated the effects of antioxidant or antiinflammatory supplementation on strength recovery after eccentric exercise have demonstrated equivocal findings [5][6][7][8][9][10][11][12][13][14][15]. Indeed, some studies have shown a beneficial effect of antioxidant supplementation at lower dosages [11,12], while, at higher dosages, others have shown no effect [7] or detrimental effects [9].…”

“…Antioxidant and nonsteroidal antiinflammatory drugs (NSAIDs) have a negligible effect on strength recovery [5][6][7][8][9][10][11][12][13]. On the contrary, NSAID [10] and vitamin C [14,15] supplementation have been shown to alleviate muscle soreness.…”

“…Antioxidant and nonsteroidal antiinflammatory drugs (NSAIDs) have a negligible effect on strength recovery [5][6][7][8][9][10][11][12][13]. On the contrary, NSAID [10] and vitamin C [14,15] supplementation have been shown to alleviate muscle soreness. Dietary supplementation with polyphenols, a class of antioxidant and anti-inflammatory phytonutrients [21], has been demonstrated to improve muscular strength recovery after eccentric exercise in humans [4,[16][17][18][19][20].…”

“…A goal of numerous studies has been to identify dietary supplements that accelerate recovery from a bout of intense eccentric exercise [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Antioxidant and nonsteroidal antiinflammatory drugs (NSAIDs) have a negligible effect on strength recovery [5][6][7][8][9][10][11][12][13].…”

Untersuchung der entzündlichen Komponente von Muskelschmerz nach exzentrischer Belastung bei jüngeren und älteren Erwachsenen.

“…B. "Bergablaufen" (Donnelly et al 1988, Donnelly et al 1990) und "Sprünge in die Tiefe" (Semark et al 1999 Belastung sogar verzögern könnten (Seidel et al 2012). …”