Effects of a Mediterranean diet on the development of diabetic complications: A longitudinal study from the nationwide diabetes report of the National Program for Prevention and Control of Diabetes (NPPCD 2016-2020)

Ghaemi, Fatemeh; Firouzabadi, Fatemeh Dehghani; Moosaie, Fatemeh; Shadnoush, Mahdi; Poopak, Amirhossein; Kermanchi, Jamshid; Abhari, Seyede Marzie Fatemi; Forouzanfar, Reza; Mansournia, Mohammad Alì; Khosravi, Ahmad; Mohajer, Bahram; Ramandi, Mohammad Mostafa Ansari; Nakhjavani, Manouchehr; Esteghamati, Alireza

doi:10.1016/j.maturitas.2021.08.003

Cited by 31 publications

(36 citation statements)

References 54 publications

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“…The type of fat intake may affect diabetes complications [ 12 ], so trials and observational studies should consider intake of specific parent fatty acids (e.g., EPA, DHA, AA) in examining dietary effects on diabetes complications. The Mediterranean diet, which is high in unsaturated fats and nitrogen-rich vegetables, has been associated with the production of nitrolipid species which inhibited sEH to reduce blood pressure [ 91 , 92 ]. Additional studies are needed to investigate whether the Mediterranean diet may confer similar benefits on the development of diabetic complications via oxylipins.…”

Section: Synthesis and Clinical Translationmentioning

confidence: 99%

Soluble Epoxide Hydrolase and Diabetes Complications

Anita

Swardfager

2022

IJMS

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Type 2 diabetes mellitus (T2DM) can result in microvascular complications such as neuropathy, retinopathy, nephropathy, and cerebral small vessel disease, and contribute to macrovascular complications, such as heart failure, peripheral arterial disease, and large vessel stroke. T2DM also increases the risks of depression and dementia for reasons that remain largely unclear. Perturbations in the cytochrome P450-soluble epoxide hydrolase (CYP-sEH) pathway have been implicated in each of these diabetes complications. Here we review evidence from the clinical and animal literature suggesting the involvement of the CYP-sEH pathway in T2DM complications across organ systems, and highlight possible mechanisms (e.g., inflammation, fibrosis, mitochondrial function, endoplasmic reticulum stress, the unfolded protein response and autophagy) that may be relevant to the therapeutic potential of the pathway. These mechanisms may be broadly relevant to understanding, preventing and treating microvascular complications affecting the brain and other organ systems in T2DM.

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Section: Synthesis and Clinical Translationmentioning

confidence: 99%

Soluble Epoxide Hydrolase and Diabetes Complications

Anita

Swardfager

2022

IJMS

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“…With 22 questions, the CIRS (16) examines the following: personal support (3 questions with a score range of 3-15), friends/family/environment (7 questions with a score range of 7-35), policies/media (3 questions with a score range of 3-15), health-related organizations (3 questions with a score range of [3][4][5][6][7][8][9][10][11][12][13][14][15], workplace support (3 questions with a score range of 3-15), health-related providers (3 questions with a score range of 3-15), health-related organizations (3 questions with a score range of [3][4][5][6][7][8][9][10][11][12][13][14][15], and health-related providers (3 questions with a score range of [3][4][5][6][7][8][9][10][11][12][13][14][15]. The questionnaire's Cronbach's alpha was 0.81 in the Nowruz study (17).…”

Section: Chronic Illness Resources Surveymentioning

confidence: 99%

“…According to the WHO's six divisions, Iran is a member of the Eastern Mediterranean region, which ranks third among the 22 member nations in the number of people aged 20-79 who have diabetes. In Iran, 32,414 people died as a result of the disease's consequences in 2017 (4). Internal emergencies at the hospital include uncontrolled, early, and late consequences of type 2 diabetes.…”

Section: Introductionmentioning

confidence: 99%

Determining the Predictors of Self-Management Behaviors in Patients With Type 2 Diabetes: An Application of Socio-Ecological Approach

Soola

Davari

Moghaddam

2022

Front. Public Health

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BackgroundType 2 diabetes complications are responsible for 2% of hospital emergency visits. Self-management practices are one of the most essential approaches to control type 2 diabetes. The goal of this study was to use an ecological approach to investigate the predictors of self-management behaviors in diabetes patients referred to the emergency department in Ardabil in 2020.MethodsIn this cross-sectional study, 273 individuals with type 2 diabetes who were sent to the emergency department of Imam Khomeini Educational and Medical Center in Ardabil were included using the available sample method. Demographic information questionnaires, including the Diabetes Distress Screening Tool (DDS2), General Diabetes Knowledge (DKT2), Diabetes Empowerment Questionnaire (DES-SF), Patient Health Questionnaire 9 (PHQ 9), Beliefs to Treatment Effectiveness Scale (BTES), Diabetes Self-Efficacy Scale (DSES), Chronic Illness Resources Survey (CIRS), Situational Effects Questionnaire, and Diabetes self-management support (DSMS), were all used to collect data. The independent t-test, one-way ANOVA, Pearson correlation coefficient, and multiple regression were used to analyze the data.ResultsThe results of the study showed that in the framework of ecological approach, predictors of self-management behaviors at the four levels are as follows: at the individual level—gender (p = 0.025), education (p = 0.002), duration of diabetes (p = 0.38), having a glucometer at home (p < 0.001), diabetes empowerment (p < 0.001), personal support (p = 0.002), and self-efficacy (p = 0.047); at the interpersonal level—the main health support (p < 0.001), membership in social networks (p < 0.005), family/friends support (p < 0.001), and neighborhoods support (p < 0.001); at the group and organizational level—organizational support (p = 0.013); at the community and policy level—the impact of mass media in health (p < 0.001) and situational influence (p < 0.001).ConclusionThe impact of non-individual levels, such as the environment, on a person's decision to manage diabetes is crucial. Diabetes management necessitates a significant amount of effort, which involves maintaining the health of diabetes patients and the community while also minimizing emergency department workload.

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“…1 Hyperglycemia is the most important characteristic of T2DM, leading to a lot of diabetic complications, like retinopathy, cardiovascular diseases, neuropathy, and diabetic foot. 2 Multiple factors also contribute to diabetes-associated hyperglycemia, such as insulin resistance, oxidative stress, leaky gut, chronic low-grade inflammation, and gut microflora dysbiosis. 3 Hyperglycemia, in turn, can make these factors worse.…”

Section: Introductionmentioning

confidence: 99%