Effects of a meal replacement system alone or in combination with phentermine on weight loss and food cravings

Moldovan, Christina; Weldon, Abby J.; Daher, Noha; Schneider, Louise E.; Bellinger, Denise L.; Berk, Lee; Hermé, Alyson C.; Aréchiga, Adam L.; Davis, Willie; Peters, Warren

doi:10.1002/oby.21649

Cited by 40 publications

(26 citation statements)

References 36 publications

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“…The drug stimulates primarily the release of norepinephrine, but to lower extent also dopamine and serotonine. Depending on the dose (which is typically between 30 and 37.5 mg/d) the placebo-subtracted weight loss attributed to treatment with phentermine (30 mg/d) is in the range of 4-8 kg after 12 weeks of treatment (Kim et al, 2006;Kang et al, 2010;Moldovan et al, 2016). Phentermine is generally well tolerated with little to no abusive potential, even when used chronically for up to 21 years (Hendricks et al, 2009).…”

Section: B 24-dinitrophenolmentioning

confidence: 99%

Anti-Obesity Therapy: from Rainbow Pills to Polyagonists

et al. 2018

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Section: B 24-dinitrophenolmentioning

confidence: 99%

Anti-Obesity Therapy: from Rainbow Pills to Polyagonists

et al. 2018

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“…JumpstartMD weight losses were compared to those reported for other commercial programs (Weight Watchers [6,8,[11][12][13][14][31][32][33][34][35][36][37][38][39][40][41][42], Slimming World [12, 13, 15-22, 37, 43], Rosemary Conley [12,13,37,42], Biggest Losers Club [25,44,45], eDiet [46,47], Jenny Craig [23,24,33,[48][49][50], Itrim [26], Nutrisystem [9,33,[51][52][53], Medifast [28,29,[54][55][56], Health Management Resources [30,[57][58][59], Metabolic Balance Nutrition Program [27], and D...…”

Section: Comparison With Other Published Studiesmentioning

confidence: 99%

“…With one notable exception, the comparative analyses of Table 3 show that JumpstartMD patients lost greater weight than reported for other calorie-counting, food choice, and meal plans (Weight Watchers, Slimming World, Rosemary Conley, and Itrim). JumpstartMD kg weight loss was 53% greater at 12-13 weeks, 84% greater at 24-26 weeks, and 75% Meffert [27] Meffert [27] Meffert [27] Meffert [27] Collins [44] Collins [44] Collins [45] Collins [45] Collins [45] Collins [45] Gold [46] Gold [46] Baetge [33] Rock [50] Rock [49] Rock [49] Rock [50] Rock [49] Rock [49] Baetge [33] Foster [52] Figueroa [53] Moldovan [55] Coleman [28] Davis [54] Shikany [56] Coleman [28] Davis [54] Shikany [56] Coleman [29] Coleman [29] Smith [59] Smith [59] Donnelly [58] Donnelly [58] Furlow [30] Donnelly [58] Donnelly [58] Furlow [30] Fabricatore [51] Fabricatore [51] greater at 1 year than reported for other commercial caloriecounting programs for LOCF analyses and approximately 2fold greater...…”

Section: Itrimmentioning

confidence: 99%

Effect of JumpstartMD, a Commercial Low-Calorie Low-Carbohydrate Physician-Supervised Weight Loss Program, on 22,407 Adults

Bourke¹,

Morton

Williams³

2020

Journal of Obesity

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Background. Commercial weight loss programs provide valuable consumer options for those desiring support. Several commercial programs are reported to produce ≥3-fold greater weight loss than self-directed dieting. The effectiveness of JumpstartMD, a commercial pay-as-you-go program that emphasizes a low-to-very-low-carbohydrate real-food diet and optional pharmacologic treatment without prepackaged meals or meal replacement, has not previously been described. Methods. Completer and last observation carried forward (LOCF) of clinic-measured weight loss (kg) in 18,769 female and 3638 male JumpstartMD participants. Results. Completers lost (mean ± SE) 8.7 ± 0.04 kg, 9.5 ± 0.04% with 44.5 ± 0.5% achieving ≥10% weight loss at 3 months (mo, N = 14,999 completers); 11.8 ± 0.1 kg, 12.6 ± 0.1% with 66.4 ± 0.6% achieving ≥10% weight loss at 6 mo (N = 11,805); and 11.5 ± 0.2 kg, 12.0 ± 0.2% with 57.6 ± 0.9% achieving ≥10% weight loss at 12 mo (N = 8514). LOCF estimates were −6.5 ± 0.03 kg, −7.2 ± 0.03% with 27.1 ± 0.3% achieving ≥10% weight loss at 3 mo; −7.7 ± 0.04 kg, −8.5 ± 0.04% with 36.3 ± 0.3% achieving ≥10% weight loss at 6 mo; and −7.7 ± 0.1 kg, −8.4 ± 0.1% with 34.6 ± 0.3% achieving ≥10% weight loss after 12 mo. Frequent health coach meetings was a major determinant of weight loss, with women and men attending ≥75% of their weekly appointments losing 8.8 ± 0.04 and 11.9 ± 0.1 kg, respectively, after 3 mo, 13.1 ± 0.1 and 16.5 ± 0.3 kg after 6 mo, and 16.5 ± 0.3 and 19.4 ± 0.8 kg after 12 mo. Phentermine and phendimetrazine had a minor effect in women only at 1 (6.1% greater weight loss than untreated), 2 (4.1%), and 3 mo (1.2%), but treated patients showed longer enrollment than nontreated during the first 3 (females: +0.4 ± 0.01; males: +0.3 ± 0.04 mo), 6 (females: +1.1 ± 0.04; males: +1.0 ± 0.1 mo), and 12 mo (females: +2.7 ± 0.1; males: +2.4 ± 0.2 mo). JumpstartMD produced generally greater weight loss than published reports for other real-food and prepackaged-meal commercial programs and somewhat greater or comparable losses to meal replacement diets. Conclusion. A one-on-one medically supervised program that emphasized real low-carbohydrate foods produced effective weight loss, particularly in those attending ≥75% of their weekly appointments.

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“…Based on the studies included in the metaanalysis, the most frequent adverse drug reaction of phentermine was dry mouth and insomnia, and the incidence of the adverse reactions showed a significant increase in phentermine compared with placebo [22,[30][31][32][33][34]. In addition, cardiovascular and neurological symptoms, such as hypertension, nervousness, depression, and palpitation, were reported [22,30,[35][36][37].…”

Section: Journal Of Health Informatics and Statisticsmentioning

confidence: 99%

Meta-analysis of Change in Weight and Heart Rate for Phentermine in Obesity

Woo¹,

Jeong²

2018

J Health Info Stat

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Obesity is defined as a body mass index (BMI) of ≥ 30 kg/m 2 [1]. In Korea, obesity is defined as BMI of 25 kg/m 2 based on the WHO Asia-Pacific perspective for Asians [2,3]. The prevalence of obesity defined by BMI >25 kg/m 2 was increased from 36.2% in 2011 to 38.9% in 2016. The prevalence rate of obesity has also been > 60% in America from 2012 [4]. Obesity needs to be considered as chronic disease [5]. It was relevant to cardiovascular diseases [6], and a report showed that approximately 40% of the mortality rate in the U.S. was due to obesity or obesity-related diseases in 2000 [7]. To reduce body weight, a weight control program that includes a dietary therapy and exercise therapy needs to be tried [8], and an appetite suppressant has been generally prescribed for obesity care [9].

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Effects of a meal replacement system alone or in combination with phentermine on weight loss and food cravings

Abstract: Both phentermine combined with a meal replacement program and meal replacements alone significantly reduced body weight and food cravings; however, the addition of phentermine enhanced these effects.

Cited by 40 publications

References 36 publications

Anti-Obesity Therapy: from Rainbow Pills to Polyagonists

Anti-Obesity Therapy: from Rainbow Pills to Polyagonists

Effect of JumpstartMD, a Commercial Low-Calorie Low-Carbohydrate Physician-Supervised Weight Loss Program, on 22,407 Adults

Meta-analysis of Change in Weight and Heart Rate for Phentermine in Obesity

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