Effects of a Maximal Graded Exercise Test on Glutathione as a Marker of Acute Oxidative Stress

Elokda, Ahmed; Shields, Richard K.; Nielsen, David H.

doi:10.1097/00008483-200507000-00007

Cited by 29 publications

(46 citation statements)

References 11 publications

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“…The authors suggested that the low-intensity exercise may fall below the threshold needed for improvement while the improvement in highintensity exercise may have been abolished by free radicals generated at high intensities [34]. Although the TAC remained unchanged following the intervention in the exercise group compared with the control group, this would not necessarily reflect the acute increase in oxidative stress associated with a single exercise bout [35].…”

Section: Discussionmentioning

confidence: 99%

Six months of aerobic exercise does not improve microvascular function in type 2 diabetes mellitus

et al. 2006

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Aims/hypothesis Adults with type 2 diabetes mellitus have impaired microvascular function. It has been hypothesised that microvascular function may be restored through regular exercise. The aim of this study was to investigate whether 6 months of regular aerobic exercise would improve microvascular function in adults with type 2 diabetes. Materials and methods Fifty-nine patients with type 2 diabetes (32 males, age 62.9±7.6 years, HbA 1c 6.8±0.9%) were randomised to either a 6-month aerobic exercise programme (30 min, three times a week, 70-80% of maximal heart rate) or a 'standard care' control group. Before and after the intervention period, microvascular function was assessed as the maximum skin hyperaemia to local heating and endothelial and non-endothelial responsiveness following the iontophoretic application of acetylcholine and sodium nitroprusside. Maximal oxygen uptake, as an index of aerobic fitness, was assessed using a maximal exercise test.

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Section: Discussionmentioning

confidence: 99%

Six months of aerobic exercise does not improve microvascular function in type 2 diabetes mellitus

et al. 2006

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“…When free radical formation is not excessive, the body is able to maintain the resting intracellular levels of GSH and GSSG by reducing GSSG back to GSH [15]. Under strenuous exercise conditions there is an increase in free radical production causing GSSG creation, which exceeds GSH supply and uptake [16][17][18][19]. The GSH:GSSG ratio, which reflects this imbalance, has become a sensitive biomarker of the reduction-oxidation (redox) status [13,16,17].…”

Section: Introductionmentioning

confidence: 99%

“…The GSH:GSSG ratio, which reflects this imbalance, has become a sensitive biomarker of the reduction-oxidation (redox) status [13,16,17]. Decreases in the GSH:GSSG ratio have been interpreted as a sign of oxidative stress [17].…”

Section: Introductionmentioning

confidence: 99%

Effects of exercise induced oxidative stress on glutathione levels in Parkinson’s disease on and off medication

et al. 2010

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Resting plasma glutathione (GSH) levels are lower in individuals with Parkinson's disease (PD) than any other neurological condition. Medications used to treat PD have also been shown to further decrease this depletion. Acute exercise has been shown to be an effective tool to produce oxidative stress in other populations as reflected in lowering levels of GSH. The purpose of this study was to determine how PD responds to acute exercise stress and how medication affects these responses. Fourteen men with PD and 14 men without PD underwent an exercise stress test. Subjects with PD performed the test once off PD medication (PD-Off-med) for 12 h then again 1 week later on PD medication (PD-On-med). GSH and glutathione disulfide (GSSG), were collected via blood draws at rest and after peak exercise along with peak VO(2). At rest and at peak exercise GSH levels and the GSH:GSSG ratio were significantly lower in the PD-On-med and PD-Off-med as compared to controls. GSSG levels were significantly higher in both medication conditions at rest and peak exercise compared to controls. When comparing PD-On-med vs. PD-Off-med at rest and peak exercise, the PD-On-med had lower GSH levels, a lower GSH:GSSG ratio and higher GSSG levels. VO(2) correlated positively with GSH levels. Subjects with PD have lower plasma GSH levels than healthy controls at rest and at peak exercise.

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“…Although there are a few studies reporting the effects of treadmill exercise on redox state in football players or non-athletes [1,[33][34][35][36][37], the most adequate comparison of our results is with studies performed on young handball players [4,5,31], although the exercise test performed in these studies was cycling ergometer testing. However, because it has been shown that endogenous oestrogen may have a protective role in exercise-induced oxidative stress among female handball players [38] and female non-ath- exercise load and consequently longer duration of the exercise test.…”

Section: Statisticsmentioning

confidence: 99%

The redox state of young female handball players following acute exercise and a one-month precompetitive training period

Pušica¹,

Valdevit²,

Todorović³

et al. 2013

Ser J Exp Clin Res

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Effects of a Maximal Graded Exercise Test on Glutathione as a Marker of Acute Oxidative Stress

Cited by 29 publications

References 11 publications

Six months of aerobic exercise does not improve microvascular function in type 2 diabetes mellitus

Six months of aerobic exercise does not improve microvascular function in type 2 diabetes mellitus

Effects of exercise induced oxidative stress on glutathione levels in Parkinson’s disease on and off medication

The redox state of young female handball players following acute exercise and a one-month precompetitive training period

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