Effects of a Low‐Fat Diet on the Anti‐inflammatory Interleukin Levels of Older Adults

Abstract

Immunosenescence involves changes on the cellular and molecular levels of the immune system, and is associated with aging. Higher incidence of autoimmune disorders and other inflammatory conditions, as well as increased rates of infectious disease, cancer, and mortality have been linked to this condition. Proinflammatory interleukins (IL‐6) have been shown to increase with age, while anti‐inflammatory interleukins (IL‐4, IL‐10) decrease. Additionally, a low‐fat diet has been correlated with lower IL‐6 levels in older adults. The purpose of this study was to examine the effects of fat intake on IL‐4 and IL‐10 levels in older adults.IL‐4 and IL‐10 concentrations were analyzed from venous samples of 10 older adults (46–85 yrs) and compared to venous samples of 9 younger adults (18–45 yrs). Five older adults were counseled to consume a high‐carbohydrate, low‐fat diet for three days prior. All other subjects were instructed to consume their normal diet. Contrary to our hypothesis, a low‐fat diet did not result in increased levels of IL‐4 or IL‐10 levels, and no reversal of immunosenescence. Further investigation is warranted to investigate contributing factors to changes in immunosenescence. This research was supported by the East Carolina University Division of Research and Graduate Studies.