Effects of a Lifestyle Program on Vascular Reactivity in Macro- and Microcirculation in Severely Obese Adolescents

Montero, David; Walther, Guillaume; Perez-Martin, Antonia; Mercier, Charles S.; Gayrard, Sandrine; Vicente-Salar, Néstor; Sempere-Ortells, José M.; Martínez-Peinado, Pascual; Roche, Enrique; Vinet, Agnès

doi:10.1210/jc.2013-3394

Cited by 18 publications

(19 citation statements)

References 40 publications

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“…In our study, the population of patients with obesity displayed a slight impaired endothelium‐dependent vasodilatation compared with our previous report . However, the mild endothelial dysfunction found in our population of patients with obesity could be explained by the fact that the population of women was young (mean, 21 years), as Montero et al reported an absence of endothelium‐dependent vasorelaxation in young participants with obesity .…”

Section: Discussioncontrasting

confidence: 61%

Microparticle miRNAs as Biomarkers of Vascular Function and Inflammation Response to Aerobic Exercise in Obesity?

Dimassi

Karkeni

Laurant

et al. 2018

Obesity

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Objective This study aimed to explore the role of nine microRNAs (miRNAs) in microparticles (MPs) on the efficacy of aerobic exercise in the regulation of inflammation and vascular function in obesity. Methods Sedentary women with normal weight (n = 6, BMI < 25 kg/m2) and women with obesity (n = 9, BMI > 30 kg/m2) were recruited at F. Hached Hospital (Sousse, Tunisia) and enrolled in an 8‐week aerobic program. Vascular function was assessed using laser Doppler flowmetry/iontophoresis, circulating MPs by flow cytometry, miRNAs by real‐time polymerase chain reaction, and inflammation by ELISA, before and after exercise. Results Women with obesity presented with high prevalence of cardiovascular risk factors and a higher circulating MP level compared with healthy subjects. The MP miRNA profile was significantly different in the two groups. Exercise reduced BMI and inflammation in both groups and significantly improved endothelial‐dependent response (acetylcholine cutaneous vascular conductance) for healthy subjects, with a trend for women with obesity. Circulating MP level was increased after exercise, and miRNA expression was differentially modulated in both populations. Pearson analysis revealed a correlation between MPs miR‐124a and miR150 and adiponectin, TNFα, or IL‐6 levels. Conclusions The relation between MPs and miRNA profile, inflammation, vascular function, and exercise is of particular interest for defining “miRNA biomarker signature” in patients with cardiovascular disease who are potentially susceptible to respond to exercise.

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Section: Discussioncontrasting

confidence: 61%

Microparticle miRNAs as Biomarkers of Vascular Function and Inflammation Response to Aerobic Exercise in Obesity?

Dimassi

Karkeni

Laurant

et al. 2018

Obesity

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“…Although Endo-PAT was initially set forth as an alternative technique for FMD, a large population-based study recently pointed out that micro-(measured with Endo-PAT) and macrovascular (detected with FMD) endothelial dysfunctions can develop independently of each other (66). Microvascular endothelial dysfunction would precede endothelial dysfunction at the macrovascular level in obese children (12). To conclude, …”

Section: Technological Advancements In Obesity-associated Endothelialmentioning

confidence: 98%

“…Endothelial micro particles (EMP) (12,13) as well as endothelial progenitor cells (EPC) (14) and circulating angiogenic cells (CAC) (15) emerged as markers of respectively endothelial damage and repair. All have been implicated in the process of childhood obesity-related endothelial dysfunction (16,17).…”

Section: Introductionmentioning

confidence: 99%

Childhood obesity–related endothelial dysfunction: an update on pathophysiological mechanisms and diagnostic advancements

et al. 2016

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“…8 However, whether lifestyle interventions are also capable of reversing endothelial dysfunction at the microvascular level is currently not clear. 9 In recent decades, novel insights have been obtained into the mechanistic basis for endothelial homeostasis. First, endothelial progenitor cells (EPCs) were recognized as important contributors of endothelial repair 10 because they are able to replace lost endothelial cells.…”

Section: What This Study Addsmentioning

confidence: 99%

Diet, Exercise, and Endothelial Function in Obese Adolescents

Bruyndonckx

Hoymans

Guchtenaere³

et al. 2015

Pediatrics

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BACKGROUND AND OBJECTIVES: Endothelial dysfunction is the first, although reversible, sign of atherosclerosis and is present in obese adolescents. The primary end point of this study was to investigate the influence of a multicomponent treatment on microvascular function. Additional objectives and end points were a reduced BMI SD score, improvements in body composition, exercise capacity, and cardiovascular risk factors, an increase in endothelial progenitor cells (EPCs), and a decrease in endothelial microparticles (EMPs).

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Effects of a Lifestyle Program on Vascular Reactivity in Macro- and Microcirculation in Severely Obese Adolescents

Cited by 18 publications

References 40 publications

Microparticle miRNAs as Biomarkers of Vascular Function and Inflammation Response to Aerobic Exercise in Obesity?

Microparticle miRNAs as Biomarkers of Vascular Function and Inflammation Response to Aerobic Exercise in Obesity?

Childhood obesity–related endothelial dysfunction: an update on pathophysiological mechanisms and diagnostic advancements

Diet, Exercise, and Endothelial Function in Obese Adolescents

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