Effects of a lifestyle intervention on the biomarkers of oxidative stress in non-communicable diseases: A systematic review

Abstract

Oxidative stress plays a critical role in the pathogenesis of chronic diseases. Therefore, improvement of oxidative stress status through lifestyle intervention can play a vital role in preventing and treating chronic diseases. This systematic review aims to provide an overview of articles published in the last decade examining the association between lifestyle intervention and oxidative stress biomarkers in the context of non-communicable diseases. The electronic databases PubMed and Web of Science were searched for relevant studies, following the PRISMA (Preferred Reporting of Systematic Reviews and Meta-Analyses) guidelines. This systematic review focused on the four important oxidative stress biomarkers; glutathione (GSH), superoxide dismutase (SOD), catalase, and malondialdehyde. 671 articles were identified, of which nine met the inclusion criteria. A trend emerged, showing that lifestyle modifications that focus on diet and physical health can improve oxidative stress in the form of an increase in superoxide dismutase and CAT levels and a decrease in Malondialdehyde levels in participants with non-communicable diseases (NCDs), GSH levels were not affected. However, the results are difficult to compare because of the heterogeneity of the methods of the biomarkers studied. Our review indicates that oxidative stress can be influenced by lifestyle modifications and may be an effective tool for the prevention and management of non-communicable diseases. This review also elucidated the importance of analyzing multiple oxidative stress biomarkers to evaluate oxidative stress, it further highlights the need to conduct long-term lifestyle intervention studies on oxidative stress biomarkers to understand the connection between oxidative stress biomarkers, NCDs and Lifestyle intervention.

Plasma Redox Balance in Advanced Maternal Age Pregnant Women and Effects of Plasma on Umbilical Cord Mesenchymal Stem Cells

“…Instead, in all conditions in which the systems for regulating the balance between oxidants and antioxidants are poorly effective, the development of oxidative stress is markedly greater. Certainly one of those conditions predisposing the onset of oxidative stress is aging [24].…”

Untargeted metabolomics analysis reveals the metabolic disturbances and exacerbation of oxidative stress in recurrent spontaneous abortion

“…The use of antioxidants is widely studied as a potential treatment, such as vitamin C, vitamin E and dopamine [ 47 ]. In addition, the degree of oxidative stress can also be reduced by improving lifestyle, such as reducing exposure to oxidative stressors [ 48 ].…”

The Impact of Physical Exercise on Oxidative and Nitrosative Stress: Balancing the Benefits and Risks

“…Additionally, gender differences, often influenced by hormonal variations like estrogen in women, may necessitate adjustments in exercise intensities or modalities to optimize health outcomes across genders [86]. Individuals with chronic conditions need specially tailored exercise plans to avoid exacerbating oxidative stress, while ethnic and socioeconomic disparities can impact susceptibility to oxidative damage and access to necessary resources, highlighting the importance of public health initiatives aimed at providing equitable health opportunities [87][88][89]. Future research should employ longitudinal studies and personalized medicine principles to thoroughly investigate these demographic distinctions, thereby improving our ability to tailor exercise and dietary interventions to optimize individual health outcomes.…”