Effects of a Leucine and Pyridoxine-Containing Nutraceutical on Fat Oxidation, and Oxidative and Inflammatory Stress in Overweight and Obese Subjects

Zemel, Michael B.; Bruckbauer, Antje

doi:10.3390/nu4060529

Cited by 59 publications

(76 citation statements)

References 37 publications

(50 reference statements)

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“…Criteria for a valid measurement was a minimum of 15 min of steady state, with steady state determined as less than 10% fluctuation in minute ventilation and oxygen consumption and less than 5% fluctuation in RQ. RQ was calculated as CO 2 production/O 2 consumption [16]. …”

Section: Methodsmentioning

confidence: 99%

Fat utilization and arterial hypertension in overweight/obese subjects

et al. 2013

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BackgroundThe Respiratory Quotient is a parameter reflecting the utilization of the nutrients by a subject. It is associated with an high rate of subsequent weight gain and with the atherosclerosis. Subjects tending to burn less fat have an increased Respiratory Quotient. Aim of this study was to investigate on the relationship between the Respiratory Quotient and the cardiovascular risk factors.MethodsIn this cross-sectional study we enrolled 223 individuals of both sexes aged 45–75 ys that were weight stable, receiving a balanced diet, and not affected by debilitating disease or cardiovascular disease. The Respiratory Quotient was measured by Indirect Calorimetry. The measurement of the Blood Pressure was obtained by a mercury sphygmomanometer.ResultsWe enrolled 133 female and 90 male. Systolic blood pressure only was positively correlated to the Respiratory Quotient in univariate and multivariate regression analysis (p=0,017). The prevalence of hypertension was significatively different between the quartiles of the Respiratory Quotient, with the highest prevalence in the IV quartile (p=0,024).ConclusionHigh value of the Respiratory Quotient, an index of nutrients utilization, is associated to an high prevalence of Hypertension. It is possible that in the subjects with high Respiratory Quotient and high body mass index, the activation of the renin angiotensin system, in concert to the reduction of the utilization of the endogenous fat stores, could increase the risk of hypertension.

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Section: Methodsmentioning

confidence: 99%

Fat utilization and arterial hypertension in overweight/obese subjects

et al. 2013

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“…We have also recently shown leucine to interact synergistically with vitamin B6 to attenuate adiposity8 Pyridoxal phosphate inhibits adipocyte Ca 2+ influx in vitro,8 resulting in significant decreases in adipocyte fatty acid synthase expression and activity and corresponding reductions in adipocyte triglyceride content,8 because Ca 2+ signaling coordinately stimulates fatty acid synthase activity and inhibits lipolysis in adipocytes 9–13. Moreover, leucine and pyridoxal phosphate synergistically inhibit adipocyte triglyceride accumulation 8.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, leucine and pyridoxal phosphate synergistically inhibit adipocyte triglyceride accumulation 8. Consequently, the efficacy of a leucine (2.25 g/day)-B6 (30 mg pyridoxine/day) combination in stimulating fat oxidation in vivo was evaluated in a 28-day, placebo-controlled, randomized clinical trial with overweight and obese subjects and found to increase whole-body fat oxidation significantly by >30 g/day 8. However, this trial was of too short a duration to determine the efficacy of this combination in modulating body weight and composition.…”

Section: Introductionmentioning

confidence: 99%

Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects

Bruckbauer¹

2013

DMSO

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BackgroundWe recently demonstrated leucine to modulate energy partitioning between adipose tissue and muscle. Further, leucine exhibits a synergy with B6, resulting in reduced adipocyte lipid storage coupled with increased muscle fat oxidation. Accordingly, a nutraceutical (NuShape™) containing 2.25 g leucine and 30 mg B6 increased fat oxidation by >30 g/day in a 28-day randomized controlled trial. The present study evaluated the long-term efficacy of this combination in modulating body weight and composition.MethodsTwo 24-week, placebo-controlled, randomized trials, one with weight maintenance (n = 20) and one hypocaloric (−500 kcal/day; n = 24), were conducted using the nutraceutical Nushape in obese subjects.ResultsThe supplement resulted in fat loss in the maintenance study (−1.12 ± 0.36 and −1.82 ± 0.70 kg at 12 and 24 weeks, P < 0.01 versus placebo) while no change was found in the placebo group. In the hypocaloric study, the supplement group lost up to twice as much weight (6.18 ± 1.02 versus 3.40 ± 0.81 kg at 12 weeks and 8.15 ± 1.33 versus 5.25 ± 1.13 kg at 24 weeks, P < 0.01) and fat (4.96 ± 0.61 versus 2.31 ± 0.53 kg at 12 weeks and 7.00 ± 0.95 versus 4.22 ± 0.74 kg at 24 weeks, P < 0.01) than the placebo group.ConclusionThis nutraceutical combination results in significant fat loss in the absence of caloric restriction and markedly enhances weight and fat loss by 50%–80% over a 24-week period.

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“…Nutraceutical supplementation (leucine and pyridoxine), provides effective antioxidant and antiinflammatory influences, enhances fat oxidation and improves insulin signaling. 95,96 …”

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confidence: 99%

Role of Oxidative Stress and Associated Alteration in Enzyme Activities in Obesity Comorbidities

Demerdash¹

2017

Obes Res Open J

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Citation Review ABSTRACTObesity is defined as having a body mass index (BMI) of 30 kg/m 2 or above, with progressively increasing prevalence all over the world in recent years. Obesity is characterized by deposition of abnormally increased body fat, resulting from increased energy intake relative to energy expenditure. The condition is associated with several comorbidities that upsurge risk of morbidity. The purpose of this review is to describe the role of oxidative stress in release of pro-inflammatory mediators that influence fat and glucose metabolism and is associated with altered enzyme activity, which results in insulin resistance and other associated comorbidities. The main pathology is through intensified generation of reactive oxygen species (ROS) and diminution of antioxidant defense, creating a chronic inflammatory situation that is critically important in development of comorbidities. New strategies to combat resultant comorbidities concentrate on weight reduction either solely or coupled with moderately regular exercise. This policy may be sufficient to improve insulin sensitivity, regulate fatty acid metabolism together with refining antioxidant defense of the body. Other approaches encourage modulation of dietary pattern through dietary supplements as vitamins, with or without pharmaceutical antioxidants, which may provide a potential therapeutics approach in obesity comorbidities

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Effects of a Leucine and Pyridoxine-Containing Nutraceutical on Fat Oxidation, and Oxidative and Inflammatory Stress in Overweight and Obese Subjects

Cited by 59 publications

References 37 publications

Fat utilization and arterial hypertension in overweight/obese subjects

Fat utilization and arterial hypertension in overweight/obese subjects

Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects

Role of Oxidative Stress and Associated Alteration in Enzyme Activities in Obesity Comorbidities

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