Effects of a Lactobacillus reuteri BR11 Mutant Deficient in the Cystine-Transport System in a Rat Model of Inflammatory Bowel Disease

Atkins, H.; Geier, Mark S.; Prisciandaro, Luca D.; Pattanaik, A.K.; Forder, R. E. A.; Turner, Mark S.; Howarth, Gordon S.

doi:10.1007/s10620-011-1943-0

Cited by 15 publications

(12 citation statements)

References 37 publications

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“…Lactobacillus reuteri BR11 reduces the severity of experimental IBD, principally via a mechanism of thiol production [43]. Male Sprague–Dawley rats were administered 2% DSS to induce colitis.…”

Section: Resultsmentioning

confidence: 99%

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Evidence of the Anti-Inflammatory Effects of Probiotics and Synbiotics in Intestinal Chronic Diseases

et al. 2017

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Probiotics and synbiotics are used to treat chronic diseases, principally due to their role in immune system modulation and the anti-inflammatory response. The present study reviewed the effects of probiotics and synbiotics on intestinal chronic diseases in in vitro, animal, and human studies, particularly in randomized clinical trials. The selected probiotics exhibit in vitro anti-inflammatory properties. Probiotic strains and cell-free supernatants reduced the expression of pro-inflammatory cytokines via action that is principally mediated by toll-like receptors. Probiotic administration improved the clinical symptoms, histological alterations, and mucus production in most of the evaluated animal studies, but some results suggest that caution should be taken when administering these agents in the relapse stages of IBD. In addition, no effects on chronic enteropathies were reported. Probiotic supplementation appears to be potentially well tolerated, effective, and safe in patients with IBD, in both CD and UC. Indeed, probiotics such as Bifidobacterium longum 536 improved the clinical symptoms in patients with mild to moderate active UC. Although it has been proposed that probiotics can provide benefits in certain conditions, the risks and benefits should be carefully assessed before initiating any therapy in patients with IBD. For this reason, further studies are required to understand the precise mechanism by which probiotics and synbiotics affect these diseases.

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Section: Resultsmentioning

confidence: 99%

“…Probiotic administration partially alleviated the DSS effects, with a minor improvement in the crypt area. The administration of the mutant strain to colitic animals failed to produce significant differences when compared with the DSS control [43]. …”

Section: Resultsmentioning

confidence: 99%

Evidence of the Anti-Inflammatory Effects of Probiotics and Synbiotics in Intestinal Chronic Diseases

et al. 2017

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“…Studies have highlighted the profound effect of diet on gut microbiota composition and the connection to immune pathways [55,56,57]. Inadequate colonization of infant gut or alteration in the microbiota profile (dysbiosis) is now considered a strong risk factor for chronic disorders, such as allergic and autoimmune diseases [58,59,60]. A recent study found a significant relationship between gut microbiota constituents at one month of age and the later development of specific serum IgE against food proteins.…”

Section: Gut Microbiota As a Nutriepigenomic Playermentioning

confidence: 99%

The Influence of Early Life Nutrition on Epigenetic Regulatory Mechanisms of the Immune System

et al. 2014

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The immune system is exquisitely sensitive to environmental changes. Diet constitutes one of the major environmental factors that exerts a profound effect on immune system development and function. Epigenetics is the study of mitotically heritable, yet potentially reversible, molecular modifications to DNA and chromatin without alteration to the underlying DNA sequence. Nutriepigenomics is an emerging discipline examining the role of dietary influences on gene expression. There is increasing evidence that the epigenetic mechanisms that regulate gene expression during immune differentiation are directly affected by dietary factors or indirectly through modifications in gut microbiota induced by different dietary habits. Short-chain fatty acids, in particular butyrate, produced by selected bacteria stains within gut microbiota, are crucial players in this network.

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“…Lactobacillus has been reported to be beneficial to the host and its increase may be related to the relief of colitis . However, different strains of Lactobacillus may have different effects . Many uncultured Lactobacillus were detected in 5‐ASA‐treated colitis group in the current study.…”

Section: Discussionmentioning

confidence: 48%

Bacterial immune interaction in experimental colitis

Xue

Ouyang

Zhou

et al. 2013

J of Digest Diseases

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Effects of a Lactobacillus reuteri BR11 Mutant Deficient in the Cystine-Transport System in a Rat Model of Inflammatory Bowel Disease

Abstract: Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the

Cited by 15 publications

References 37 publications

Evidence of the Anti-Inflammatory Effects of Probiotics and Synbiotics in Intestinal Chronic Diseases

Evidence of the Anti-Inflammatory Effects of Probiotics and Synbiotics in Intestinal Chronic Diseases

The Influence of Early Life Nutrition on Epigenetic Regulatory Mechanisms of the Immune System

Bacterial immune interaction in experimental colitis

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