Effects of a human milk oligosaccharide, 2′-fucosyllactose, on hippocampal long-term potentiation and learning capabilities in rodents

Vázquez, Enrique; Barranco, A.; Ramírez, Miguel Àngel Acedo; Gruart, Agnès; Delgado‐García, José M.; Martı́nez-Lara, Esther; Blanco, Santos; Martín, María Jesús Sánchez; Castanys, Esther; Buck, Rachael H.; Prieto, P.; Rueda, Ricardo

doi:10.1016/j.jnutbio.2014.11.016

Cited by 135 publications

(118 citation statements)

References 57 publications

(51 reference statements)

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“…The more widespread B-GOS effect, relative to FOS, may reflect the former's greater Bifidogenic capacity. There is also evidence of substantial benefits conferred by the human milk oligosaccharide 2′-fucosyllactose [29]. Relative to vehicle, male rodents (both Sprague–Dawley rats and C57BL/6 mice) showed enhanced associative learning and working memory, as well as higher expression of hippocampal and striatal BDNF and increased hippocampal long-term potentiation.…”

Section: Rodent Modelsmentioning

confidence: 99%

Psychobiotics and the Manipulation of Bacteria–Gut–Brain Signals

Sarkar

Lehto

Harty

et al. 2016

Trends in Neurosciences

777

565

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Psychobiotics were previously defined as live bacteria (probiotics) which, when ingested, confer mental health benefits through interactions with commensal gut bacteria. We expand this definition to encompass prebiotics, which enhance the growth of beneficial gut bacteria. We review probiotic and prebiotic effects on emotional, cognitive, systemic, and neural variables relevant to health and disease. We discuss gut–brain signalling mechanisms enabling psychobiotic effects, such as metabolite production. Overall, knowledge of how the microbiome responds to exogenous influence remains limited. We tabulate several important research questions and issues, exploration of which will generate both mechanistic insights and facilitate future psychobiotic development. We suggest the definition of psychobiotics be expanded beyond probiotics and prebiotics to include other means of influencing the microbiome.

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Section: Rodent Modelsmentioning

confidence: 99%

Psychobiotics and the Manipulation of Bacteria–Gut–Brain Signals

Sarkar

Lehto

Harty

et al. 2016

Trends in Neurosciences

777

565

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“…Specific HMO structures, including lacto- N -fucopentaose (LNFP) III and LNnT, have been reported for their relationship to immune modulation (Atochina et al 2001, Terrazas et al 2001). HMOs are also associated with improved learning and memory (Vazquez et al 2015). …”

Section: Structure-function Associations Of Milk Glycansmentioning

confidence: 99%

Milk Glycans and Their Interaction with the Infant-Gut Microbiota

Kirmiz

Robinson

Shah

et al. 2018

Annu. Rev. Food Sci. Technol.

105

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Human milk is a unique and complex fluid that provides infant nutrition and delivers an array of bioactive molecules that serve various functions. Glycans, abundant in milk, can be found as free oligosaccharides or as glycoconjugates. Milk glycans are increasingly linked to beneficial outcomes in neonates through protection from pathogens and modulation of the immune system. Indeed, these glycans influence the development of the infant and the infant-gut microbiota. Bifidobacterium species commonly are enriched in breastfed infants and are among a limited group of bacteria that readily consume human milk oligosaccharides (HMOs) and milk glycoconjugates. Given the importance of bifidobacteria in infant health, numerous studies have examined the molecular mechanisms they employ to consume HMOs and milk glycans, thus providing insight into this unique enrichment and shedding light on a range of translational opportunities to benefit at-risk infants.

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“…However, HMGs may have functions beyond interactions with microbes, as more recent studies suggest that HMGs may regulate multiple physiological functions in infants, including gene expression and immune and allergic responses [6, 7]. HMGs also regulate gut motility [8] and enhance learning and memory [9], suggesting their role in neuronal responses and cognition. However, the mechanisms underlying these physiological functions of HMGs are still unclear.…”

Section: Introductionmentioning

confidence: 99%

Human DC-SIGN binds specific human milk glycans

Noll

Lasanajak

et al. 2016

Biochemical Journal

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Human milk glycans (HMGs) are prebiotics, pathogen receptor decoys, and regulators of host physiology and immune responses. Mechanistically, human lectins (glycan-binding proteins, hGBPs) expressed by dendritic cells (DC) are of major interest, as these cells directly contact HMGs. To explore such interactions, we screened many C-type lectins and Siglecs expressed by DC for glycan binding on microarrays presenting over 200 HMGs. Unexpectedly, DC-SIGN showed robust binding to many HMGs, whereas other C-type lectins failed to bind, and Siglecs-5 and -9 showed weak binding to a few glycans. By contrast, most hGBPs bound to multiple glycans on other microarrays lacking HMGs. An α-linked fucose residue was characteristic of HMGs bound by DC-SIGN. Binding of DC-SIGN to the simple HMGs 2′-fucosyllactose (2′-FL) and 3-fucosyllactose (3-FL) was confirmed by flow cytometry to beads conjugated with 2′-FL or 3-FL, as well as the ability of the free glycans to inhibit DC-SIGN binding. 2′-FL had an IC50 of ~1 mM for DC-SIGN, which is within the physiological concentration of 2′-FL in human milk. These results demonstrate that DC-SIGN among the many hGBPs expressed by DC binds to α-fucosylated HMGs, and suggest that such interactions may be important in influencing immune responses in the developing infant.

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Effects of a human milk oligosaccharide, 2′-fucosyllactose, on hippocampal long-term potentiation and learning capabilities in rodents

Cited by 135 publications

References 57 publications

Psychobiotics and the Manipulation of Bacteria–Gut–Brain Signals

Psychobiotics and the Manipulation of Bacteria–Gut–Brain Signals

Milk Glycans and Their Interaction with the Infant-Gut Microbiota

Human DC-SIGN binds specific human milk glycans

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