Effects of a home-exercise programme in childhood survivors of acute lymphoblastic leukaemia on physical fitness and physical functioning: results of a randomised clinical trial

Manchola-González, Jahn Dubery; Bagur-Calafat, Caritat; Girabent-Farrés, Montserrat; Serra-Grima, Josep Ricard; Pérez, Roser Álvarez; Garnacho-Castaño, Manuel Vicente; Badell, Isabel; Ramírez‐Vélez, Robinson

doi:10.1007/s00520-019-05131-2

Cited by 34 publications

(31 citation statements)

References 24 publications

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“…A one-sample Wilcoxon signed-rank test was performed on the adherence rate of patients with a set threshold of 80%, based on the hypothesis. The threshold was based on a study involving home-based distance-delivery exercise interventions administered to patients with acute lymphoblastic leukemia in remission, which showed an 80% adherence rate for a 75% completion rate [ 15 ].…”

Section: Methodsmentioning

confidence: 99%

“…Physical activity and exercise provide physiological and mechanical stimulation that are beneficial for muscle and bone health [ 14 ] and the cardiovascular system [ 15 ]. Specific types of exercises, such as plyometric (defined as high impact, eg, jumping) and resistance exercises, have been shown to decrease bone impairments in other cancer populations with bone-specific deficits (breast cancer and prostate cancer) [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…The feasibility of the pilot intervention was evaluated by assessing the completion and adherence rate of patients, in addition to the occurrence of training adaptation because of participants’ pain and adverse events. It is hypothesized that direct supervision, possible through telehealth technologies, will lead to an adherence rate of 80% and a completion rate of 75% [ 15 ]. The secondary aim of this study is to explore the effects of the intervention on functional performance, muscle function, and bone health.…”

Section: Introductionmentioning

confidence: 99%

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Home-Based Telehealth Exercise Intervention in Early-On Survivors of Childhood Acute Lymphoblastic Leukemia: Feasibility Study

Lambert¹,

Alos²,

Bernier³

et al. 2021

JMIR Cancer

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Background Acute lymphoblastic leukemia is the most common type of pediatric cancer. Acute lymphoblastic leukemia causes an altered bone mineral homeostasis state, which can contribute to osteopenia, and bone fractures, most commonly vertebral fractures. With the increasing number of childhood cancer survivors, late adverse effects such as musculoskeletal comorbidities are often reported and are further influenced by inactive lifestyle habits. Physical activity has been shown to increase the mechanical workload of the bone, mitigating bone impairment in other cancer-specific populations. Objective This interventional pilot study aims to investigate the use of telehealth to deliver a home-based exercise intervention for early-on survivors of bone marrow–related hematological malignancies and to assess its impact on survivors’ musculoskeletal and functional health. Methods We aimed to recruit a group of 12 early-on survivors of acute lymphoblastic leukemia, within 6 months to 5 years of treatment, to participate in and complete the proposed telehealth intervention with a parent. The 16-week intervention included 40 potential home-based physical activity interventions supervised by a kinesiologist through a telehealth internet platform, with monthly progression. Patients were recruited to the cohort if they were able to participate in the intervention during the first month (minimum 12 weeks of intervention). Evaluation before and after the intervention protocol highlighted differences in functional capacities and musculoskeletal health of patients using mechanography, peripheral quantitative computed tomography, 6-minute walk test, and grip force test. Results The recruitment rate for the intervention was low (12/57, 21% of contacted patients). Of 12 patients, 3 were excluded (1=relapse, 1=failure to meet technical requirements, and 1=abandoned). The 9 patients who completed the intervention (6 girls; mean age 10.93, SD 2.83 years; mean BMI 21.58, SD 6.55 kg/m2; mean time since treatment completion 36.67, SD 16.37 months) had a mean adherence of 89% and a completion rate of 75%. In addition, these patients showed functional improvements in lower limb muscle force and power as well as in the 6-minute walk test distance. Participants also showed improved bone health after the intervention on the following parameters: bone mineral content, stress-strain index, total and cortical cross-sectional area at the 14% site (P=.03, P=.01, P=.01, and P=.001, respectively) and 38% site of the tibia (P=.003, P=.04, P=.001, and P=.003, respectively). Conclusions High adherence and participation rates suggest that telehealth is a feasible method to deliver exercise interventions to young early-on survivors of acute lymphoblastic leukemia. The proposed intervention seems promising in providing benefits to patients’ functional performance and bone health, but a large-scale study is needed to confirm this assumption.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Home-Based Telehealth Exercise Intervention in Early-On Survivors of Childhood Acute Lymphoblastic Leukemia: Feasibility Study

Lambert¹,

Alos²,

Bernier³

et al. 2021

JMIR Cancer

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“…After determining the classification of grades, the five grades are assigned with 5-point assignment method, with significant impact rating interval [4. 5,5], general impact rating interval [3.5, 4.4], basic impact rating interval [3, 3.4], not much impact rating interval [2.5, 2.9], and no impact on rating interval [0, 2.4]. The evaluation system of each column is shown in Table 1.…”

Section: The Process Of Determining the Evaluation Index Of The Influmentioning

confidence: 99%

“…4 Based on the improvement of the information input mode of football consumption model, scholars from National University of Singapore proposed a human health impact assessment model based on neural network algorithm. 5 The data signals input to the model were collected by nodes in a normalized way, and the information simulation processing of data signals was realized by neural network algorithm. Scholars from Macao University of science and technology of China found that most colleges and universities still follow the traditional thinking of human body physique research simulation, ignoring the use of intelligent information technology.…”

Section: Introductionmentioning

confidence: 99%

Influencing Factors of College Students’ Physical Health Under the Intervention of Football

Gang

2021

Rev Bras Med Esporte

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The current football can effectively exercise the body of college students and improve their physical health. How to use modern intelligent technology to perform quantitative research on the influencing factors of football on college students’ physical health is the current development trend. Based on this, this paper studies the influencing factors of college students’ physical health under the intervention of football. First of all, this paper puts forward an analysis model of college students’ physical health based on the sarsa algorithm. The autocorrelation function is used to simulate and process the students’ physical information. Through the maximum value of the autocorrelation function curve in the detection process, the detection signal is restored, then the error of the sarsa algorithm is analyzed. Secondly, this paper expounds the influence factors of sarsa algorithm on students’ physical health in football. Fuzzy evaluation method and analytic hierarchy process are used in the evaluation. Aiming at the shortcomings of AHP, the improved sarsa algorithm is used for comprehensive analysis, and an adaptive simulation evaluation system is established. Finally, the effectiveness of the sarsa algorithm in this system is verified by many football experiments.

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Physical therapy interventions, other than general physical exercise interventions, in children and adolescents before, during and following treatment for cancer

Ospina

McComb

Pritchard

et al. 2021

Cochrane Database of Systematic Reviews

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Effects of a home-exercise programme in childhood survivors of acute lymphoblastic leukaemia on physical fitness and physical functioning: results of a randomised clinical trial

Cited by 34 publications

References 24 publications

Home-Based Telehealth Exercise Intervention in Early-On Survivors of Childhood Acute Lymphoblastic Leukemia: Feasibility Study

Home-Based Telehealth Exercise Intervention in Early-On Survivors of Childhood Acute Lymphoblastic Leukemia: Feasibility Study

Influencing Factors of College Students’ Physical Health Under the Intervention of Football

Physical therapy interventions, other than general physical exercise interventions, in children and adolescents before, during and following treatment for cancer

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