Effects of a home based exercise intervention on cardiac biomarkers, liver enzymes, and cardiometabolic outcomes in CABG and PCI patients

Abstract

Background: We investigated the impact of a home-based exercise intervention (HBEI) on cardiac biomarkers, liver enzymes, cardiometabolic outcomes, and health-related quality of life (HRQL) in clinically stable patients after coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI). Materials and Methods: The study was a nonrandomized clinical trial conducted in Tehran, Iran, from July 2019 to January 2020. Forty cardiac patients (after the cardiac intervention, CABG, n = 32; PCI, n = 8) were recruited based on the study inclusion criteria and were allocated consecutively to one of two groups: (1) HBEI ( n = 18) and (2) conventional center-based exercise program (CBEP, n = 22). The CBEP group performed the routine exercise program of Sadr Heart Clinic, and the HBEI group performed a home-based remotely monitored exercise protocol, both three times per week, for 8 weeks. The following variables were assessed before and after the intervention: anthropometric measures; blood pressure; lipid profile; cardiac biomarkers including cardiac troponin I, creatine kinase, and total and Mb isozyme; liver enzymes including aspartate aminotransferase and alanine aminotransferase; creatinine; urea; exercise capacity; and HRQL. Results: In comparison with pretest in both CBEP and HBEI groups, a significant improvement in all of the measured variables ( P < 0.05), but not in ejection fraction was observed ( P > 0.05). Moreover, in the CBEP group, a more significant decline in troponin I levels ( P = 0.03), and in the HBEI group, a greater reduction in weight ( P = 0.01) and body mass index ( P = 0.04) occurred. Conclusion: The findings suggest that a properly designed and monitored HBEI may be as effective as conventional center-based cardiac rehabilitation (CR) exercise programs and should be encouraged in those cardiac patients who are unable or uninterested in conventional center-based CR exercise programs.

Exploring the Rehabilitation Needs of Patients with Coronary Artery Diseases: An Effort to Design A Contextual Home-based Cardiac Rehabilitation through A Qualitative Enquiry

“…This nding aligns with existing literature emphasizing the signi cance of supervised exercise programs for cardiac rehabilitation [32]. Research suggests that supervised exercise interventions lead to better adherence and outcomes than unsupervised programs [33].…”

Home-based power training improves functional parameters and blood pressure after coronary artery bypass graft surgery: preliminary study

“…Despite such benefits, evidence indicates that treatment center rehabilitation adherence is still rather low (ARENA et al, 2012;THOMAS et al, 2019). Thus, homebased rehabilitation is an alternative for these patients (SMITH et al, 2011;OLGOYE;SAMADI;JAMALIAN, 2021).…”