Effects of a high dose of diethylstilbestrol on the delivery of the placenta after corticoid-induced parturition in cattle

Grünert, E; Ahlers, D; Jöchle, W.

doi:10.1016/0093-691x(75)90142-9

Cited by 24 publications

(3 citation statements)

References 19 publications

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“…dexamethasone and flumethasone) has induced births in cattle has been the high been used successfully to terminate rates of retained placentae in the latter, pregnancies prematurely in exotic and tropical Retained foetal membranes in cows may be beef and dairy cows (Jochle, 1971 and1973; caused by a number of factors, such as Wagner, Willham and Evans, 1974;Davis, pathogens (Roberts, 1971), nutrition (Julien, Kesler, Jenkins, Garverick, Massey, Conrad, Jones and Moxon, 1976;Zamet, Bierschwal and Day, 1979;Prakash and Colenbrander, Erb, Callahan, Chew and Madan, 1984). A few reports have been published where injection of oestradiol benzoate along with dexamethasone reduced the incidence of retained placentae (Garverick, Day, Mather, Gomez, and Thompson, 1974;Grunert, Ahlers and Jochle, 1975), while others have not reported any beneficial effects (LaVoie and Moody, 1973;Schmitt, Garverick, Mather, Sikes, Day and Erb, 1975;Kesler, Peterson, Erb and Callahan, 1976;Bolte, Garverick, Kesler, Day and Mather, 1977;Prakash and Madan, 1984). It is now well established that all of been fully exploited in some countries like these factors eventually lead to an alteration of the endocrine profile of the animal around the time of parturition.…”

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Concentrations of plasma hormones in relation to placental retention in Karan Swiss cows during and after induction of parturition with dexamethasone and stilboestrol dipropionate

Prakash

Madan

1985

Anim. Sci.

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Five Karan Swiss cows were allowed to calve spontaneously and served as controls (Group A), while another 10 were induced to calve about 1 month prior to expected term using either 25 mg dexamethasone alone (Group B) or 25 mg dexamethasone in combination with 25 mg stilboestrol dipropionate (Group C). Blood samples were collected prior to, and for 50 days following, parturition for subsequent hormone analysis, and observations were made on the occurrence of retained placentae.Parturition was successfully induced in all treated cows within 72 h of drug administration. Placental membranes were retained for 24 h in all treated animals and were manually removed in the farm veterinary clinic. No incidence of placental retention occurred in control cows.Mean plasma oestradiol-17β in control cows showed a gradual rise from days 30 to 5 pre partum, followed by a sharp increase to peak value 1 day before calving. The rise in mean oestradiol-17β levels in the 2 days before parturition in controls was significantly greater than that recorded for the treated animals. A precipitous drop in plasma oestradiol-17β level occurred following parturition in all groups, with the levels staying low for the rest of the sampling period. Drug administration to animals in groups B and C resulted in a rapid and significant drop in plasma progesterone concentrations to a level similar to that for control animals at parturition. Subsequently, the plasma progesterone remained low in all treatment groups. Mean plasma cortisol levels showed a significant but transient increase at calving in control cows, but were suppressed for at least 48 h following drug administration in treated cows before exhibiting a rebound phenomenon to reach high values after calving.It is concluded that for normal placental expulsion, oestradiol-17β levels are more critical than progesterone, and that the rise in oestradiol-17β and fall in progesterone levels pre partum must be gradual.

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Concentrations of plasma hormones in relation to placental retention in Karan Swiss cows during and after induction of parturition with dexamethasone and stilboestrol dipropionate

Prakash

Madan

1985

Anim. Sci.

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“…However, the use of estrogens in various induction regimes to mimic normal hormonal events at parturition has yielded conflicting results [13][14][15][16]. The effect of corticoids and cloprostenol to induction of parturition is reported in cows [17][18][19].…”

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Comparison of Two Different Protocols for Induction of Parturition in Heifers with or without Estradiol Benzoate

Mehrvar¹,

Hamali²,

Adel³

2017

JLS

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Objectives of this study were to investigate the efficacy of dexamethasone in combination with estradiol benzoate in controlled induction of parturition in heifers, especially in the subjects of retained fetal membranes and dystocia caused by fetal oversize. A total number of 100 Holstein-Friesian heifers aged 24-25 months, mean weight 450 kg and body condition score of 3-4 from a dairy herd located in the suburb of Tabriz with similar nutrition and management systems were allocated at random into two groups. Group A (Control, n = 50) heifers, after passing the minimum 270 d of pregnancy were injected with 30 mg dexamethasone IM. Group B (Treatment, n = 50) heifers with the same period of pregnancy received 30 mg dexamethasone plus 20 mg estradiol benzoate IM on the same days of pregnancy. The overall durations of initial treatments to induction of parturition were (41.50 ± 2.65) h in group A and (37.50 ± 1.27) h in group B. In group A, more dystocia cases were observed than in group B. After parturition, group A showed a higher percentage of retention of fetal membranes as well as the calf mortality and dystocia compared to group B. The differences between two groups were statistically significant (P < 0.05). In conclusion, our results indicate that induction of parturition by estradiol benzoate and dexamethasone together will be more effective than dexamethasone alone because of the less retention of fetal membranes, easy calving and shorter time from induction to parturition.

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“…Therefore, one would expect to be able to show this effect of foetal sire on the placental ability to synthesize oestrogens. The relationships between maternal plasma ster¬ oids and retained placenta have been discussed in several studies (Jochle 1971;Garverick et al 1974;Agthe & Kolm 1975;Grunert et al 1975). Hoff¬ mann et al (1973) suggested the major decline in plasma oestrogens was related to decreased syn¬ thesis in the placenta.…”

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Oestrogen synthesis by bovine foetal placenta at normal parturition

Larsson

Wagner

Sachs

1981

Acta Endocrinologica

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In vitro conversion of C19-[3H]androstenedione and C21-[3H]pregnenolone steroids to oestrogens was studied in tissue cultures prepared from bovine cotyledons collected 10\p=n-\240min after natural parturition. A total of 17 cows was used, 15 had normal parturitions and 2 cows required assistance due to weak and prolonged labour. At collection of tissues, blood samples were drawn from the cows and peripheral plasma oestrogen levels were determined by radioimmunoassay. Percentage conversion to unconjugated and conjugated oestrogens was estimated for each cow from 6 tissue culture replicates for each precursor. The steroids were extracted with toluene and separated by phenolic extraction and column chromatography. The repeatability of conversion rate was very high. Incubation with androstenedione yielded consistently higher conversion rates than incubation with pregnenolone. Independent of precursor the conversion rates, within cows, ranked unconjugated Oe1 > conjugated Oe1 > unconjugated Oe2 > conjugated Oe2. The conversion rates decreased significantly with increasing intervals from parturition to collection of material. Lower conversion rates were found for cultures of tissues from the 2 cows with weak labour when compared to cultures from normally calving cows. The sire of the foetus had an influence on conversion rate in the tissue cultures. The plasma oestrogen concentrations of the cows decreased significantly with an increased interval from parturition to blood-sampling. With the exception of one cow, the tissue culture conversion rates and the plasma oestrogen levels of the cows were significantly correlated.

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Effects of a high dose of diethylstilbestrol on the delivery of the placenta after corticoid-induced parturition in cattle

Cited by 24 publications

References 19 publications

Concentrations of plasma hormones in relation to placental retention in Karan Swiss cows during and after induction of parturition with dexamethasone and stilboestrol dipropionate

Concentrations of plasma hormones in relation to placental retention in Karan Swiss cows during and after induction of parturition with dexamethasone and stilboestrol dipropionate

Comparison of Two Different Protocols for Induction of Parturition in Heifers with or without Estradiol Benzoate

Oestrogen synthesis by bovine foetal placenta at normal parturition

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