Effects of a heat and moisture exchanger and a heated humidifier on respiratory mucus in patients undergoing mechanical ventilation

Nakagawa, Naomi Kondo; Macchione, Mariângela; Petrolino, Helen Maria Scapolan; Guimarães, Eliane Tigre; King, Malcolm; Saldiva, Paulo Hilário Nascimento; Lorenzi-Filho, Geraldo

doi:10.1097/00003246-200002000-00004

Cited by 58 publications

(48 citation statements)

References 27 publications

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“…It is possible that effects on respiratory mucus could have been present if a longer period had been examined. Anaesthesia, tracheostomy, MV and the use of a heat and moisture exchanger have all been related to reductions in MCT [18,[26][27][28]. However, in the current study, these factors were equally applied to all groups.…”

Section: Discussionmentioning

confidence: 71%

“…Respiratory mucus samples were gently collected using a sterile suction technique [14] at times 0, 1 and 2 h and the samples stored at -70uC for further analysis, as previously described [18].…”

Section: Mucus Collectionmentioning

confidence: 99%

“…The clearance experiments were performed at an ambient temperature, which was kept at 20uC (68uF). During the measurements, the frog palate was maintained inside an acrylic chamber, 100% relative humidity was provided by an ultrasonic nebuliser system using a 1:1 solution of 0.9% NaCl:Ringer9s solution [16,18].…”

Section: Mucus Analysismentioning

confidence: 99%

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Effects of acute hypovolaemia by furosemide on tracheal transepithelial potential difference and mucus in dogs

Nakagawa¹

2004

European Respiratory Journal

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Furosemide is a potent diuretic that affects water transfer across the respiratory epithelium, which is closely related to the transepithelial potential difference (PD). Water is a critical factor that determines mucus transport; an important lung defence mechanism that removes particles and microorganisms from the respiratory system.The aim of the present study was to investigate the acute effects of furosemide and hypovolaemia on tracheal PD and mucus properties. A total of 36 male mixed-breed dogs were submitted to anaesthesia, mechanical ventilation and haemodynamic monitoring. They were randomly assigned to three groups consisting of: a control group, a furosemide (40 mg i.v.)zhypovolaemia group, and a furosemide (40 mg i.v.)z volume replacement group. Tracheal PD and mucus samples were collected at time 0, 1 and 2 h after intervention. Mucus properties were analysed by means of a magnetic microrheometer and in vitro mucociliary transportability on the frog palate.Compared to controls, furosemide decreased PD to intermediate values, and only significantly when associated with hypovolaemia (-13¡5 and -8¡2 mV, time 0 and 2 h, respectively).In addition to the direct effect of furosemide, these results indicate that hypovolaemia also affects ion transport in the tracheal membrane. Furosemide and hypovolemia have no acute effects on respiratory mucus properties. Eur Respir J 2004; 24: 805-810.

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Section: Discussionmentioning

confidence: 71%

Section: Mucus Collectionmentioning

confidence: 99%

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Effects of acute hypovolaemia by furosemide on tracheal transepithelial potential difference and mucus in dogs

Nakagawa¹

2004

European Respiratory Journal

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“…Invasive ventilation always requires a humidifying system [20], in non-invasive ventilated patients a humidifier should be prescribed according to the patient's symptoms [16].…”

Section: Humidifiersmentioning

confidence: 99%

Guidelines for Non-Invasive and Invasive Mechanical Ventilation for Treatment of Chronic Respiratory Failure

Windisch¹,

Walterspacher²,

Siemon³

et al. 2010

Pneumologie

139

108

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“…We may obtain mucus samples from the nasal cavity by using tracheal aspiration tubes, carefully positioned on the floor or near the lateral wall. We must use the minimum vacuum possible, which helps in collecting the samples with little mucus stirring, in an attempt to avoid protein denaturation and the incorporation of air bubbles 7 . We may also use cytology brushes, which have the disadvantage of collecting little amounts of mucus 8 .…”

Section: Mucus Study -Nasal Mucus Collectionmentioning

confidence: 99%

Métodos de estudo do transporte mucociliar

Trindade

Júnior

Mion

et al. 2007

Rev. Bras. Otorrinolaringol.

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Mucoci liary transport dysfunctions can impair the quality of life of patients suffering from chronic rhinossinusitis and lead to severe consequences such as alterations in respiratory physiology or even death as in cases of cystic fibrosis and primary ciliary dyskinesia. Therefore, it is crucial to understand the physiology of the mucociliary apparatus and how its components (cilia, mucus-periciliary layer and its interaction) affect the clearance of respiratory secretions. Aims: This paper aims to review and to discuss different techniques for studying mucociliary transport and their clinical and experimental applicability. Conclusions: The methods listed in this revision provide us with valuable information about different aspects of the mucociliary transport. Some of the methods listed are more suitable for clinical practice and present reproducible results. Others, show only applicability in experimental settings due to technical difficulties or financial limitations. However, it is important to emphasize that up to now there is no method that can evaluate ciliary beating frequency (CBF) in vivo and in situ. Such a method would become a valuable tool in the scientific scenario and in the clinical practice, supporting the diagnosis of ciliary dyskinesias and avoiding the use of invasive procedures to corroborate the clinical suspicion

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Effects of a heat and moisture exchanger and a heated humidifier on respiratory mucus in patients undergoing mechanical ventilation

Cited by 58 publications

References 27 publications

Effects of acute hypovolaemia by furosemide on tracheal transepithelial potential difference and mucus in dogs

Effects of acute hypovolaemia by furosemide on tracheal transepithelial potential difference and mucus in dogs

Guidelines for Non-Invasive and Invasive Mechanical Ventilation for Treatment of Chronic Respiratory Failure

Métodos de estudo do transporte mucociliar

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