Effects of a Healthy Lifestyle Education on the Incidence of Metabolic Syndrome in Children during a 13-Year Follow-up

Jalali-Farahani, Sara; Amiri, Parisa; Masihay-Akbar, Hasti; Cheraghi, Leila; Karimi, Mehrdad; Azizi, Fereidoun

doi:10.1007/s12529-017-9680-1

Cited by 3 publications

(3 citation statements)

References 31 publications

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“…The details of more relevant studies that were excluded are demonstrated in supporting information Table S1. Studies were excluded if they: (1) reported correlation coefficient, standard, or unstandard coefficient ( β or B) for MetS prevalence; or reported mean ± SD or mean ± SE or median (interquartile range) of circulating vitamin D levels in those with and without MetS 15,39–41 ; (2) considered MetS as the exposure and serum vitamin D level as the outcome 42,43 ; (3) reported only serum 1,25 (OH)2 D3 levels in both healthy and MetS groups; or assessed the relation of circulating 1,25 (OH)2 D3 and components of MetS 29,44 45 .…”

Section: Methodsmentioning

confidence: 99%

Circulating serum vitamin D levels in relation to metabolic syndrome in children: A systematic review and dose–response meta‐analysis of epidemiologic studies

2021

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Findings from epidemiologic studies that evaluated the relationship between serum vitamin D levels and metabolic syndrome (MetS) in children were contradictory. We conducted a systematic review and meta-analysis on the relation of serum 25(OH)D levels and MetS in children. A comprehensive search was conducted in electronic databases, up to November 2020. Eleven cross-sectional studies that reported the link between circulating vitamin D levels and MetS in children were included in the analysis. Combining 11 effect sizes from 11 cross-sectional studies with 22,196 participants revealed that highest versus lowest serum vitamin D concentration was significantly associated with a 50% reduced odds of MetS in children (OR: 0.50; 95% CI: 0.39, 0.64). Subgroup analysis by study location revealed decreased odds of MetS in both non-Asian (OR: 0.45; 95%CI: 0.33, 0.63) and Asian countries (OR: 0.54; 95% CI: 0.39, 0.76) with no heterogeneity in these subgroups. When we confined the studies to those with representative populations (n = 21,611), a significant inverse association was found between highest versus lowest circulating vitamin D level and MetS (OR: 0.55; 95%CI: 0.42, 0.71). Dose-response analysis showed that each 10 ng/ml (or 25 nmol/L) in serum vitamin D was linearly related to a 12% reduced odds of MetS (OR: 0.88; 95%CI: 0.78, 0.99) in children. A nonlinear association was also detected between serum 25(OH)D and MetS. This meta-analysis revealed that circulating vitamin D concentration was inversely associated with odds of MetS in children, in a dose-response fashion. The same finding was found in the studies with representative populations.

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Section: Methodsmentioning

confidence: 99%

Circulating serum vitamin D levels in relation to metabolic syndrome in children: A systematic review and dose–response meta‐analysis of epidemiologic studies

2021

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“…The second phase of this study has tested a number of interventions on targeted sub-groups of the population including schoolchildren (97). A recent publication has shown that a healthy lifestyle education can reduce the short term (6 year) risk of the metabolic syndrome in children (98) with similar looking but potentially longer lasting benefits in adolescents (99).…”

Section: Preventing the Metabolic Syndromementioning

confidence: 99%

Prevention of Obesity and Metabolic Syndrome in Children

Gregory

2019

Front. Endocrinol.

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In recent decades, the prevalence of overweight and obesity has become increasingly common such that it is now the major nutritional problem worldwide. Obesity occurs when dietary energy intake exceeds energy expenditure and has arisen in many societies due to an increasingly “obesogenic” environment in which physical activity has declined and yet children continue to be exposed to unhealthy, energy-dense diets. Additional risks for the development of obesity also include psychological issues and genetic factors. Obesity has many adverse health consequences including development of insulin resistance, Type 2 diabetes, and the metabolic syndrome. There are also important genetic influences on the likelihood of developing insulin resistance. Given the limited success of therapeutic interventions to treat obesity and the metabolic syndrome, there has been an increased interest in preventative strategies. These are likely to be most successful when targeting the young and will require a combination of approaches which will need inter-disciplinary collaborations across health and local government to target families, schools, and local environments to facilitate behavior changes which influence young people's eating behaviors and habitual levels of physical activity.

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“…It could be that these are safe in normal-weight individuals without any heredity for MS but possibly not in women with an increased metabolic risk, in whom insulin sensitivity may already be disturbed [47]. The role of healthy diet, physical activity, and sleep are already well-known health promoting factors [48]; however, these factors in the present study displayed only a marginal impact, possibly due to the subjective nature of the data.…”

Section: Discussionmentioning

confidence: 72%

Features of Childhood Growth, Lifestyle, and Environment Associated with a Cardiometabolic Risk Score in Young Adults

et al. 2021

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Introduction: In young adults, the metabolic syndrome is rare. To better assess the risks for future cardiovascular disease, a cardiometabolic score can be used, ranking the disease risk in each subject. The score is a continuous variable summarising the individual z-scores for waist circumference, blood pressure, blood levels of glucose, triglycerides and HDL-cholesterol. Our main aim was to assess the association between early childhood growth and the cardiometabolic score in young adults. Methods: Study participants were recruited among subjects in the longitudinal population-based GrowUp 1990 Gothenburg study. Those with information on weight and length at birth, as well as weight, height, waist circumference, and parental BMI at ten years of age were invited to participate in a health survey at 18-20 years of age. 513 young adults (female 51%) were included. Multivariable linear stepwise regression analysis was applied. Results: The mean (SD) BMI was 22.2 (3.26) in males and 21.3 (2.69) kg/m² in females; the cardiometabolic score was 0.24 (3.12) and -0.22 (3.18), respectively. A statistically significantly higher score (p<0.001) was seen in individuals with metabolic syndrome, as defined by IDF. After controlling for adult lifestyle features, BMI z-score at ten years of age was significant risk factor in both sexes for an elevated cardiometabolic score in early adulthood, mean(SE) beta 0.47(0.19), p=0.014 in males, 0.82(017) p<0.0001 in females. In males, high maternal BMI and low age at adiposity rebound and in females high birth weight were also associated with a statistically significant risk. Additionally, contraceptive use in females was a risk factor for elevated cardiometabolic score and, in males a high lifestyle related index score showed a protective association with the cardiometabolic score. Conclusion: A high BMI z-score at ten years of age is a risk factor for the cardiometabolic state in young adults, an outcome points to the preventive potential of monitoring BMI in ten-year-old schoolchildren. This finding must however be validated in a new large cohort. Moreover, in young adults in whom metabolic syndrome is rare, a cardiometabolic score seems to be a promising approach and potentially a more powerful tool to detect risks for cardiovascular disease later in life, than using metabolic syndrome categorisation.

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Effects of a Healthy Lifestyle Education on the Incidence of Metabolic Syndrome in Children during a 13-Year Follow-up

Abstract: This study was funded by National Research Council and Planning and Management Organization and has been reviewed and approved by the Iranian registry of clinical trials (ISRCTN52588395).

Cited by 3 publications

References 31 publications

Circulating serum vitamin D levels in relation to metabolic syndrome in children: A systematic review and dose–response meta‐analysis of epidemiologic studies

Circulating serum vitamin D levels in relation to metabolic syndrome in children: A systematic review and dose–response meta‐analysis of epidemiologic studies

Prevention of Obesity and Metabolic Syndrome in Children

Features of Childhood Growth, Lifestyle, and Environment Associated with a Cardiometabolic Risk Score in Young Adults

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