Effects of a food supplement rich in arginine in patients with smear positive pulmonary tuberculosis – A randomised trial

Schӧn, Thomas; Idh, Jonna; Westman, Anna; Eliáš, Daniel; Abate, Ebba; Diro, Ermias; Moges, Feleke; Kassu, Afework; Ayele, Belete Achamyelew; Forslund, Tony; Assefa, Getachew; Britton, Sven; Stendahl, Olle; Sundqvist, Tommy

doi:10.1016/j.tube.2011.06.002

Cited by 38 publications

(35 citation statements)

References 25 publications

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“…Macrophages in the lungs of humans (6,7) and macaques (8) with TB express functional iNOS. Correlative evidence suggests that the action of iNOS may contribute to human control of TB (1,3,9,10).…”

mentioning

confidence: 99%

Nitrite produced byMycobacterium tuberculosisin human macrophages in physiologic oxygen impacts bacterial ATP consumption and gene expression

Cunningham‐Bussel¹,

Zhang

Nathan³

2013

Proc. Natl. Acad. Sci. U.S.A.

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In high enough concentrations, such as produced by inducible nitric oxide synthase (iNOS), reactive nitrogen species (RNS) can kill Mycobacterium tuberculosis (Mtb). Lesional macrophages in macaques and humans with tuberculosis express iNOS, and mice need iNOS to avoid succumbing rapidly to tuberculosis. However, Mtb's own ability to produce RNS is rarely considered, perhaps because nitrate reduction to nitrite is only prominent in axenic Mtb cultures at oxygen tensions ≤1%. Here we found that cultures of Mtbinfected human macrophages cultured at physiologic oxygen tensions produced copious nitrite. Surprisingly, the nitrite arose from the Mtb, not the macrophages. Mtb responded to nitrite by ceasing growth; elevating levels of ATP through reduced consumption; and altering the expression of 120 genes associated with adaptation to acid, hypoxia, nitric oxide, oxidative stress, and iron deprivation. The transcriptomic effect of endogenous nitrite was distinct from that of nitric oxide. Thus, whether or not Mtb is hypoxic, the host expresses iNOS, or hypoxia impairs the action of iNOS, Mtb in vivo is likely to encounter RNS by producing nitrite. Endogenous nitrite may slow Mtb's growth and prepare it to resist host stresses while the pathogen waits for immunopathology to promote its transmission.

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mentioning

confidence: 99%

Nitrite produced byMycobacterium tuberculosisin human macrophages in physiologic oxygen impacts bacterial ATP consumption and gene expression

Cunningham‐Bussel¹,

Zhang

Nathan³

2013

Proc. Natl. Acad. Sci. U.S.A.

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show abstract

“…1,15 In addition to early initiation of ART, counselling for effective adherence and nutritional support would improve the CD4 counts and prevent the high mortality rate among co-infected patients. 9,16,19 Both positive and negative anti-tuberculosis treatment outcomes were statistically the same before and after the intervention in the two districts. Some of the reasons highlighted for this included the lack of sufficient food for the patients, a lack of permanent trained staff in the service in some HFs, lack of staff motivation and fear of being infected by TB.…”

Section: Public Health Action One-stop Tb-hiv Services In Rwanda 212mentioning

confidence: 86%

One-stop TB-HIV services evaluation in Rwanda: comparison of the 2001–2005 and 2006–2010 cohorts

Ndagijimana

Rugigana

Uwizeye

et al. 2015

public health action

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“…Despite the wide research on the applications of arginine in food [21,22] and pharmaceuticals industries [23], the compaction properties of this amino acid were never investigated. Prior to evaluating the compaction behaviour of ARG, the micromeritic characteristics; particle size, are shown in Fig.…”

Section: Powder Characterisationmentioning

confidence: 99%

A methodological evaluation and predictive in silico investigation into the multi-functionality of arginine in directly compressed tablets

ElShaer

Kaialy

Akhtar

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

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Effects of a food supplement rich in arginine in patients with smear positive pulmonary tuberculosis – A randomised trial

Cited by 38 publications

References 25 publications

Nitrite produced byMycobacterium tuberculosisin human macrophages in physiologic oxygen impacts bacterial ATP consumption and gene expression

Nitrite produced byMycobacterium tuberculosisin human macrophages in physiologic oxygen impacts bacterial ATP consumption and gene expression

One-stop TB-HIV services evaluation in Rwanda: comparison of the 2001–2005 and 2006–2010 cohorts

A methodological evaluation and predictive in silico investigation into the multi-functionality of arginine in directly compressed tablets

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