Effects of a five-day HD-tDCS application to the right IFG depend on current intensity: A study in children and adolescents with ADHD

Breitling-Ziegler, Carolin; Zaehle, Tino; Wellnhofer, Christian; Dannhauer, Moritz; Tegelbeckers, Jana; Baumann, Valentin; Flechtner, Hans‐Henning; Krauel, Kerstin

doi:10.1016/bs.pbr.2021.01.014

Cited by 14 publications

(44 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of the nine RCTs, overall risk-of-bias was rated as “high” in five studies [32,33,36,52,56]; two with “some concerns” [37,39], and two with “low” [29,38] (see Supplementary Material S2). The non-randomised, controlled clinical trial was rated with moderate risk of bias [54].…”

Section: Resultsmentioning

confidence: 99%

“…five in ADHD [35][36][37][38][39], four in schizophrenia [40][41][42][43], two each in OCD [44,45], Tourette's syndrome [46,47], depression [48,49], anxiety [50,51], or substance abuse disorder [52,53], and one each in eating disorders [54], catatonia [55], or co-comorbid ASD, ADHD and anxiety [56]. Across studies, tDCS was typically delivered for 20 to 30-mins (M=23; SD = 4.43) once-daily over 4 to 28 sessions (M=12; SD = 7.07).…”

Section: Resultsmentioning

confidence: 99%

“…Overall, these inconsistent or unexpected findings (i.e. [31,37,46,47]) underline the need to improve understand the underlying biophysiological mechanisms of tDCS, as well as how different parameters (e.g. stimulation intensity) interact with the tissue being stimulated.…”

Section: Discussionmentioning

confidence: 99%

“…This is of concern given the neurophysiological effects of tDCS may be non-linear, and because emerging evidence suggests tDCS may modulate cortical excitability via the scalp and/or peripheral nerves, which may complicate predictions about the dose-response relationship and the reproducibility of findings [71]. For example, in one RCT [37], adolescents with ADHD received sham (n=13), or 0.5mA (n=9), or 0.25mA (n=11) anodal HD-tDCS to the IFC depending on cutaneous sensitivity. Compared to sham, the 0.25mA group showed significantly reduced response inhibition, an effect not observed in the 0.5mA group, which opposed the authors hypothesis that increasing right-IFC activity would improve executive function.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of Transcranial Direct Current Stimulation in Children and Young People with Psychiatric Disorders: A Systematic Review

Gallop

Westwood

Lewis

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Transcranial direct current stimulation (tDCS) has demonstrated benefits in adults with various psychiatric disorders, but its clinical utility in children and young people (CYP) remains unclear. Objective: This PRISMA systematic review used published and ongoing studies to examine the effects of tDCS on disorder-specific symptoms, mood and neurocognition in CYP with psychiatric disorders. Methods: We searched Medline via PubMed, Embase, PsychINFO via OVID, and Clinicaltrials.gov up to January 2022. Eligible studies involved multiple session (i.e. treatment) tDCS in CYP (≤ 25 years-old) with psychiatric disorders. Two independent raters assessed the eligibility of studies and extracted data using a custom-built form. Results: Of 28 eligible studies (participant N= 379), the majority (n = 23) reported an improvement in at least one outcome measure of disorder-specific symptoms. Few studies (n = 9) examined tDCS effects on mood and/or neurocognition, but findings were mainly positive. Overall, tDCS was well-tolerated with minimal side-effects. Of 11 eligible ongoing studies, many are sham-controlled RCTs (n = 9) with better blinding techniques and a larger estimated participant enrolment (M = 74.7; range: 11-172) than published studies. Conclusions: Findings provide encouraging evidence of tDCS-related improvement in disorder-specific symptoms, but evidence remains limited, especially in terms of mood and neurocognitive outcomes. Ongoing studies appear to be of improved methodological quality; however, future studies should broaden outcome measures to more comprehensively assess the effects of tDCS and develop dosage guidance (i.e. treatment regimens).

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Transcranial Direct Current Stimulation in Children and Young People with Psychiatric Disorders: A Systematic Review

Gallop

Westwood

Lewis

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Sedgmond J et al found that no evidence that HD-tDCS with a 1.5 mA current in the prefrontal influences cue-induced food craving [89]. Breitling-Ziegler C et al found that distinct effects of tDCS with different current intensities demonstrating the importance of a deeper understanding on the impact of stimulation parameters and repeated tDCS applications to develop effective tDCS-based therapy approaches [90]. Low stimulation intensity might be a possible reason for the lack of effects seen.…”

Section: The Impact Of Tdcs On Rehomentioning

confidence: 99%

Repeated anodal high-definition transcranial direct current stimulation over the left dorsolateral prefrontal cortex in mild cognitive impairment patients increased regional homogeneity in multiple brain regions

et al. 2021

PLoS ONE

View full text Add to dashboard Cite

Transcranial direct current stimulation (tDCS) can improve cognitive function. However, it is not clear how high-definition tDCS (HD-tDCS) regulates the cognitive function and its neural mechanism, especially in individuals with mild cognitive impairment (MCI). This study aimed to examine whether HD-tDCS can modulate cognitive function in individuals with MCI and to determine whether the potential variety is related to spontaneous brain activity changes recorded by resting-state functional magnetic resonance imaging (rs-fMRI). Forty-three individuals with MCI were randomly assigned to receive either 10 HD-tDCS sessions or 10 sham sessions to the left dorsolateral prefrontal cortex (L-DLPFC). The fractional amplitude of low-frequency fluctuation (fALFF) and the regional homogeneity (ReHo) was computed using rs-fMRI data from all participants. The results showed that the fALFF and ReHo values changed in multiple areas following HD-tDCS. Brain regions with significant decreases in fALFF values include the Insula R, Precuneus R, Thalamus L, and Parietal Sup R, while the Temporal Inf R, Fusiform L, Occipital Sup L, Calcarine R, and Angular R showed significantly increased in their fALFF values. The brain regions with significant increases in ReHo values include the Temporal Inf R, Putamen L, Frontal Mid L, Precentral R, Frontal Sup Medial L, Frontal Sup R, and Precentral L. We found that HD-tDCS can alter the intensity and synchrony of brain activity, and our results indicate that fALFF and ReHo analysis are sensitive indicators for the detection of HD-tDCS during spontaneous brain activity. Interestingly, HD-tDCS increases the ReHo values of multiple brain regions, which may be related to the underlying mechanism of its clinical effects, these may also be related to a potential compensation mechanism involving the mobilization of more regions to complete a function following a functional decline.

show abstract

A systematic review of randomized controlled trials on efficacy and safety of transcranial direct current stimulation in major neurodevelopmental disorders: ADHD, autism, and dyslexia

et al. 2022

View full text Add to dashboard Cite

Objective: Among the target groups in child and adolescent psychiatry, transcranial direct current stimulation (tDCS) has been more applied in neurodevelopmental disorders specifically, attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and dyslexia. This systematic review aims to provide the latest update on published randomized-controlled trials applying tDCS in these disorders for evaluating its efficacy and safety.Methods: Based on a pre-registered protocol (PROSPERO: CRD42022321430) and using the PRISMA approach, a literature search identified 35 randomized controlled trials investigating the effects of tDCS on children and adolescents with ADHD (n = 17), ASD (n = 11), and dyslexia (n = 7). Results:In ADHD, prefrontal anodal tDCS is reported more effective compared to stimulation of the right inferior frontal gyrus. Similarly in ASD, prefrontal anodal tDCS was found effective for improving behavioral problems. In dyslexia, stimulating temporoparietal regions was the most common and effective protocol. In ASD and dyslexia, all tDCS studies found an improvement in at least one of the outcome variables while 64.7% of studies (11 of 17) in ADHD found a similar effect. About 88% of all tDCS studies with a multi-session design in 3 disorders (16 of 18) reported a significant improvement in one or all outcome variables after the intervention. Randomized, double-blind, controlled trials consisted of around 70.5%, 36.3%, and 57.1% of tDCS studies in ADHD, ASD, and dyslexia, respectively. tDCS was found safe with no reported serious side effects in 6587 sessions conducted on 745 children and adolescents across 35 studies. Conclusion: tDCS was found safe and partially effective. For evaluation of clinical utility, larger randomized controlled trials with a double-blind design and follow-up measurements are required. Titration studies that systematically evaluate different stimulation intensities, duration, and electrode placement are lacking.

show abstract

Effects of a five-day HD-tDCS application to the right IFG depend on current intensity: A study in children and adolescents with ADHD

Cited by 14 publications

References 94 publications

Effects of Transcranial Direct Current Stimulation in Children and Young People with Psychiatric Disorders: A Systematic Review

Effects of Transcranial Direct Current Stimulation in Children and Young People with Psychiatric Disorders: A Systematic Review

Repeated anodal high-definition transcranial direct current stimulation over the left dorsolateral prefrontal cortex in mild cognitive impairment patients increased regional homogeneity in multiple brain regions

A systematic review of randomized controlled trials on efficacy and safety of transcranial direct current stimulation in major neurodevelopmental disorders: ADHD, autism, and dyslexia

Contact Info

Product

Resources

About